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CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns
Open accessAbstract
It is now well accepted that the innate immune system recognizes both damage (or danger)- and pathogen-associated molecular patterns (DAMP and PAMP, respectively) through pattern recognition receptors, such as Toll-like receptors (TLR) and/or Nod-like receptors (NLR). Less clear are whether and how the response to PAMP and DAMP are regulated differentially. The answers may reveal whether the primary goal of the immune system is to defend against infections or to alert the host of tissue injuries. We demonstrated recently that the host response to DAMP is controlled by a DAMP-CD24-Siglec axis. Here we propose a key role for the CD24-Siglec pathway in discriminating between DAMPs and PAMPs.
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“This may provide one mechanism by which the host immune system can modulate responses to DAMPs and distinguish DAMPs from PAMPs107.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [107]
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Items 101–147 of 147
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BackgroundSelf-citationSoluble CD24 is an inflammatory biomarker in early and seronegative rheumatoid arthritis
Zheng, X., Wang, P., Song, J., Tang, Y., Xie, Y., Jin, X., Zhu, D., Fang, X., Wei, C., Li, R., et al. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2246370 · Cited by 6
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ResultExploiting Phagocytic Checkpoints in Nanomedicine: Applications in Imaging and Combination Therapies
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“CD24 is also responsible for distinguishing between DAMPs and pathogen-associated molecular patterns (PAMPs) via the interactions with sialic acid-binding Ig-like lectin 10 (Siglec-10) (Liu et al., 2009).”
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Liu, Y., Chen, Y., Wang, L., Yu, D., Chen, P., Chen, S., & Gong, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-21775-z · Cited by 3
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InfluentialSelf-citationCharacterization of CD24+ T Cells and Their Cytokine Signature in Autoimmune Hepatitis
Karthikeyan, A., Dagar, S., Saini, A., Taneja, S., Mitra, S., Saikia, B., Minz, R. W., & Rani, L. (2025) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2025.103196 · Cited by 3
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Metadata
- Authors
- Liu, Y., Chen, G.-Y., & Zheng, P.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Liu, Yang
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 30
- Issue
- 12
- Pages
- 557-561
- ISSN
- 1471-4906 (ISSN-L)
- PMC
- PMC2788100
- OpenAlex
- W1979054778
- Cited by
- 147
- References
- 68
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 6 · 2022: 14 · 2021: 12 · 2020: 8 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 11 · 2012: 13
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ai064350-15)
- National Institute on Aging (R01AG036690)
- National Cancer Institute (R01CA112001, CA-58033, R01CA058033)
- National Institute of General Medical Sciences (RC1GM091648)
- National Institute of Allergy and Infectious Diseases (R01-AI064350, AI64350)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- CD24, Siglec-G, Siglec-10, damage-associated molecular patterns, pathogen-associated molecular patterns, innate immunity, pattern recognition receptors, Toll-like receptors, NOD-like receptors, tissue injury response
- MeSH terms
- Animals, Heat-Shock Proteins, Humans, Immunity, Innate, Lymphocyte Activation, Protein Binding, Lectins, Receptors, Pattern Recognition, Toll-Like Receptor 2, Toll-Like Receptor 4, Mice, CD24 Antigen, Nod1 Signaling Adaptor Protein, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Sialic Acid Binding Immunoglobulin-like Lectins
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