The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.
The ‘cytokine storm’: molecular mechanisms and therapeutic prospects
Open accessAbstract
Cytokine storm syndrome has generally been described as a collection of clinical manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are associated with various pathologies, as observed in infectious diseases, certain acquired or inherited immunodeficiencies and autoinflammatory diseases, or following therapeutic interventions. Despite the role of CS in tissue damage and multiorgan failure, a systematic understanding of its underlying molecular mechanisms is lacking. Recent studies demonstrate a positive feedback loop between cytokine release and cell death pathways; certain cytokines, PAMPs, and DAMPs, can activate inflammatory cell death, leading to further cytokine secretion. Here, we discuss recent progress in innate immunity and inflammatory cell death, providing insights into the cellular and molecular mechanisms of CSs and therapeutics that might quell ensuing life-threatening effects.
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Cites
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Cited by
Wang, Y., & Kanneganti, T.-D. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.07.038 · Cited by 545
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Pandeya, A., & Kanneganti, T.-D. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.10.001 · Cited by 303
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Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations
Xu, J.-Q., Zhang, W.-Y., Fu, J.-J., Fang, X.-Z., Gao, C.-G., Li, C., Yao, L., Li, Q.-L., Yang, X.-B., Ren, L.-H., et al. (2024) · Military Medical Research · doi:10.1186/s40779-024-00581-0 · Cited by 37
Metadata
- Authors
- Karki, R., & Kanneganti, T.-D.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 42
- Issue
- 8
- Pages
- 681-705
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W3174877434
- Cited by
- 438
- References
- 207
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- green
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