The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction
Open accessAbstract
A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic insights into virus-host interaction. We developed a proteomic technique called "quantitative temporal viromics" (QTV), which employs multiplexed tandem-mass-tag-based mass spectrometry. Human cytomegalovirus (HCMV) is not only an important pathogen but a paradigm of viral immune evasion. QTV detailed how HCMV orchestrates the expression of >8,000 cellular proteins, including 1,200 cell-surface proteins to manipulate signaling pathways and counterintrinsic, innate, and adaptive immune defenses. QTV predicted natural killer and T cell ligands, as well as 29 viral proteins present at the cell surface, potential therapeutic targets. Temporal profiles of >80% of HCMV canonical genes and 14 noncanonical HCMV open reading frames were defined. QTV is a powerful method that can yield important insights into viral infection and is applicable to any virus with a robust in vitro model.
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Metadata
- Authors
- Weekes, M. P., Tomasec, P., Huttlin, E. L., Fielding, C. A., Nusinow, D., Stanton, R. J., Wang, E. C. Y., Aicheler, R., Murrell, I., Wilkinson, G. W. G., Lehner, P. J., & Gygi, S. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 157
- Issue
- 6
- Pages
- 1460-1472
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1979921905
- Cited by
- 431
- References
- 185
- FWCI
- 29.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Weekes, M. P., Tomasec, P., Huttlin, E. L., Fielding, C. A., Nusinow, D., Stanton, R. J., Wang, E. C. Y., Aicheler, R., Murrell, I., Wilkinson, G. W. G., Lehner, P. J., & Gygi, S. P. (2014). Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction. Cell. https://doi.org/10.1016/j.cell.2014.04.028
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