Research progress on the anti-hepatic fibrosis action and mechanism of natural products

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963

The global burden of liver disease: The major impact of China

Wang, F., Fan, J., Zhang, Z., Gao, B., & Wang, H. (2014) · Hepatology · doi:10.1002/hep.27406 · Cited by 1,262

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

Bertola, A., Mathews, S., Ki, S. H., Wang, H., & Gao, B. (2013) · Nature Protocols · doi:10.1038/nprot.2013.032 · Cited by 1,239

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

Xu, F., Liu, C., Zhou, D., & Zhang, L. (2016) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155415627681 · Cited by 773

Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

Ramirez, T., Li, Y.-M., Yin, S., Xu, M.-J., Feng, D., Zhou, Z., Zang, M., Mukhopadhyay, P., Varga, Z. V., Pacher, P., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.11.004 · Cited by 186

Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling

Wang, R., Zhang, H., Wang, Y., Song, F., & Yuan, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.03.029 · Cited by 145

Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats

Pascoli, M. D., Diví, M., Rodrı́guez-Vilarrupla, A., Rosado, E., Gracia‐Sancho, J., Vilaseca, M., Bosch, J., & García‐Pagán, J. C. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.12.012 · Cited by 136

Animals Models of Gastrointestinal and Liver Diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges

Mathews, S., Xu, M., Wang, H., Bertola, A., & Gao, B. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00041.2014 · Cited by 127

Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/ mTOR /p70S6K and TGFβ/Smad signalling pathways

Li, J., Li, X., Xu, W., Wang, S., Hu, Z., Zhang, Q., Deng, X., Wang, J., Zhang, J., & Guo, C. (2014) · Liver International · doi:10.1111/liv.12638 · Cited by 125

Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion

Wu, Y., Liu, X., Zhou, Q. Y., Huang, C., Meng, X., Xu, F., & Li, J. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.09.028 · Cited by 117

Lycium barbarum polysaccharides improve CCl4-induced liver fibrosis, inflammatory response and TLRs/NF-kB signaling pathway expression in wistar rats

Gan, F., Liu, Q., Liu, Y., Huang, D. W., Pan, C., Song, S., & Huang, K. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.11.047 · Cited by 113

Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function

Li, R., Xu, L., Liang, T., Li, Y., Zhang, S., & Duan, X. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.10.059 · Cited by 111

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice

Wang, Y., Guan, M., Zhao, X., & Li, X. (2018) · Pharmaceutical Biology · doi:10.1080/13880209.2018.1479868 · Cited by 110

Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo

Yang, F., Luo, L., Zhu, Z., Zhou, X., Wang, Y., Xue, J., Zhang, J., Cai, X., Chen, Z.-L., Ma, Q., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00929 · Cited by 107

Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats

Yan, F., Zhang, Q., Jiao, L., Han, T., Zhang, H., Qin, L., & Khalid, R. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.02.004 · Cited by 106

Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation

Liu, Y., Wen, P., Zhang, X., Dai, Y., & He, Q. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3651 · Cited by 102

Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells

Wang, Q., Dai, X., Yang, W., Wang, H., Zhao, H., Yang, F., Yang, Y., Li, J., & Lv, X. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.02.012 · Cited by 95

Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells

Yu, H., Yao, Y., Bu, F., Chen, Y., Wu, Y., Yang, Y., Chen, X., Zhu, Y., Wang, Q., Pan, X., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.01.004 · Cited by 92

Hotair facilitates hepatic stellate cells activation and fibrogenesis in the liver

Bian, E., Wang, Y., Yang, Y., Wu, B., Xu, T., Meng, X., Huang, C. Z., Zhang, L., Lv, X., Xiong, Z., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.12.009 · Cited by 91

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways

Hernández‐Aquino, E., Zarco, N., Casas‐Grajales, S., Ramos‐Tovar, E., Flores‐Beltrán, R. E., Arauz, J., Shibayama, M., Favari, L., Tsutsumi, V., Segovia, J., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i24.4354 · Cited by 89

