The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Angiogenesis in bone regeneration
Open accessAbstract
Angiogenesis is a key component of bone repair. New blood vessels bring oxygen and nutrients to the highly metabolically active regenerating callus and serve as a route for inflammatory cells and cartilage and bone precursor cells to reach the injury site. Angiogenesis is regulated by a variety of growth factors, notably vascular endothelial growth factor (VEGF), which are produced by inflammatory cells and stromal cells to induce blood vessel in-growth. A variety of studies with transgenic and gene-targeted mice have demonstrated the importance of angiogenesis in fracture healing, and have provided insights into regulatory processes governing fracture angiogenesis. Indeed, in animal models enhancing angiogenesis promotes bone regeneration, suggesting that modifying fracture vascularization could be a viable therapeutic approach for accelerated/improved bone regeneration clinically.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mesenchymal stem cells as trophic mediators
Caplan, A. I., & Dennis, J. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20886 · Cited by 2,992
Gerber, H.-P., Vu, T. H., Ryan, A. M., Kowalski, J., Werb, Z., & Ferrara, N. (1999) · Nature Medicine · doi:10.1038/9467 · Cited by 2,085
Asahara, T., Takahashi, T., Masuda, H., Kalka, C., Chen, D., Iwaguro, H., Inai, Y., Silver, M., & Isner, J. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3964 · Cited by 1,856
Street, J., Bao, M., deGuzman, L., Bunting, S., Peale, F. V., Ferrara, N., Steinmetz, H., Hoeffel, J., Cleland, J. L., Daugherty, A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152324099 · Cited by 1,404
Molecular and biological properties of vascular endothelial growth factor
Ferrara, N. (1999) · Journal of Molecular Medicine · doi:10.1007/s001099900019 · Cited by 1,158
Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein
Goldberg, M. A., Dunning, S. P., & Bunn, H. F. (1988) · Science · doi:10.1126/science.2849206 · Cited by 1,031
Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound.
Heckman, J. D., Ryaby, J. P., McCabe, J., Frey, J. J., & Kilcoyne, R. F. (1994) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199401000-00004 · Cited by 956
Basic fibroblast growth factor induces angiogenesis in vitro.
Montesano, R., Vassalli, J. D., Baird, A., Guillemin, R., & Orci, L. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.19.7297 · Cited by 844
Wang, Y., Wan, C., Deng, L., Liu, X., Cao, X., Gilbert, S. R., Bouxsein, M. L., Faugere, M.-C., Guldberg, R. E., Gerstenfeld, L. C., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31581 · Cited by 733
Effects of Mechanical Factors on the Fracture Healing Process
Claes, L. E., Heigele, C. A., Neidlinger-Wilke, C., Kaspar, D., Seidl, W., Margevicius, K. J., & Augat, P. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00015 · Cited by 705
Cited by
It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration
Grosso, A., Burger, M. G., Lunger, A., Schaefer, D. J., Banfi, A., & Di Maggio, N. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00068 · Cited by 445
Current Status of the Diagnosis and Management of Osteoporosis
Aibar-Almazán, A., Voltes-Martínez, A., Castellote-Caballero, Y., Afanador-Restrepo, D. F., Carcelén-Fraile, M. D. C., & López-Ruiz, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169465 · Cited by 412
Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration
Diomede, F., Marconi, G. D., Fonticoli, L., Pizzicanella, J., Merciaro, I., Bramanti, P., Mazzon, E., & Trubiani, O. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093242 · Cited by 401
Extracellular matrix-inspired growth factor delivery systems for bone regeneration
Martino, M. M., Briquez, P. S., Maruyama, K., & Hubbell, J. A. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.04.007 · Cited by 261
The Metabolic Microenvironment Steers Bone Tissue Regeneration
Loeffler, J., Duda, G. N., Sass, F. A., & Dienelt, A. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.11.008 · Cited by 113
Metadata
- Authors
- Hankenson, K. D., Dishowitz, M., Gray, C., & Schenker, M.
- Venue
- Injury
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 42
- Issue
- 6
- Pages
- 556-561
- ISSN
- 0020-1383 (ISSN-L)
- OpenAlex
- W2025422403
- Cited by
- 560
- References
- 72
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Angiogenesis in bone regeneration. https://app.cochat.ai/papers/10.1016/j.injury.2011.03.035
- The paper
- Hankenson, K. D., Dishowitz, M., Gray, C., & Schenker, M. (2011). Angiogenesis in bone regeneration. Injury. https://doi.org/10.1016/j.injury.2011.03.035
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
