The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
B7 family checkpoint regulators in immune regulation and disease
Open accessAbstract
Fine-tuning the immune response and maintaining tolerance to self antigens involves a complex network of co-stimulatory and co-inhibitory molecules. The recent FDA approval of ipilimumab, a monoclonal antibody blocking CTLA-4, demonstrates the impact of checkpoint regulators in disease. This is reinforced by ongoing clinical trials targeting not only CTLA-4, but also the PD-1 and B7-H4 pathways in various disease states. Recently two new B7 family inhibitory ligands, VISTA and B7-H6 were identified. Here we review recent understanding of B7 family members and their concerted regulation of the immune response to either self or foreign pathogens. We also discuss clinical developments in targeting these pathways in different disease settings, and introduce VISTA as a putative therapeutic target.
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Cites
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Metadata
- Authors
- Ceeraz, S., Nowak, E. C., & Noelle, R. J.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 34
- Issue
- 11
- Pages
- 556-563
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2062549560
- Cited by
- 307
- References
- 16
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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