Effect of Fuzheng Huayu formula and its actions against liver fibrosis

Liu, C., Hu, Y., Xu, L., Liu, C., & Liu, P. (2009) · Chinese Medicine · doi:10.1186/1749-8546-4-12 · Cited by 82

Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis

Hsu, Y., Chiu, Y., Cheng, C., Wu, C., Lin, Y., & Huang, Y. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04361.x · Cited by 82

Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells

Wang, X., Ikejima, K., Kon, K., Arai, K., Aoyama, T., Okumura, K., Abe, W., Sato, N., & Watanabe, S. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.10.040 · Cited by 82

Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats

Lai, L., Chen, Y., Tian, X., Li, X., Zhang, X., Lei, J., Bi, Y., Fang, B., & Song, X. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.040 · Cited by 81

Activation of autophagy is required for Oroxylin A to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation

Chen, W., Zhang, Z., Yao, Z., Wang, L., Zhang, F., Shao, J., Chen, A., & Zheng, S. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.01.029 · Cited by 80

Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis

Wang, J., Li, L., Li, L., Qi, Y., Li, J., & Xu, T. (2018) · Gene · doi:10.1016/j.gene.2018.06.053 · Cited by 80

Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway

Baltă, C., Herman, H., Boldura, O. M., Gasca, I., Roșu, M., Ardelean, A., & Hermenean, A. O. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.08.013 · Cited by 79

Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway via Peroxisome Proliferator-Activated Receptor Gamma Activation

Choi, J. H., Jin, S. W., Choi, C. Y., Kim, H. G., Lee, G. H., Kim, Y.-A., Chung, Y., & Jeong, H. G. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04805 · Cited by 77

Novel Insights on Notch signaling pathways in liver fibrosis

Ni, M.-M., Wang, Y.-R., Wu, W., Xia, C.-C., Zhang, Y.-H., Xu, J., Xu, T., & Li, J. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.02.051 · Cited by 73

Smad2 protects against TGF-β1/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis

Zhang, L., Liu, C., Meng, X., Huang, C., Xu, F., & Li, J. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2258-1 · Cited by 73

Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats

Ezhilarasan, D., Karthikeyan, S., & Vivekanandan, P. (2012) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2012.07.004 · Cited by 70

Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells

Shu, J.-C., He, Y.-J., Lv, X., Ye, G.-R., & Wang, L. (2009) · Journal of Natural Medicines · doi:10.1007/s11418-009-0347-3 · Cited by 67

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

Guo, C., Li, J., Chen, K., Li, S., Feng, J., Liu, T., Wang, F., Zhang, R., Xu, S., Zhou, Y., et al. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s98740 · Cited by 66

Targeted blockade of JAK/STAT3 signaling inhibits proliferation, migration and collagen production as well as inducing the apoptosis of hepatic stellate cells

Gu, Y.-J., Sun, W., Zhang, S., Li, X., & Wei, W. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2692 · Cited by 66

Potent natural products and herbal medicines for treating liver fibrosis

Chen, S., Chen, X., Lu, J., Wang, Y., & Wang, Y. (2015) · Chinese Medicine · doi:10.1186/s13020-015-0036-y · Cited by 64

Oxymatrine attenuates CCl 4 -induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways

Zhao, H., Zhang, Z., Chai, X., Li, G.-Q., Cui, H., Wang, H., Meng, Y.-K., Liu, H., Wang, J., Li, R., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.04.040 · Cited by 62

Hypoxia-inducible factor-1alpha in hepatic fibrosis: A promising therapeutic target

Zhan, L., Huang, C., Meng, X., Song, Y., Wu, X. Q., Yang, Y., & Li, J. (2014) · Biochimie · doi:10.1016/j.biochi.2014.10.013 · Cited by 61

EZH2‐mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis

Yang, Y., Chen, X., Li, W., Wu, X., Huang, C., Xie, J., Zhao, Y., Meng, X., & Li, J. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13153 · Cited by 61

Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis

Chen, X., Li, W., Chen, Y., Li, X., Li, H.-D., Huang, H., Bu, F., Pan, X., Yang, Y., Huang, C., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1032-9 · Cited by 61

Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-β1/Smad signalling, MMPs and TIMPs

