Materials as stem cell regulators
Open accessAbstract
The stem cell/material interface is a complex, dynamic microenvironment in which the cell and the material cooperatively dictate one another's fate: the cell by remodelling its surroundings, and the material through its inherent properties (such as adhesivity, stiffness, nanostructure or degradability). Stem cells in contact with materials are able to sense their properties, integrate cues via signal propagation and ultimately translate parallel signalling information into cell fate decisions. However, discovering the mechanisms by which stem cells respond to inherent material characteristics is challenging because of the highly complex, multicomponent signalling milieu present in the stem cell environment. In this Review, we discuss recent evidence that shows that inherent material properties may be engineered to dictate stem cell fate decisions, and overview a subset of the operative signal transduction mechanisms that have begun to emerge. Further developments in stem cell engineering and mechanotransduction are poised to have substantial implications for stem cell biology and regenerative medicine.
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Mechanical properties in three-dimensional culture systems can have large effects on cell, organoid, tissue, and organ development.
“Finally, it has become increasingly clear that the mechanical properties in three-dimensional (3D) culture systems can have large effects on cell51, organoid52, tissue53, and organ development54,55.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [54]
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- Authors
- Murphy, W. L., McDevitt, T. C., & Engler, A. J.
- Affiliations
- University of Wisconsin System (US)
- Georgia Institute of Technology (US)
- University of California San Diego (US)
- Corresponding author
- Murphy, William L.
- Venue
- Nature Materials
- Published
- 2014-05-21
- Volume
- 13
- Issue
- 6
- Pages
- 547-557
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- PMC
- PMC4163547
- OpenAlex
- W1967188390
- Cited by
- 947
- References
- 122
- Citations by year
- 2026: 25 · 2025: 49 · 2024: 39 · 2023: 54 · 2022: 72 · 2021: 88 · 2020: 101 · 2019: 102 · 2018: 112 · 2017: 112 · 2016: 105 · 2015: 75 · 2014: 12 · 2013: 1
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-06-20)
- Open access
- green
- europepmc.org
- Locations
- Nature Materials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (1dp2od006460-01)
- National Heart, Lung, and Blood Institute (R21HL106529, R01HL093282)
- National Institute of General Medical Sciences (R01GM088291)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR062006, TR01 AR062006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- stem cell fate regulation, mechanotransduction, substrate stiffness, nanotopography, cell adhesion, chemical functionalization, signal transduction, cell-material interactions, stem cell engineering, regenerative medicine
- MeSH terms
- Animals, Biocompatible Materials, Humans, Stem Cells, Signal Transduction, Regenerative Medicine, Nanostructures, Cellular Microenvironment, Cell Engineering
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