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Cited by 21Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchHydrogels: synthesis, properties, applications

Biomaterializing the advances in uterine tissue engineering

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Wei, Zhangming, Hu, Yi, He, Xiang, Ling, Wen, Yao, Jinxin, Li, Zhenjuan, Wang, Qiru, Li, Liping·2022·iScience
DOI 10.1016/j.isci.2022.105657PMC PMC9758531
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Abstract

The uterus is considered to be a unique wound-healing model and distinguished by the repeated shedding of the endometrium and self-traceless regeneration. Common curettage, cesarean section, and other operations often cause endometrial and myometrial defects and obstetric and gynecological complications, leading to a high demand for uterine repair or partial replacement. However, the structure and function of the uterus are complicated. Functional uterine tissue engineering requires highly specialized biomaterials with a natural extracellular microenvironment. Currently, no biomaterial can fully simulate the structural and biomechanical properties of the uterus. Many efforts have been made to develop highly functional materials and tissue structures that may provide uterine tissue engineering constructs for reducing obstetric and gynecological complications. Continuous efforts will likely facilitate the development of scalable cells and biomaterial technologies for clinical use. This review summarizes the recent applications of biomaterials and tissue engineering in rebuilding a portion of or the entire uterus.

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  • Injuries to the uterus from obstetric procedures, infection, or curettage can result in intrauterine adhesions (Asherman's syndrome) or uterine wall defects, compromising reproductive function and pregnancy outcomes.

    “Concurrently, injuries to the uterus (from obstetric procedures, infection, or curettage) can result in intrauterine adhesions (Asherman’s syndrome) or uterine wall defects, which compromise reproductive function and pregnancy outcomes [4].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [4]

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Cited by

Sorted by citations

Authors
Wei, Z., Hu, Y., He, X., Ling, W., Yao, J., Li, Z., Wang, Q., & Li, L.
Affiliations
  • Central South University (CN)
  • First Affiliated Hospital of University of South China (CN)
  • Jinan University (CN)
Corresponding author
Li, Liping
ORCID
Venue
iScience
Publisher
Elsevier BV
Published
2022-12
Volume
25
Issue
12
Pages
105657
ISSN
2589-0042 (ISSN-L)
DOI
10.1016/j.isci.2022.105657
PMC
PMC9758531
OpenAlex
W4309892171
Cited by
21
References
3
Citations by year
2026: 6 · 2025: 6 · 2024: 8 · 2023: 1
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
Locations
  • iScience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Joint Fund of the National Natural Science Foundation of China and the Karst Science Research Center of Guizhou Province (81871217)
  • National Natural Science Foundation of China
  • Guangzhou Municipal Science and Technology Project (201904010390)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
biomaterials, endometrial regeneration, myometrial defect, uterine repair, extracellular matrix, wound healing, pregnancy complications, gynecologic complications, tissue-engineered constructs

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