Peng, J., Li, X., Feng, Q., Chen, L., Xu, L., & Hu, Y. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213480741 · Cited by 60

Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis

Peng, X.-D., Dai, L., Huang, C.-Q., He, C., Yang, B., & Chen, L. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.099 · Cited by 58

Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model

Sang, L., Wang, X., Xu, D.-Y., Sang, L.-X., Han, Y., & Jiang, L. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i47.8334 · Cited by 55

Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis

Wang, H., Wu, G. J., Park, H. J., Jiang, P., Sit, W., van Griensven, L. J., & Wan, J. M. (2012) · Chinese Medicine · doi:10.1186/1749-8546-7-23 · Cited by 53

MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt/β-catenin pathway

Zhou, D., Wang, X., Wang, Y., Xiang, X.-J., Liang, Z.-C., Zhou, Y., Xu, A., Bi, C.-H., & Zhang, L. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.05.018 · Cited by 53

miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway

Yang, J., Tao, H., Liu, L., Hu, W. M., Deng, Z.-Y., & Li, J. (2016) · Inflammation Research · doi:10.1007/s00011-016-1020-4 · Cited by 52

Evodiamine ameliorates liver fibrosis in rats via TGF-β1/Smad signaling pathway

Yang, D., Li, L., Qian, S., & Liu, L. (2017) · Journal of Natural Medicines · doi:10.1007/s11418-017-1122-5 · Cited by 51

Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats

Yuan, L., Chen, F., Lü, L., Hu, B., Chen, Z., Li, F., Zhong, M.-M., & Xia, L.-J. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.10.0016 · Cited by 51

Hesperetin derivative-7 inhibits PDGF-BB-induced hepatic stellate cell activation and proliferation by targeting Wnt/β-catenin pathway

Lin, X., Kong, L., Huang, C., Ma, T., Meng, X., He, Y., Wang, Q., & Li, J. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.02.009 · Cited by 51

DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis

Yang, J., She, Q., Yang, Y., Tao, H., & Li, J. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.07.013 · Cited by 51

Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats

Li, J., Liu, P., Zhang, R., Cao, L., Qian, H., Liao, J., Xu, W. R., Wu, M., & Yin, Z.-F. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.06.030 · Cited by 50

Lack of IL-17 signaling decreases liver fibrosis in murine schistosomiasis japonica

Zhang, Y., Huang, D., Gao, W., Yan, J., Zhou, W., Hou, X., Liu, M., Ren, C., Wang, S., & Shen, J. (2015) · International Immunology · doi:10.1093/intimm/dxv017 · Cited by 49

NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis

Xu, T., Ni, M.-M., Xingli, Li, X., Meng, X., Huang, C., & Li, J. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.11.010 · Cited by 49

Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-γ expression and hampering miR-17-5p-activated canonical Wnt–β-catenin signaling

Hasan, H. F., Abdel-Rafei, M. K., & Galal, S. M. (2016) · Biochemistry and Cell Biology · doi:10.1139/bcb-2016-0142 · Cited by 49

Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis

Wu, Y., Bu, F., Yu, H., Li, W., Huang, C., Meng, X., Zhang, L., Ma, T., & Li, J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.12.002 · Cited by 49

The role of TRPV4 in fibrosis

Zhan, L., & Li, J. (2017) · Gene · doi:10.1016/j.gene.2017.10.067 · Cited by 49

Silymarin Decreases Connective Tissue Growth Factor to Improve Liver Fibrosis in Rats Treated with Carbon Tetrachloride

Tzeng, J., Chen, M., Chung, H., & Cheng, J. (2012) · Phytotherapy Research · doi:10.1002/ptr.4829 · Cited by 47

The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice

Geng, Y., Sun, Q., Li, W., Lu, Z., Xu, H., Shi, J., & Xu, Z. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600392 · Cited by 46

Mechanism of collagen resorption in reversible hepatic fibrosis

Hutterer, F., Rubin, E., & Pópper, H. (1964) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(64)90054-1 · Cited by 43

The anti-fibrotic effect of betulinic acid is mediated through the inhibition of NF-κB nuclear protein translocation

