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Cited by 578Immune cells in cancerNeutrophil, Myeloperoxidase and Oxidative MechanismsCancer, Stress, Anesthesia, and Immune Response

Neutrophils in the tumor microenvironment

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Powell, Davalyn R., Huttenlocher, Anna·2016·Trends in Immunology
DOI 10.1016/j.it.2015.11.008PMC PMC4707100
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Abstract

Neutrophils are the first responders to sites of acute tissue damage and infection. Recent studies suggest that in addition to neutrophil apoptosis, resolution of neutrophil inflammation at wounds can be mediated by reverse migration from tissues and transmigration back into the vasculature. In settings of chronic inflammation, neutrophils persist in tissues, and this persistence has been associated with cancer progression. However, the role of neutrophils in the tumor microenvironment remains controversial, with evidence for both pro- and anti-tumor roles. Here we review the mechanisms that regulate neutrophil recruitment and resolution at sites of tissue damage, with a specific focus on the tumor microenvironment. We discuss the current understanding as to how neutrophils alter the tumor microenvironment to support or hinder cancer progression, and in this context outline gaps in understanding and important areas of inquiry.

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  • Neutrophils represent a significant portion of cells in the TME, and their abundance has been linked to adverse prognostic outcomes in cancer patients.

    “Neutrophils represent a significant portion of cells in the TME (Swierczak et al., 2015; Powell and Huttenlocher, 2016), and their abundance has been linked to adverse prognostic outcomes in cancer patients (Hiramatsu et al., 2018; Schiffmann et al., 2019; Yin et al., 2019; Kim et al., 2022).”

    From Microphysiological systems as models for immunologically ‘cold’ tumors (2024) · cites this paper as Powell and Huttenlocher, 2016

    The section ‘Evidence of neutrophils’ pro-cancer role’ says neutrophils occur within tumors or surrounding tissues in many cancers, supporting their presence in the tumor microenvironment. It does not establish that they represent a significant portion of its cells. The adverse-prognosis clause is attached to other citations, not this one. (LLM, conf=0.82)

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Sorted by citations

Authors
Powell, D. R., & Huttenlocher, A.
Affiliations
University of Wisconsin–Madison (US)
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2016-01
Volume
37
Issue
1
Pages
41-52
ISSN
1471-4906 (ISSN-L)
DOI
10.1016/j.it.2015.11.008
PMC
PMC4707100
OpenAlex
W2220756562
Cited by
578
References
7
Citations by year
2026: 34 · 2025: 33 · 2024: 37 · 2023: 63 · 2022: 93 · 2021: 69 · 2020: 71 · 2019: 58 · 2018: 55 · 2017: 41 · 2016: 24
FWCI
3.76
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Cancer Research Institute
  • National Institutes of Health
  • National Cancer Institute (CA085862, R01CA085862)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Keywords
neutrophils, tumor microenvironment, neutrophil recruitment, neutrophil apoptosis, inflammation resolution, reverse migration, chronic inflammation, tumor progression, tissue damage
MeSH terms
Cell Movement, Inflammation, Macrophages, Neoplasms, Neovascularization, Pathologic, Neutrophils, Tumor Microenvironment, Carcinogenesis

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