The DOI matches its Crossref record; 149 of the 152 references it cites were found in a registry or an index.
Senescence-associated inflammatory responses: aging and cancer perspectives
Abstract
Senescent cells, albeit not proliferating, are metabolically and transcriptionally active, thereby capable of affecting their microenvironment, notably via the production of inflammatory mediators. These mediators maintain and propagate the senescence process to neighboring cells, and then recruit immune cells for clearing senescent cells. Among the inflammatory cues are molecules with pronounced tumor-controlling properties, both growth and invasion factors and inhibitory factors, working directly or via recruited immune cells. These senescence-inflammatory effects also prevail within tumors, mediated by the senescent tumor cells and the senescent tumor stroma. Here, we review the course and impact of senescence-associated inflammatory responses in aging and cancer. We propose that controlling senescence-associated inflammation by targeting specific inflammatory mediators may have a beneficial therapeutic effect in treatment of cancer and aging-related diseases.
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“Of note, the local low-grade inflammation that characterizes aging is triggered by senescent cells and is intimately related to age-related diseases such as cardiovascular diseases and cancer (5, 291, 292).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [291]
In the citing paper
“have all been shown to be linked to sustained systemic inflammation7–16.”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [12]
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Immunothérapie et métabolisme tumorale
Benamor, S. B. (2017) · doi:10.70675/2e5cbde1zb4faz4320zbd12z0a2ba777228b
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Biomaterials regulate cellular senescence for the treatment of H. pylori-related gastric cancer
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Unveiling mechanisms and potential application of probiotics in chronic inflammation and aging
Gan, R., Yu, Y., Duan, S., Fu, C., Wang, K., Han, H., & Li, M. D. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107543
Shahouzehi, B., Jafari, H., & Rostamzadeh, F. (2026) · European Journal of Applied Physiology · doi:10.1007/s00421-026-06484-3
Metadata
- Authors
- Lasry, A., & Ben-Neriah, Y.
- Affiliations
- Hebrew University of Jerusalem (IL)
- ORCID
- Lasry, Audrey
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 36
- Issue
- 4
- Pages
- 217-228
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2152877666
- Cited by
- 408
- References
- 152
- Citations by year
- 2026: 13 · 2025: 29 · 2024: 35 · 2023: 49 · 2022: 46 · 2021: 54 · 2020: 48 · 2019: 32 · 2018: 35 · 2017: 41 · 2016: 19 · 2015: 7
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- senescence-associated inflammation, cellular senescence, aging, cancer, senescence-associated secretory phenotype, tumor microenvironment, immune cell recruitment, senolytics, inflammatory mediators, age-related diseases
- MeSH terms
- Aging, Humans, Inflammation, Neoplasms
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