Wan, Y., Wu, Y., Lian, L., Xie, W.-X., Li, X., Ouyang, B.-Q., Bai, T., Li, Q., Yang, N., & Nan, J. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.01.002 · Cited by 43

Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis

Li, X., Wu, X., Xu, T., Li, X., Yang, Y., Li, W., Huang, C., Meng, X., & Li, J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.07.003 · Cited by 43

The role of PTEN in regulation of hepatic macrophages activation and function in progression and reversal of liver fibrosis

Cheng, Y., Tian, Y., Xia, J., Wu, X., Yang, Y., Li, X., Huang, C., Meng, X., Ma, T., & Li, J. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.01.005 · Cited by 43

γδ T cells in liver diseases

Wang, X., & Tian, Z. (2018) · Frontiers of Medicine · doi:10.1007/s11684-017-0584-x · Cited by 43

Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-β/Smad interference

Jiang, Y., Wang, C., Li, Y., Wang, X., An, J.-D., Wang, Y., & Wang, X. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.10.028 · Cited by 41

Epigenetic modifications by histone deacetylases: Biological implications and therapeutic potential in liver fibrosis

Chen, P., Huang, C., Meng, X., & Li, J. (2015) · Biochimie · doi:10.1016/j.biochi.2015.06.016 · Cited by 41

Urinary metabonomics study of the hepatoprotective effects of total alkaloids from Corydalis saxicola Bunting on carbon tetrachloride-induced chronic hepatotoxicity in rats using 1 H NMR analysis

Wu, F., Zheng, H., Yang, Z.-T., Cheng, B., Wu, J., Liu, X.-W., Tang, C., Lu, S., Chen, Z.-N., Song, F., et al. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.03.031 · Cited by 41

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

Hicks, D. F., Goossens, N., Blas‐García, A., Tsuchida, T., Wooden, B., Wallace, M. C., Nieto, N., Lade, A. G., Redhead, B., Cederbaum, A. I., et al. (2017) · Scientific Reports · doi:10.1038/srep42563 · Cited by 40

Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-κB Signaling

Wang, L., Yue, Z. D., Guo, M., Fang, L., Bai, L., Li, X., Tao, Y., Wang, S., Liu, Q., Zhi, D., et al. (2016) · BioMed Research International · doi:10.1155/2016/1068528 · Cited by 40

MicroRNA-145 Induces the Senescence of Activated Hepatic Stellate Cells through the Activation of P53 Pathway by ZEB2

Yang, J., Lu, Y., Yang, P., Chen, Q., Wang, Y., Ding, Q., Xu, T., Li, X., Li, C., Huang, C., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27521 · Cited by 40

Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway

Wu, X., Wang, Y., Wang, S., Xu, R., & Lv, X. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2016.12.017 · Cited by 39

Hepatoprotective effects of Dicliptera chinensis polysaccharides on dimethylnitrosamine-induced hepatic fibrosis rats and its underlying mechanism

Zhang, K., Gao, Y., Zhong, M., Xu, Y., Li, J., Chen, Y., Duan, X., & Zhu, H. L. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.12.053 · Cited by 39

Cucurbitacin‐B attenuates CC l4‐induced hepatic fibrosis in mice through inhibition of STAT ‐3

Sallam, A.-A. M., Esmat, A., & Abdel‐Naim, A. B. (2017) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13160 · Cited by 38

Wogonoside Shows Antifibrotic Effects in an Experimental Regression Model of Hepatic Fibrosis

Wang, Q., Wen, R., Lin, Q., Wang, N., Lü, P., & Zhu, X. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3751-4 · Cited by 38

Hesperetin Mitigates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting Extracellular Matrix and Cell Apoptosis via the TGF-β1/Smad Pathway

Kong, R., Wang, N., Luo, H. L., & Lü, J. (2018) · Current Molecular Medicine · doi:10.2174/1566524018666180608084947 · Cited by 37

Smad2 increases the apoptosis of activated human hepatic stellate cells induced by TRAIL

Xu, F., Zhou, D., Meng, X., Wang, X., Liu, C., Huang, C., Li, J., & Zhang, L. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.01.013 · Cited by 36

