Defining trained immunity and its role in health and disease

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

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The future of immune checkpoint therapy

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

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Innate or adaptive immunity? The example of natural killer cells

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Trained immunity: A program of innate immune memory in health and– disease

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NK CELL RECOGNITION

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The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting

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mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

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How neuroinflammation contributes to neurodegeneration

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

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Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

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Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

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Trained Immunity: A Memory for Innate Host Defense

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Adaptive Immune Features of Natural Killer Cells

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Innate immune recognition: mechanisms and pathways

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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

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Getting the measure of biodiversity

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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

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Gene-specific control of inflammation by TLR-induced chromatin modifications

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Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

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α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

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An epigenetic mutation responsible for natural variation in floral symmetry

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Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit

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Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors

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BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

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BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

Arts, R. J. W., Moorlag, S. J. C. F. M., Novakovic, B., Li, Y., Wang, S.-Y., Oosting, M., Kumar, V., Xavier, R. J., Wijmenga, C., Joosten, L. A. B., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2017.12.010 · Cited by 1,190 · see citing works

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

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Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Mitroulis, I., Ruppova, K., Wang, B., Chen, L.-S., Grzybek, M., Grinenko, T., Eugster, A., Troullinaki, M., Palladini, A., Kourtzelis, I., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.034 · Cited by 1,100 · see citing works

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Christ, A., Günther, P. S., Lauterbach, M. A. R., Duewell, P., Biswas, D., Pelka, K., Scholz, C. J., Oosting, M., Händler, K., Bassler, K. E., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.013 · Cited by 1,099 · see citing works

The Principles of Engineering Immune Cells to Treat Cancer

Lim, W. A., & June, C. H. (2017) · Cell · doi:10.1016/j.cell.2017.01.016 · Cited by 1,084 · see citing works

Priming for Enhanced Defense

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The role of IL-6 and STAT3 in inflammation and cancer.

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Innate immune memory in the brain shapes neurological disease hallmarks

Wendeln, A.-C., Degenhardt, K., Kaurani, L., Gertig, M., Ulas, T., Jain, G., Wagner, J., Häsler, L. M., Wild, K., Skodras, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0023-4 · Cited by 956 · see citing works

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

Patel, A. A., Zhang, Y., Fullerton, J. N., Boelen, L., Rongvaux, A., Maini, A. A., Bigley, V., Flavell, R. A., Gilroy, D. W., Asquith, B., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20170355 · Cited by 946 · see citing works

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

Romee, R., Rosario, M., Berrien-Elliott, M. M., Wagner, J. A., Jewell, B. A., Schappe, T., Leong, J. W., Abdel-Latif, S., Schneider, S. E., Willey, S., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2341 · Cited by 944 · see citing works

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Arts, R. J. W., Novakovic, B., ter Horst, R., Carvalho, A., Bekkering, S., Lachmandas, E., Rodrigues, F., Silvestre, R., Cheng, S.-C., Wang, S.-Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.008 · Cited by 930 · see citing works

The Evolution of Adaptive Immune Systems

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Adaptive immunity

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Cytokine-induced memory-like natural killer cells

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Inositol phosphatase SHIP1 is a primary target of miR-155

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Metabolic Induction of Trained Immunity through the Mevalonate Pathway

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Herpesvirus latency confers symbiotic protection from bacterial infection

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Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

Meyers, P. A., Schwartz, C. L., Krailo, M. D., Healey, J. H., Bernstein, M. L., Betcher, D., Ferguson, W. S., Gebhardt, M. C., Goorin, A. M., Harris, M., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.14.0095 · Cited by 752 · see citing works

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage

Naik, S., Larsen, S. B., Gomez, N. C., Alaverdyan, K., Sendoel, A., Yuan, S., Polak, L., Kulukian, A., Chai, S., & Fuchs, E. (2017) · Nature · doi:10.1038/nature24271 · Cited by 745 · see citing works

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

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The mechanism of action of BCG therapy for bladder cancer--a current perspective

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ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

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CONTRIBUTION TO THE KNOWLEDGE OF SARCOMA

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Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

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NK cell development, homeostasis and function: parallels with CD8+ T cells

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Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses

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β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

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Cytokine activation induces human memory-like NK cells

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Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans

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Immunometabolic Pathways in BCG-Induced Trained Immunity

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Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages

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Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection

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Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens

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Allergic inflammatory memory in human respiratory epithelial progenitor cells

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Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?

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T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

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The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

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Effect of Bacillus Calmette-Guérin Infection on Transplanted Tumours in the Mouse

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Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

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The gut microbiota influences anticancer immunosurveillance and general health

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ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

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Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

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A small jab – a big effect: nonspecific immunomodulation by vaccines

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Acute Infection and Myocardial Infarction

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BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

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Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus

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Therapeutic targeting of trained immunity

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Inflammation and cerebral small vessel disease: A systematic review

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Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

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Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche

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Specific memory within innate immune systems

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The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

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Human Cytomegalovirus (CMV)-Induced Memory-like NKG2C+ NK Cells Are Transplantable and Expand In Vivo in Response to Recipient CMV Antigen

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Non-specific beneficial effect of measles immunisation: analysis of mortality studies from developing countries

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Susquehanna Chorale Spring Concert "Roots and Wings"

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