Cited by 408Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsImmune cells in cancer

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Senescence-associated inflammatory responses: aging and cancer perspectives

Lasry, Audrey, Ben-Neriah, Yinon·2015·Trends in Immunology

DOI 10.1016/j.it.2015.02.009

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Abstract

Senescent cells, albeit not proliferating, are metabolically and transcriptionally active, thereby capable of affecting their microenvironment, notably via the production of inflammatory mediators. These mediators maintain and propagate the senescence process to neighboring cells, and then recruit immune cells for clearing senescent cells. Among the inflammatory cues are molecules with pronounced tumor-controlling properties, both growth and invasion factors and inhibitory factors, working directly or via recruited immune cells. These senescence-inflammatory effects also prevail within tumors, mediated by the senescent tumor cells and the senescent tumor stroma. Here, we review the course and impact of senescence-associated inflammatory responses in aging and cancer. We propose that controlling senescence-associated inflammation by targeting specific inflammatory mediators may have a beneficial therapeutic effect in treatment of cancer and aging-related diseases.

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“Of note, the local low-grade inflammation that characterizes aging is triggered by senescent cells and is intimately related to age-related diseases such as cardiovascular diseases and cancer (5, 291, 292).”
Background
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Saul, D., Kosinsky, R. L., Atkinson, E. J., Doolittle, M. L., Zhang, X., LeBrasseur, N. K., Pignolo, R. J., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32552-1 · Cited by 1,022
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See all 408

Authors: Lasry, A., & Ben-Neriah, Y.
Affiliations: Hebrew University of Jerusalem (IL)
ORCID: Lasry, Audrey
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2015-04
Volume: 36
Issue: 4
Pages: 217-228
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2015.02.009
OpenAlex: W2152877666
Cited by: 408
References: 152
Citations by year: 2026: 13 · 2025: 29 · 2024: 35 · 2023: 49 · 2022: 46 · 2021: 54 · 2020: 48 · 2019: 32 · 2018: 35 · 2017: 41 · 2016: 19 · 2015: 7
FWCI: 4.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Israel Science Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: senescence-associated inflammation, cellular senescence, aging, cancer, senescence-associated secretory phenotype, tumor microenvironment, immune cell recruitment, senolytics, inflammatory mediators, age-related diseases
MeSH terms: Aging, Humans, Inflammation, Neoplasms

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Senescence-associated inflammatory responses: aging and cancer perspectives

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