Mapping of Pituitary Stress-Induced Gene Regulation Connects Nrcam to Negative Emotions
Open accessAbstract
Environmental stressors such as repeated social defeat may initiate powerful activation of subconscious parts of the brain. Here, we examine the consequences of such stress (induced by resident-intruder paradigm) on the pituitary gland. In male stressed vs. control rats, by RNA- and bisulfite DNA sequencing, we found regulation of genes involved in neuron morphogenesis and communication. Among these, Neuronal cell adhesion molecule ( Nrcam ) showed reduced transcription and reduced DNA methylation in a region corresponding to intron 1 in human NRCAM . Also, genetic variability in this area was associated with altered stress response in male humans exposed to repeated social defeat in the form of abusive supervision. Thus, our data show that the pituitary gene expression may be affected by social stress and that genetic variability in NRCAM intron 1 region influences stress-induced negative emotions. We hope our shared datasets will facilitate further exploration of the motions triggered by social stressors.
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Chronic isolation in female rats reduced the DRD1 gene expression in the amygdala, while increasing dopamine concentration in the VTA.
“For instance, chronic isolation in female rats reduced the DRD1 gene expression in the amygdala, while increasing dopamine concentration in the VTA.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [43]
Environmental stressors such as social defeat and isolation significantly alter gene expression in the brain.
“In laboratory settings, environmental stressors such as social defeat and isolation significantly alter gene expression in the brain.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [43]
Genetic variability in the NRCAM gene influences stress responses in humans exposed to abusive supervision.
“Social defeat stress in male rats affected pituitary gland gene expression related to neuron morphogenesis and communication, with genetic variability in the NRCAM gene influencing stress responses in humans exposed to abusive supervision [43,121].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [43]
Social defeat stress in male rats affected pituitary gland gene expression related to neuron morphogenesis and communication.
“Social defeat stress in male rats affected pituitary gland gene expression related to neuron morphogenesis and communication, with genetic variability in the NRCAM gene influencing stress responses in humans exposed to abusive supervision [43,121].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [43]
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References 58 · Cited by 9
- Authors
- Olsen, M. B., Sannes, A.-C., Yang, K., Nielsen, M. B., Einarsen, S. V., Christensen, J. O., Pallesen, S., Bjørås, M., & Gjerstad, J.
- Affiliations
- Oslo University Hospital (NO)
- National Institute of Occupational Health (NO)
- University of Bergen (NO)
- Corresponding author
- Olsen, Maria Belland
- ORCID
- Venue
- iScience
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 25
- Issue
- 9
- Pages
- 104953
- ISSN
- 2589-0042 (ISSN-L)
- PMC
- PMC9437855
- OpenAlex
- W4292343606
- Cited by
- 9
- References
- 58
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- iScience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- pituitary gland, social stress, repeated social defeat, resident-intruder paradigm, NrCAM, neuronal cell adhesion molecule, DNA methylation, gene expression regulation, intron 1 polymorphism, abusive supervision, negative emotions, stress response
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