Sialoside-based pattern recognitions discriminating infections from tissue injuries
Open accessAbstract
Recognition of pathogens-associated molecular patterns (PAMPs) by Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLR) plays a critical role in protecting host against pathogens. In addition, TLR and NLR also recognize danger-associated molecular patterns (DAMPs) to initiate limited innate immune responses. While innate immune response to DAMPs may be important for tissue repairs and wound healing, it is normally well controlled to avoid autoimmune destruction. Recent data support a role for sialoside-based pattern recognition by members of the Siglec family to attenuate innate immunity. In particular, since CD24-Siglec 10/G interaction selectively dampens host response to DAMPs but not PAMPs, this sialoside-based pattern recognition may serve as a foundation to discriminate PAMPs from DAMPs.
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Inhibitory Siglec recognition of cell surface sialoglycans is a clear example of glycan-based self-associated molecular patterns (SAMPs), which may provide a mechanism for the host to discriminate between infectious nonself and noninfectious self.
“A clear example of glycan-based SAMPs has been reported in the form of inhibitory Siglec recognition of cell surface sialoglycans (962 -964), which may also provide a mechanism for the host to discriminate between infectious nonself and noninfectious self (965).”
From Biological roles of glycans (2017) · cites this paper as [964]
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Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works
“A clear example of glycan-based SAMPs has been reported in the form of inhibitory Siglec recognition of cell surface sialoglycans (962) (963) (964) , which may also provide a mechanism for the host to discriminate between infectious nonself and noninfectious self (965) .”
Background
- Authors
- Liu, Y., Chen, G.-Y., & Zheng, P.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Liu, Yang
- Zheng, Pan
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 23
- Issue
- 1
- Pages
- 41-45
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC3042481
- OpenAlex
- W2065405440
- Cited by
- 28
- References
- 51
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ai064350-15)
- National Institute on Aging (R01AG036690)
- National Cancer Institute (R01CA058033)
- National Institute of General Medical Sciences (RC1GM091648)
- National Institute of Allergy and Infectious Diseases (R01-AI064350)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- sialosides, Siglec-10, CD24, pattern recognition, innate immunity, damage-associated molecular patterns, pathogen-associated molecular patterns, Toll-like receptors, NOD-like receptors, RIG-I-like receptors, wound healing, autoimmune tolerance
- MeSH terms
- Animals, Humans, Immunity, Innate, Infections, Sugar Acids, CD24 Antigen
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