The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration
Open accessAbstract
Bone tissue renewal can be outlined as a complicated mechanism centered on the interaction between osteogenic and angiogenic events capable of leading to bone formation and tissue renovation. The achievement or debacle of bone regeneration is focused on the primary role of vascularization occurrence; in particular, the turning point is the opportunity to vascularize the bulk scaffolds, in order to deliver enough nutrients, growth factors, minerals and oxygen for tissue restoration. The optimal scaffolds should ensure the development of vascular networks to warrant a positive suitable microenvironment for tissue engineering and renewal. Vascular Endothelial Growth Factor (VEGF), a main player in angiogenesis, is capable of provoking the migration and proliferation of endothelial cells and indirectly stimulating osteogenesis, through the regulation of the osteogenic growth factors released and through paracrine signaling. For this reason, we concentrated our attention on two principal groups involved in the renewal of bone tissue defects: the cells and the scaffold that should guarantee an effective vascularization process. The application of Mesenchymal Stem Cells (MSCs), an excellent cell source for tissue restoration, evidences a crucial role in tissue engineering and bone development strategies. This review aims to provide an overview of the intimate connection between blood vessels and bone formation that appear during bone regeneration when MSCs, their secretome—Extracellular Vesicles (EVs) and microRNAs (miRNAs) —and bone substitutes are used in combination.
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Cites
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Investigation of multipotent postnatal stem cells from human periodontal ligament
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Stem cells: past, present, and future
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“Therefore, endothelial cells, angiogenic cytokines, such as Fibroblast Growth Factor (FGF), VEGF, Transforming Growth Factor-Beta (TGF-β) and mast cell tryptase cooperate in a dynamic communication in order to promote new blood vessel formation and injury repair [44].”
BackgroundConnecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
Marson, A., Levine, S. S., Cole, M. F., Frampton, G. M., Brambrink, T., Johnstone, S., Guenther, M. G., Johnston, W. K., Wernig, M., Newman, J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.020 · Cited by 1,370
The Role of Vascular Endothelial Growth Factor in Wound Healing
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Role of microRNAs in vascular diseases, inflammation, and angiogenesis
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Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2
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Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix
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Cited by
Xue, H., Zhang, Z., Lin, Z., Su, J., Panayi, A. C., Xiong, Y., Hu, L., Hu, Y., Chen, L., Yan, C., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.023 · Cited by 65
Santinoni, C. S., Neves, A. P. C., Almeida, B. F. M., Kajimoto, N. C., Pola, N. M., Caliente, E. A., Belem, E. L. G., Lelis, J. B., Fucini, S. E., Messora, M. R., et al. (2021) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37076 · Cited by 32
Gerami, M. H., Khorram, R., Rasoolzadegan, S., Mardpour, S., Nakhaei, P., Hashemi, S., Al-Naqeeb, B. Z. T., Aminian, A., & Samimi, S. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01034-5 · Cited by 27
RetractedThe Therapeutic Potential of Hematopoietic Stem Cells in Bone Regeneration
Oliveira, C. S., Carreira, M., Correia, C. R., & Mano, J. F. (2022) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2021.0019 · Cited by 14
Zhang, J.-S., Wang, Z.-B., Lai, Z.-Z., Yang, J.-W., Song, W.-J., Wei, Y.-B., Mei, J., & Wang, J.-G. (2023) · Hepatobiliary & Pancreatic Diseases International · doi:10.1016/j.hbpd.2022.10.007 · Cited by 11
Metadata
- Authors
- Diomede, F., Marconi, G. D., Fonticoli, L., Pizzicanella, J., Merciaro, I., Bramanti, P., Mazzon, E., & Trubiani, O.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-05-03
- Volume
- 21
- Issue
- 9
- Pages
- 3242
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3022100157
- Cited by
- 401
- References
- 66
- FWCI
- 15.56
- Type
- journal article
- Language
- en
- Open access
- gold
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- Diomede, F., Marconi, G. D., Fonticoli, L., Pizzicanella, J., Merciaro, I., Bramanti, P., Mazzon, E., & Trubiani, O. (2020). Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21093242
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
