Cited by 111Liver physiology and pathologyTraditional Chinese Medicine AnalysisFlavonoids in Medical Research

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Research progress on the anti-hepatic fibrosis action and mechanism of natural products

Shan, Liang, Liu, Zhenni, Ci, Leilei, Shuai, Chen, Lv, Xiongwen, Li, Jun·2019·International Immunopharmacology

DOI 10.1016/j.intimp.2019.105765

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Abstract

Hepatic fibrosis is the most common pathological feature of most chronic liver diseases, and its continuous deterioration gradually develops into liver cirrhosis and eventually leads to liver cancer. At present, there are many kinds of drugs used to treat liver fibrosis. However, Western drugs tend to only target single genes/proteins and induce many adverse reactions. Most of the mechanisms and active ingredients of traditional Chinese medicine (TCM) are not clear, and there is a lack of unified diagnosis and treatment standards. Natural products, which are characterized by structural diversity, low toxicity, and origination from a wide range of sources, have unique advantages and great potential in anti-liver fibrosis. This article summarizes the work done over the previous decade, on the active ingredients in natural products that are reported to have anti-hepatic fibrosis effects. The effective anti-hepatic fibrosis ingredients identified can be generally divided into flavonoids, saponins, polysaccharides and alkaloids. Mechanisms of anti-liver fibrosis include inhibition of liver inflammation, anti-lipid peroxidation injury, inhibition of the activation and proliferation of hepatic stellate cells (HSCs), modulation of the synthesis and secretion of pro-fibrosis factors, and regulation of the synthesis and degradation of the extracellular matrix (ECM). This review provides suggestions for the development of anti-hepatic fibrosis drugs.

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Authors: Shan, L., Liu, Z., Ci, L., Shuai, C., Lv, X., & Li, J.
Affiliations: Anhui Medical University (CN)
Corresponding author: Lv, Xiongwen
ORCID: Shan, Liang
Lv, Xiongwen
Li, Jun
Venue: International Immunopharmacology
Publisher: Elsevier BV
Published: 2019-10
Volume: 75
Pages: 105765
ISSN: 1567-5769 (ISSN-L)
DOI: 10.1016/j.intimp.2019.105765
OpenAlex: W2963885368
Cited by: 111
References: 115
Citations by year: 2026: 10 · 2025: 16 · 2024: 21 · 2023: 25 · 2022: 25 · 2021: 7 · 2020: 6 · 2019: 1
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: International Immunopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81270498)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Keywords: liver fibrosis, traditional Chinese medicine, flavonoids, saponins, polysaccharides, alkaloids, liver inflammation, lipid peroxidation, hepatic stellate cells, extracellular matrix, liver cirrhosis, drug development
MeSH terms: Animals, Biological Products, Humans, Liver Cirrhosis

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Research progress on the anti-hepatic fibrosis action and mechanism of natural products

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