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Revisiting the Mechanisms of CNS Immune Privilege
Open accessAbstract
Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.
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“Additionally, while the CNS is considered an immune privileged site (Louveau et al., 2015) where inflammation and fibrosis are more subdued than elsewhere in the body, the peripheral nervous system develops the typical severity of FBR (Spearman et al., 2018).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Louveau et al., 2015
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Metadata
- Authors
- Louveau, A., Harris, T. H., & Kipnis, J.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Kipnis, Jonathan
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 36
- Issue
- 10
- Pages
- 569-577
- ISSN
- 1471-4906 (ISSN-L)
- PMC
- PMC4593064
- OpenAlex
- W1918237073
- Cited by
- 682
- References
- 105
- Citations by year
- 2026: 41 · 2025: 55 · 2024: 70 · 2023: 72 · 2022: 72 · 2021: 73 · 2020: 71 · 2019: 61 · 2018: 79 · 2017: 58 · 2016: 30
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG034113, R01AG034113, R37AG034113)
- National Institute of Neurological Disorders and Stroke (R01NS091067)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Keywords
- neuroimmune interactions, meningeal lymphatic system, cerebrospinal fluid drainage, deep cervical lymph nodes, peripheral immune system, CNS homeostasis, neurological disorders, neuroinflammation
- MeSH terms
- Animals, Central Nervous System, Central Nervous System Diseases, Humans, Immune System, Lymphatic Diseases, Lymphatic System
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