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B cell receptor signaling in chronic lymphocytic leukemia

Burger, Jan A., Chiorazzi, Nicholas·2013·Trends in Immunology

DOI 10.1016/j.it.2013.07.002PMC PMC3898793

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Abstract

BCR signaling plays an important pathogenic role in chronic lymphocytic leukemia (CLL) and B cell lymphomas, based on structural restrictions of the BCR, and BCR-dependent survival and growth of the malignant B cells. In CLL and lymphoma subtypes, ligand-independent (“tonic”) and ligand-dependent BCR signaling have been characterized, which can involve mutations of BCR pathway components or be triggered by (auto-) antigens present in the tissue microenvironment. In CLL, based on high response rates and durable remissions in early-stage clinical trials, there is rapid clinical development of inhibitors targeting BCR-associated kinases (BTK, PI3Kδ), which will change treatment paradigms in CLL and other B cell malignancies. Here, we discuss the evolution of this field, from BCR-related prognostic markers, to mechanisms of BCR activation, and targeting of BCR-associated kinases, the emerging Achilles’ heel in CLL pathogenesis.

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See all 327

Authors: Burger, J. A., & Chiorazzi, N.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2013-12
Volume: 34
Issue: 12
Pages: 592-601
ISSN: 1471-4906
DOI: 10.1016/j.it.2013.07.002
PMC: PMC3898793
Cited by: 327
References: 130
Language: en

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B cell receptor signaling in chronic lymphocytic leukemia

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