The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines
Open accessAbstract
The leaves of Myrica rubra (Sieb. et Zucc), a subtropical Asian fruit tree with traditional use in folk medicines, were extracted by hydrodistillation. The antiproliferative effect of obtained M. rubra essential oil (MEO) was tested in human colon and ileocecal adenocarcinoma cell lines HCT8, SW620, SW480, HT29 and Caco2. Cytostatic drug paclitaxel was used as a positive control. MEO significantly inhibited cell proliferation in concentration-dependant manner in all cell lines. The efficacy of MEO differed in individual cell lines, with Caco2 being the most sensitive. In these cells, MEO IC50 value of 1.5μg/mL was obtained using xCelligence system for real-time cell monitoring. In cancer cells, MEO induces apoptosis and caused significant increase of activities of initiator as well as effector caspases. Contrary to cancer cells, MEO did not affect viability of isolated hepatocytes (as a model of normal non-cancerous cells). GC×GC-TOFMS analysis of MEO chemical composition revealed β-caryophyllene, α-humulene, humulene epoxide I, valencene, epi-α-selinene, γ-muurolene, β-caryphyllene-oxide, and trans-nerolidol as dominant compounds.
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“This compound has shown anti-inflammatory and antitumor activity in lung, colon, prostate, and breast cancer.”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [44]
In the citing paper
“Some studies reported that α-humulene demonstrated antiproliferative activity and alteration of the mitochondrial cell membrane in colon cancer cells [14,37,42,43,44,45,46].”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [44]
In the citing paper
“It can also improve the antiproliferative effect of cytostatic drugs and other anticancer bioactivities [42,44].”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [44]
Citations
Cites
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Anticancer activity of an essential oil from Cymbopogon flexuosus
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Biological Activities of Extracts from Chinese Bayberry (Myrica rubra Sieb. et Zucc.): A Review
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Triterpenoids from Myrica rubra
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- Keawsa-ard, 2012, Antioxidant, antibacterial, anticancer activities and chemical constituents of the essential oil from Mesua ferrea leaves, Chiang Mai J. Sci., 39, 455
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Haro-González, J. N., Castillo-Herrera, G. A., Martínez-Velázquez, M., & Espinosa-Andrews, H. (2021) · Molecules · doi:10.3390/molecules26216387 · Cited by 463
Ambrož, M., Šmatová, M., Šadibolová, M., Pospíšilová, E., Hadravská, P., Kašparová, M., Skarková, V. H., Králová, V., & Skálová, L. (2019) · Acta Pharmaceutica · doi:10.2478/acph-2019-0003 · Cited by 52
Aranha, E. S. P., de Azevedo, S. G., dos Reis, G. G., Silva Lima, E., Machado, M. B., & de Vasconcellos, M. C. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.111736 · Cited by 17
Metadata
- Authors
- Langhasova, L., Hanusova, V., Rezek, J., Stohanslova, B., Ambroz, M., Kralova, V., Vanek, T., Lou, J. D., Yun, Z. L., Yang, J., & Skalova, L.
- Affiliations
- Czech Academy of Sciences (CZ)
- China Jiliang University (CN)
- China Tobacco (CN)
- ORCID
- Venue
- Industrial Crops and Products
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 59
- Pages
- 20-26
- ISSN
- 0926-6690 (ISSN-L)
- OpenAlex
- W2086836946
- Cited by
- 46
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 2
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Industrial Crops and Products (publishedVersion)
- ASEP (submittedVersion, public-domain)
- Funders
- Ministry of Education Youth, and Sports of the Czech Republic
- Prague
- Czech Science Foundation with the project Center of Excellence
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- Myrica rubra, essential oils, leaf essential oil, colon cancer, antiproliferative activity, apoptosis, caspase activation, Caco-2 cells, β-caryophyllene, essential oil composition, hepatotoxicity, anticancer natural products
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