Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats
Open accessAbstract
BACKGROUND: Glucocorticoid is among the most commonly prescribed medicine. Unfortunately, Excess glucocorticoid level leads hypertension in 80-90% patients. Garlic (Allium sativum) has been used since ancient times and even nowadays as a part of popular medicine for various ailments and physiological disorders. Hence this study was undertaken to investigate the antihypertensive activity of allicin in dexamethasone induced hypertension in wistar rats. METHODS: The animals were randomly divided into four groups comprising of six rats per group. Hypertension was induced by subcutaneous injection of dexamethasone (10 μg/rat/day) in hypertensive rats. Two hypertensive group animals were treated with nicorandil (6 mg/kg/day, po) and allicin (8 mg/kg/day, po) respectively for 8 weeks. While systolic blood pressure (SBP) was measured by the tail-cuff method weekly up to 8 weeks. RESULTS: Dexamethasone treatment resulted in significant increase in SBP while allicin treatment significantly decreases the SBP. Thus, this study confirmed that allicin treatment for 8 weeks partially reverse dexamethasone induced hypertension in rats. Allicin treatment also attenuated dexamethasone-induced anorexia and loss of total body weight. CONCLUSION: This result suggests antihypertensive effects of allicin in dexamethasone induced hypertension. However, further studies are needed to explore the detailed mechanism of antihypertensive effect of allicin.
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Aqueous garlic extract has an antihypertensive effect in the '2 kidney 1-clip' model of hypertension in rat by reducing thromboxane B2 and prostaglandin E2 level.
“in vivo experiment exhibited the antihypertensive effect of aqueous garlic extract in ‘2 kidney 1-clip’ model of hypertension in rat by reducing thromboxane B2 and prostaglandin E2 level and thereby reduced hypertension in tested rats [122].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [122]
Allicin shows remarkable activity in reversing systolic blood pressure caused by dexamethasone and enhances body weight and food intake in hypertension caused by dexamethasone in rats.
“Dubey et al. [122] revealed that allicin shows remarkable activity in reversing systolic blood pressure caused by dexamethasone and enhances body weight and food intake in hypertension caused by dexamethasone in rats.”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [122]
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VARDİYA USULÜ ÇALIŞMANIN HEMŞİRELERİN SOSYAL YAŞAMI VE EV YAŞAMI ÜZERİNDEKİ ETKİLERİNİN İNCELENMESİ
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Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931 · see citing works
- Authors
- Dubey, H., Singh, A., Patole, A. M., & Tenpe, C. R.
- Affiliations
- University of Delhi (IN)
- Corresponding author
- Dubey, Harikesh
- Venue
- Integrative Medicine Research
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 6
- Issue
- 1
- Pages
- 60-65
- ISSN
- 2213-4220 (ISSN-L)
- PMC
- PMC5395682
- OpenAlex
- W2562800027
- Cited by
- 47
- References
- 43
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 3 · 2023: 10 · 2022: 9 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 1
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Integrative Medicine Research (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- allicin, glucocorticoid-induced hypertension, antihypertensive effect, garlic, nicorandil, systolic blood pressure, anorexia, weight loss
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