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Cited by 62Periodontal Regeneration and TreatmentsBlood transfusion and managementMesenchymal stem cell research

The DOI matches its Crossref record; 207 of the 213 references it cites were found in a registry or an index.

The role of platelet-rich plasma in biomedicine: A comprehensive overview

Open access
Zhang, Zhixin, Liu, Peng, Xue, Xinmiao, Zhang, Zhiyu, Wang, Li, Jiang, Yvke, Zhang, Chi, Zhou, Hanwen, Lv, Shuhan, Shen, Weidong, Yang, Shiming, Wang, Fangyuan·2025·iScience
DOI 10.1016/j.isci.2024.111705PMC PMC11787504
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Abstract

Biomedicine has seen significant advancements in the 21st century, with platelet-rich plasma (PRP) playing a crucial role in clinical practice. This blood derivative, enriched with platelet components, has shown great potential for promoting tissue repair and regeneration. Its wide range of applications and the presence of anti-inflammatory and growth-promoting factors make it a valuable tool in the field of biomedicine. The exploration of PRP in clinical settings has been gaining momentum. Despite its cost-effectiveness, safety, and therapeutic efficacy, the widespread clinical adoption of PRP has been hindered by the absence of consistent preparation standards and standardized treatment protocols. This article provides a comprehensive analysis of the clinical uses, physiological roles, molecular mechanisms, and preparation techniques of PRP in biomedicine. The aim is to offer a thorough understanding of the potential applications and benefits of PRP in medical practice.

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Graphical abstract CC BY-NC-ND · PubMed Central
Figure 1 Platelet-rich plasma classification Note: The Dohan Ehrenfest classification divides platelet-rich plasma into 4 categories based on leukocyte and fibrin content. (1) P-PRP: low fibrin content and no leukocytes or low leukocyte content after activation. (2) L-PRP: low fibrin content and relatively high leukocyte content after activation. (3) P-PRF: platelet-rich fibrin rich or platelet-rich fibrin poor in leukocytes. (4) L-PRF: high fibrin and leukocyte content after activation.
Figure 1 Platelet-rich plasma classification Note: The Dohan Ehrenfest classification divides platelet-rich plasma into 4 categories based on leukocyte and fibrin content. (1) P-PRP: low fibrin content and no leukocytes or low leukocyte content after activation. (2) L-PRP: low fibrin content and relatively high leukocyte content after activation. (3) P-PRF: platelet-rich fibrin rich or platelet-rich fibrin poor in leukocytes. (4) L-PRF: high fibrin and leukocyte content after activation.CC BY-NC-ND · PubMed Central
Figure 2 Pattern of preparation for rat/human PRP Note: This procedure is a refinement of Landesberg’s two-step centrifugation method. (A) Demonstrates the process of preparing PRP in rats. (B) Demonstrates the process of preparing PRP in humans.
Figure 2 Pattern of preparation for rat/human PRP Note: This procedure is a refinement of Landesberg’s two-step centrifugation method. (A) Demonstrates the process of preparing PRP in rats. (B) Demonstrates the process of preparing PRP in humans.CC BY-NC-ND · PubMed Central

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Research works printed but not linked: 2

  1. Chen, 2024, Investigation of the effect of anticoagulants on platelet recovery, enrichment factor, PDGF, TGF-β1 and optimal dose in the preparation of platelet-rich plasma, Panminerva Med.
  2. He, 2020, Conservative treatment of patients with bladder genital tract fistula: Three case reports, Medicine (Baltim.), 99

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Metadata

Authors
Zhang, Z., Liu, P., Xue, X., Zhang, Z., Wang, L., Jiang, Y., Zhang, C., Zhou, H., Lv, S., Shen, W., Yang, S., & Wang, F.
Affiliations
  • Xidian University (CN)
  • Chinese PLA General Hospital (CN)
Corresponding author
  • Yang, Shiming
  • Wang, Fangyuan
ORCID
Venue
iScience
Publisher
Elsevier BV
Published
2025-02
Volume
28
Issue
2
Pages
111705
ISSN
2589-0042 (ISSN-L)
DOI
10.1016/j.isci.2024.111705
PMC
PMC11787504
OpenAlex
W4406071180
Cited by
48
References
213
Citations by year
2026: 24 · 2025: 23
FWCI
9.76
Type
journal article
Language
en
Open access
Licence
Locations
  • iScience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Key Research and Development Program of China (2020YFC2005203)
  • Key Technologies Research and Development Program (2022YFC2402701, 2022YFC2402704)
  • National Natural Science Foundation of China
  • National Natural Science Foundation of China-China Academy of General Technology Joint Fund for Basic Research (81820108009)
Topics
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Hematology › Blood transfusion and management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords
platelet-rich plasma, tissue regeneration, tissue repair, anti-inflammatory factors, growth factors, clinical application, standardized treatment protocol, molecular mechanisms

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