A polysaccharide from Strongylocentrotus nudus eggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated mice
Abstract
To assess the chemoprotective properties of a polysaccharide from Strongylocentrotus nudus eggs (SEP), myelosuppressed and immunosuppressed mouse models were generated by administration of cyclophosphamide (Cy) and then treated with SEP. SEP (16 mg/kg/d) remarkably increased spleen and thymus indices, activated the proliferation of leukocytes and erythrocytes and platelets from peripheral blood, and exhibited co-mitogenic activity on ConA- or LPS-stimulated splenocytes in a dose-dependent manner. An increased percentage of CD34(+) cells in bone marrow of Cy-treated mice was also observed. Furthermore, SEP elevated CD4(+) T lymphocyte counts as well as the CD4/CD8 ratio dose-dependently, and it increased interleukin-2 (IL-2), IgA, IgM, and IgG levels in the sera of Cy-treated mice. Pre-incubation with TLR2 and TLR4 blocking antibodies inhibited splenocyte proliferation and its IL-2 secretion. Finally, SEP significantly induced Akt phosphorylation in splenocytes from Cy-treated mice, suggesting that chemoprotection by SEP was mediated through the PI3K/Akt signaling pathway. These findings indicate that SEP plays an important role in the protection against myelosuppression and immunosuppression in Cy-treated mice and could be a potential immunomodulatory agent.
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Polysaccharide SEP isolated from the eggs of the sea urchin Strongylocentrotus nudus effectively inhibited the growth of S180 tumor and hepatocellular carcinoma in vivo via activation of lymphocytes and macrophages, amplification of B and T cell proliferation, and increased secretion of IL-2, TNF-α and IFN-γ.
“Polysaccharide SEP isolated from the eggs of the sea urchin Strongylocentrotus nudus effectively inhibited the growth of S180 tumor and the hepatocellular carcinoma in vivo via the activation of lymphocytes and macrophages, amplification of B and T cell proliferation, and increased secretion of such cytokines as IL-2, TNF-α and IFN-γ [138,139,140,141].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [141]
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References 41 · Cited by 146
- Authors
- Wang, H., Wang, M., Chen, J., Tang, Y., Dou, J., Yu, J., Xi, T., & Zhou, C.
- Affiliations
- China Pharmaceutical University (CN)
- Corresponding author
- Xi, Tao
- Zhou, Changlin
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 11
- Issue
- 11
- Pages
- 1946-1953
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W2055533912
- Cited by
- 146
- References
- 41
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 13 · 2021: 8 · 2020: 14 · 2019: 13 · 2018: 14 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 11 · 2013: 8 · 2012: 5
- FWCI
- 12.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Major Science and Technology Projects of China (2009ZX09103-655)
- Ministry of Education of the People's Republic of China
- Government of Jiangsu Province
- State Administration of Foreign Experts Affairs (111-2-07)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- polysaccharides, chemoprotection, myelosuppression, immunosuppression, cyclophosphamide, immunomodulation, TLR2, TLR4, PI3K/Akt signaling, CD4/CD8 ratio, interleukin-2, splenocyte proliferation, CD34+ hematopoietic progenitor cells, sea urchins
- MeSH terms
- Animals, Bone Marrow, Cells, Cultured, Cyclophosphamide, Dose-Response Relationship, Immunologic, Immune Tolerance, Immunoglobulins, Interleukin-2, Macrophages, Male, Mice, Inbred BALB C, Ovum, Phagocytosis, Polysaccharides, Spleen, Thymus Gland, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Strongylocentrotus, Cell Proliferation, Mice
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