Cited by 686Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

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Revisiting the Mechanisms of CNS Immune Privilege

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Louveau, Antoine, Harris, Tajie H., Kipnis, Jonathan·2015·Trends in Immunology

DOI 10.1016/j.it.2015.08.006PMC PMC4593064

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Abstract

Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.

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Authors: Louveau, A., Harris, T. H., & Kipnis, J.
Affiliations: University of Virginia (US)
Corresponding author: Kipnis, Jonathan
ORCID: Louveau, Antoine
Harris, Tajie H.
Kipnis, Jonathan
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2015-10
Volume: 36
Issue: 10
Pages: 569-577
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2015.08.006
PMC: PMC4593064
OpenAlex: W1918237073
Cited by: 682
References: 105
Citations by year: 2026: 41 · 2025: 55 · 2024: 70 · 2023: 72 · 2022: 72 · 2021: 73 · 2020: 71 · 2019: 61 · 2018: 79 · 2017: 58 · 2016: 30
FWCI: 4.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG034113, R01AG034113, R37AG034113)
National Institute of Neurological Disorders and Stroke (R01NS091067)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Keywords: neuroimmune interactions, meningeal lymphatic system, cerebrospinal fluid drainage, deep cervical lymph nodes, peripheral immune system, CNS homeostasis, neurological disorders, neuroinflammation
MeSH terms: Animals, Central Nervous System, Central Nervous System Diseases, Humans, Immune System, Lymphatic Diseases, Lymphatic System

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Revisiting the Mechanisms of CNS Immune Privilege

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