ASIC1a promotes high glucose and PDGF-induced hepatic stellate cell activation by inducing autophagy through CaMKKβ/ERK signaling pathway

Wang, Y.-H., Sun, Y., Zuo, L., Wang, Y., & Huang, Y. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.10.003 · Cited by 36

Ameliorative effect of grape seed proanthocyanidin extract on thioacetamide-induced mouse hepatic fibrosis

Li, J., Li­, ­., Li, S., He, B., Mi, Y., Cao, H., Zhang, C., & Li, L. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.07.019 · Cited by 36

Berberine Inhibition of Fibrogenesis in a Rat Model of Liver Fibrosis and in Hepatic Stellate Cells

Wang, N., Xu, Q., Tan, H. Y., Hong, M., Li, S., Yuen, M., & Feng, Y. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/8762345 · Cited by 36

DNA Methylation of PTGIS Enhances Hepatic Stellate Cells Activation and Liver Fibrogenesis

Pan, X., Yang, Y., Meng, H., Li, H.-D., Chen, X., Huang, H., Bu, F., Yu, H., Wang, Q., Huang, C., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00553 · Cited by 36

Chinese herbal formula Fuzheng Huayu alleviates CCl4-induced liver fibrosis in rats: a transcriptomic and proteomic analysis

Dong, S., Cai, F., Chen, Q., Song, Y., Sun, Y., Wei, B., Li, X., Hu, Y., Liu, P., & Su, S.-B. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.150 · Cited by 35

Melatonin Ameliorates Liver Fibrosis Induced by Carbon Tetrachloride in Rats via Inhibiting TGF-β1/Smad Signaling Pathway

Wang, Y., Hong, R.-T., Xie, Y., & Xu, J.-M. (2018) · Current Medical Science · doi:10.1007/s11596-018-1871-8 · Cited by 35

Fighting Liver Fibrosis with Naturally Occurring Antioxidants

Lin, L., Zhou, F., Shen, S., & Zhang, T. (2018) · Planta Medica · doi:10.1055/a-0757-0008 · Cited by 34

Role of NLRC5 in progression and reversal of hepatic fibrosis

Liu, X., Wu, Y., Yang, Y., Li, W., Huang, C., Meng, X., & Li, J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.01.012 · Cited by 32

Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway

Li, W., Chen, X., Yang, Y., Huang, H., Li, H.-D., Huang, C., Meng, X., & Li, J. (2016) · Toxicology · doi:10.1016/j.tox.2016.11.004 · Cited by 32

Exosomal miRNAs as Biomarkers in the Diagnosis of Liver Disease

Wang, S., Wang, J., & Lv, X. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0011 · Cited by 32

Potential protective effects of a traditional Chinese herb, Litsea coreana Levl., on liver fibrosis in rats

Huang, C., Ma, T., Meng, X., Lv, X., Zhang, L., Wang, J., & Li, J. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.62.02.0010 · Cited by 31

Paeoniflorin exerts protective effect on radiation-induced hepatic fibrosis in rats via TGF-β1/Smads signaling pathway.

Hu, Z., Qin, F., Gao, S., Zhen, Y., Huang, D., & Dong, L. (2018) · PubMed Central · Cited by 31

EPAC activation inhibits acetaldehyde-induced activation and proliferation of hepatic stellate cell via Rap1

Yang, Y., Yang, F., Wu, X., Lv, X., & Li, J. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0437 · Cited by 30

Effect of matrine on transforming growth factor β1 and hepatocyte growth factor in rat liver fibrosis model

Yu, J.-L., Li, J., Chengz, R.-G., Ma, Y., Wang, X., & Liu, J. (2014) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(14)60062-6 · Cited by 30

Octreotide attenuates hepatic fibrosis and hepatic stellate cells proliferation and activation by inhibiting Wnt/β-catenin signaling pathway, c-Myc and cyclin D1

Zhang, C., Liu, X., Sun, H., Meng, X., Bao, Y., Zhang, H.-P., Pan, F., & Zhang, C. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.08.005 · Cited by 28

Anti-Fibrotic Effects of Neferine on Carbon Tetrachloride-Induced Hepatic Fibrosis in Mice

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