The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes
Open accessAbstract
The innate immune system initiates cell death pathways in response to pathogens and cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis, and necroptosis). PANoptosis has been identified as an inflammatory, lytic cell death pathway driven by caspases and RIPKs that is regulated by PANoptosome complexes, making it distinct from other cell death pathways. Several PANoptosome complexes (including ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosomes) have been characterized to date. Furthermore, PANoptosis is implicated in infectious and inflammatory diseases, cancers, and homeostatic perturbations. Therefore, targeting its molecular components offers significant potential for therapeutic development. This review covers PANoptosomes and their assembly, PANoptosome-mediated cell death mechanisms, and ongoing progress in developing therapeutics that target PANoptosis.
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Cites
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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
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Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
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Metadata
- Authors
- Pandeya, A., & Kanneganti, T.-D.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2024-01
- Volume
- 30
- Issue
- 1
- Pages
- 74-88
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W4388686381
- Cited by
- 303
- References
- 137
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes. https://app.cochat.ai/papers/10.1016/j.molmed.2023.10.001
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- Pandeya, A., & Kanneganti, T.-D. (2024). Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2023.10.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
