The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
B cell receptor signaling in chronic lymphocytic leukemia
Abstract
BCR signaling plays an important pathogenic role in chronic lymphocytic leukemia (CLL) and B cell lymphomas, based on structural restrictions of the BCR, and BCR-dependent survival and growth of the malignant B cells. In CLL and lymphoma subtypes, ligand-independent (“tonic”) and ligand-dependent BCR signaling have been characterized, which can involve mutations of BCR pathway components or be triggered by (auto-) antigens present in the tissue microenvironment. In CLL, based on high response rates and durable remissions in early-stage clinical trials, there is rapid clinical development of inhibitors targeting BCR-associated kinases (BTK, PI3Kδ), which will change treatment paradigms in CLL and other B cell malignancies. Here, we discuss the evolution of this field, from BCR-related prognostic markers, to mechanisms of BCR activation, and targeting of BCR-associated kinases, the emerging Achilles’ heel in CLL pathogenesis.
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“Additionally, RhoH was also found to promote ZAP−70-induced BCR signalling, which has been implicated in CLL [33,68,69,70].”
From The Role of RhoH in TCR Signalling and Its Involvement in Diseases (2021) · cites this paper as [69]
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Self-citationTargeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
Byrd, J. C., Furman, R. R., Coutre, S. E., Flinn, I. W., Burger, J. A., Blum, K. A., Grant, B., Sharman, J. P., Coleman, M., Wierda, W. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1215637 · Cited by 2,270
Self-citationTargeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma
Wang, M. L., Rule, S., Martin, P., Goy, A., Auer, R., Kahl, B. S., Jurczak, W., Advani, R. H., Romaguera, J. E., Williams, M. E., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1306220 · Cited by 1,685
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Self-citation
Research works printed but not linked: 2
- Sivina, 2011, CCL3 (MIP-1alpha) plasma levels and the risk for disease progression in chronic lymphocytic leukemia, Blood, 117, 1662, 10.1182/blood-2010-09-307249 · DOI
- Gobessi, 2009, Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells, Leukemia, 23, 686, 10.1038/leu.2008.346 · DOI · Paper page
Cited by
Targeting B cell receptor signalling in cancer: preclinical and clinical advances
Burger, J. A., & Wiestner, A. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.121 · Cited by 431
Self-citationPhosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
Compagno, M., Wang, Q., Pighi, C., Cheong, T.-C., Meng, F.-L., Poggio, T., Yeap, L.-S., Karaca, E., Blasco, R. B., Langellotto, F., et al. (2017) · Nature · doi:10.1038/nature21406 · Cited by 126
Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)
Komarova, N. L., Burger, J. A., & Wodarz, D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409362111 · Cited by 98
Self-citationTissino, E., Benedetti, D., Herman, S. E. M., ten Hacken, E., Ahn, I. E., Chaffee, K. G., Rossi, F. M., Dal Bo, M., Bulian, P., Bomben, R., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171288 · Cited by 92
Self-citationHanna, B. S., Roessner, P. M., Scheffold, A., Jebaraj, B. M. C., Demerdash, Y., Öztürk, S., Lichter, P., Stilgenbauer, S., & Seiffert, M. (2019) · Leukemia · doi:10.1038/s41375-018-0318-3 · Cited by 55
Metadata
- Authors
- Burger, J. A., & Chiorazzi, N.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 34
- Issue
- 12
- Pages
- 592-601
- ISSN
- 1471-4906
- PMC
- PMC3898793
- Cited by
- 327
- References
- 130
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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