The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Type I Interferon in Chronic Virus Infection and Cancer
Open accessAbstract
Type I interferons (IFN-Is) are emerging as key drivers of inflammation and immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; however, prolonged IFN-I signaling can lead to immune dysfunction. IFN-Is are also emerging as double-edged swords in cancer, providing necessary inflammatory signals, while initiating feedback suppression in both immune and cancer cells. Here, we review the proinflammatory and suppressive mechanisms potentiated by IFN-Is during chronic virus infections and discuss the similar, newly emerging dichotomy in cancer. We then discuss how this understanding is leading to new therapeutic concepts and immunotherapy combinations. We propose that, by modulating the immune response at its foundation, it may be possible to widely reshape immunity to control these chronic diseases.
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Cites
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Type I interferons and dendritic cells in cancer immunotherapy
(2019) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.06.001 · Cited by 124
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Metadata
- Authors
- Snell, L. M., McGaha, T. L., & Brooks, D. G.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 38
- Issue
- 8
- Pages
- 542-557
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2621003511
- Cited by
- 500
- References
- 12
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Snell, L. M., McGaha, T. L., & Brooks, D. G. (2017). Type I Interferon in Chronic Virus Infection and Cancer. Trends in Immunology. https://doi.org/10.1016/j.it.2017.05.005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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