OCA-B regulation of B-cell development and function

Teitell, Michael A.

doi:10.1016/j.it.2003.08.002

Cited by 60T-cell and B-cell ImmunologyGenomics and Chromatin DynamicsImmunodeficiency and Autoimmune Disorders

OCA-B regulation of B-cell development and function

Teitell, Michael A.·2003·Trends in Immunology

DOI 10.1016/j.it.2003.08.002

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Abstract

The transcriptional co-activator OCA-B [for Oct co-activator from B cells, also known as OBF-1 (OCT-binding factor-1) and Bob1] is not required for B-cell genesis but does regulate subsequent B-cell development and function. OCA-B deficient mice show strain-specific, partial blocks at multiple stages of B-cell maturation and a complete disruption of germinal center formation in all strains, causing humoral immune deficiency and susceptibility to infection. OCA-B probably exerts its effects through the regulation of octamer-motif controlled gene expression. The OCA-B gene encodes two proteins of distinct molecular weight, designated p34 and p35. The p34 isoform localizes in the nucleus, whereas the p35 isoform is myristoylated and is bound to the cytoplasmic membrane. p35 can traffic to the nucleus and probably activates octamer-dependent transcription, although this OCA-B isoform might regulate B cells through membrane-related signal transduction.

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Kalina (2002) · doi:10.1002/1521-4141(200209)32:9

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Authors: Teitell, M. A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Teitell, Michael A.
ORCID: Teitell, Michael A.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2003-10
Volume: 24
Issue: 10
Pages: 546-553
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2003.08.002
OpenAlex: W1974662847
Cited by: 60
References: 79
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 7 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 3
FWCI: 0.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08ca074929-04)
National Cancer Institute (CA 74929, R01CA090571, CA90571)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords: OCA-B, BOB.1, B cell development, B cell maturation, germinal center formation, humoral immune deficiency, octamer motif, transcriptional coactivator, myristoylation, membrane-bound transcription factors, signal transduction
MeSH terms: Animals, Antibody Formation, B-Lymphocytes, Humans, Immune System, Signal Transduction, Trans-Activators

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OCA-B regulation of B-cell development and function

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