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Cited by 538NF-κB Signaling PathwaysAdipokines, Inflammation, and Metabolic DiseasesImmune Response and Inflammation

NF-κB: blending metabolism, immunity, and inflammation

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Capece, Daria, Verzella, Daniela, Flati, Irene, Arboretto, Paola, Cornice, Jessica, Franzoso, Guido·2022·Trends in Immunology
DOI 10.1016/j.it.2022.07.004
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Abstract

The procurement and management of nutrients and ability to fight infections are fundamental requirements for survival. These defense responses are bioenergetically costly, requiring the immune system to balance protection against pathogens with the need to maintain metabolic homeostasis. NF-κB transcription factors are central regulators of immunity and inflammation. Over the last two decades, these factors have emerged as a pivotal node coordinating the immune and metabolic systems in physiology and the etiopathogenesis of major threats to human health, including cancer, autoimmunity, chronic inflammation, and others. In this review, we discuss recent advances in understanding how NF-κB-dependent metabolic programs control inflammation, metabolism, and immunity and how improved knowledge of them may lead to better diagnostics and therapeutics for widespread human diseases.

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  • NF-κB is activated by various stimuli, including TLR4 ligands and cytokines such as CD40, TNF-α, IL-1β, and BAFF within the bone marrow microenvironment.

    “NF-κB is activated by various stimuli, including Toll-like receptor 4 (TLR4) ligands and cytokines such as CD40, TNF-α, IL-1β, and B-cell activating factor (BAFF) within the bone marrow microenvironment.”

    From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [136]

  • NF-κB is a pivotal transcription factor implicated in MM pathogenesis, particularly in the bone marrow microenvironment.

    “NF-κB is a pivotal transcription factor implicated in MM pathogenesis, particularly in the bone marrow microenvironment.”

    From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [136]

  • NF-κB signaling is categorized into canonical and non-canonical pathways; the canonical pathway involves p50-RelA complexes regulated by IKKα, β, and γ, while the non-canonical pathway involves p52-RelB complexes regulated by IKKα.

    “NF-κB signaling is categorized into canonical and non-canonical pathways. In the canonical pathway, NF-κB1 (p50)-RelA (p65) complexes are activated and regulated by a trimeric complex consisting of IκB kinases (IKK) α, β, and γ. Conversely, the non-canonical pathway involves NF-κB2 (p52)-RelB complexes, regulated by a dimeric complex of IKKα [136, 137] (Fig. 1).”

    From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [136]

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Authors
Capece, D., Verzella, D., Flati, I., Arboretto, P., Cornice, J., & Franzoso, G.
Affiliations
  • University of L'Aquila (IT)
  • Imperial College London (GB)
Corresponding author
  • Capece, Daria
  • Franzoso, Guido
ORCID
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2022-09
Volume
43
Issue
9
Pages
757-775
ISSN
1471-4906 (ISSN-L)
DOI
10.1016/j.it.2022.07.004
OpenAlex
W4291000418
Cited by
538
References
6
Citations by year
2026: 109 · 2025: 169 · 2024: 162 · 2023: 89 · 2022: 9
FWCI
12.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Immunology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • Spiral (Imperial College London) (submittedVersion, other-oa)
Funders
  • Medical Research Council (MR/V027581/1, 07_DG_2022_02)
  • Cancer Research UK (C26587/A8839)
  • Compagnia di San Paolo
  • NIHR Imperial Biomedical Research Centre (P81135)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
NF-κB, metabolism, immunity, inflammation, immune-metabolic crosstalk, nutrient sensing, energy homeostasis, chronic inflammation, autoimmunity, cancer, transcription factors
MeSH terms
Homeostasis, Humans, Inflammation, Neoplasms, Autoimmunity, NF-kappa B

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