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E3 Ligase Rbx1 Orchestrates Thymus Development and Fate Determination of αβ-γδ T Cells

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N4BP1 is a nucleocytoplasmic shuttling protein and recognizes aggregates of the ubiquitin-like protein NEDD8 to protect cells under heat shock

Guo, X., Ke, Y., Chen, Y., Li, Y., Zhang, J., Zheng, W., Feng, P., Ji, Y., Wang, Z., Lu, Y., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110511 · Cited by 2 · see citing works

The ubiquitin conjugating enzyme E2 F (UBE2F)-RING-box protein 2 (RBX2)-mediated neddylation of Cullin5 facilitates pseudorabies virus replication

Zheng, Z., Zhao, F., Zhao, S., Bai, Y., Shi, L., Zhu, B., Huang, X., Zheng, Y., Zhao, Q., Wen, Y., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.150018 · Cited by 2 · see citing works

Cell-type-specific role of cullin 3 in adipocytes and hepatocytes: metabolic implications of neddylation inhibition

Yuan, Z., Wang, Z., Qin, T., & Yu, B. (2026) · Targetome · doi:10.48130/targetome-0025-0013 · Cited by 2 · see citing works

Design, synthesis, and evaluation of novel andrographolide derivatives as anti-pancreatic cancer therapeutics

Li, Y.-R., Chiang, P., Hou, S.-Y., Lin, C., Lo, L., & Fu, S. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109946 · Cited by 2 · see citing works

CRL3 E3 ligase regulates glutamine and cystine metabolisms

Zhou, Q., Li, Z., & Sun, Y. (2024) · Protein & Cell · doi:10.1093/procel/pwae051 · Cited by 2 · see citing works

Inhibition of cardiomyocyte neddylation impairs embryonic cardiac morphogenesis

Littlejohn, R., Zambrano-Carrasco, J., Zou, J., Yao, Y., Kim, I., Zhou, J., Li, J., & Su, H. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.10.006 · Cited by 2 · see citing works

Rapid proteasomal degradation of mutant feline McDonough sarcoma-like tyrosine kinase-3 overcomes tyrosine kinase inhibitor resistance of acute myeloid leukemia cellsPreprint

Halilovic, M., Abdelsalam, M. A. M., Mieland, A. O., Neuroth, S., Ashry, R., Zabkiewicz, J., Lazenby, M., Alvares, C. L., Schmidt, M., Brenner, W., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.20.660791 · Cited by 2 · see citing works

Fibroblast-targeted MLN4924 suppresses autoimmune myocarditis by dually modulating IL-17A and TGF-β pathways

Shen, W., Guo, F., Jiang, H., Gao, J., Chen, W., Yu, Z., Yuan, J., Huang, M., Zong, M., Li, M., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116206 · Cited by 1 · see citing works

Potential circadian rhythm-related pathogenic genes in coronary artery disease: a Mendelian randomization study

Zhang, H., Zhao, Z., Shi, W., Niu, G., Feng, D., Wang, M., Zhou, Z., Li, Z., Zhao, J., & Wu, Y. (2025) · Postgraduate Medical Journal · doi:10.1093/postmj/qgaf125 · Cited by 1 · see citing works

Conventional and alternative approaches for targeting PIK3CA and PTEN alterations in head and neck, breast, and other cancers

Gencel‐Augusto, J., Grandis, J. R., & Johnson, D. E. (2025) · Advances in Biological Regulation · doi:10.1016/j.jbior.2025.101117 · Cited by 1 · see citing works

Decorin Evokes a Pro‐Lysosomal Pathway in Lymphatic Endothelial Cells

Pascal, G. J., Mondal, D. K., Kim, S., Xie, C., Sankar, D. S., Dengjel, J., & Iozzo, R. V. (2025) · Proteoglycan Research · doi:10.1002/pgr2.70038 · Cited by 1 · see citing works

HIV proviral transcription and infectivity are enhanced by neddylation

Vaca, C. C., Hudson, H., Clerc, I., Song, C., & D’Aquila, R. T. (2025) · Journal of Virology · doi:10.1128/jvi.00968-25 · Cited by 1 · see citing works

Screening and regulatory mechanisms of biomarkers related to neddylation in laryngeal squamous cell carcinoma

Wang, X., Zhang, H., & Wang, J. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1654064 · Cited by 1 · see citing works

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Cui, D., Qu, R., Li, T., Wang, L., Chen, X., Shao, S., Liang, X., Xu, J., Sun, Y., Xiong, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202512652 · Cited by 1 · see citing works

Ecological History Shapes Transcriptome Variation in Quiescent Saccharomyces cerevisiae

Marek, A., Tomala, K., & Wloch‐Salamon, D. (2025) · Biomolecules · doi:10.3390/biom15111588 · Cited by 1 · see citing works

The Role of Ubiquitination and Deubiquitination in the Pathogenesis of Acute Kidney Injury: Progress in Research

Zhou, Y., Tao, S., Liu, L.-J., & Zhang, L. (2025) · Biomedicines · doi:10.3390/biomedicines13122873 · Cited by 2 · see citing works

NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease

Mitsiadou, D., Xirodimas, D. P., & Polanowska, J. (2025) · Essays in Biochemistry · doi:10.1042/ebc20253036 · Cited by 1 · see citing works

CUL4B promotes hepatocellular carcinoma progression and oxaliplatin resistance by facilitating FUS degradation

Wei, J., Cheng, K., Wu, X., Zhang, L., Wang, Q., Liang, Y., Zhu, Z., Meng, W., Chen, W., Guan, X., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08320-6 · Cited by 1 · see citing works

Roles of novel post-translational modifications in the male reproductive system: From regulation of reproductive development to therapeutic potential

Du, X.-R., Gao, Y., Zeng, Q., Zhang, G., & Liu, W. (2025) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2025.195132 · Cited by 1 · see citing works

Integration analysis of single-cell and spatial transcriptomics identifies prognostic genes associated with neddylation in colorectal cancer

Zhu, Z., Zhang, X., Wang, S., Huang, Y., Han, X., Lai, D., Yao, X., Lan, W., Nong, H., Zeng, W., et al. (2025) · Discover Oncology · doi:10.1007/s12672-025-04340-y · Cited by 1 · see citing works

FGFR signaling and neddylation facilitate SARS-CoV-2 infection by modulating interferon induction and viral entry, respectively

Felix-Lopez, A., López-Orozco, J., Elaish, M., Fayad, N., Xu, Z., Woldemariam, T. A., Hassan, B. B., Panigrahi, R. R., Khan, J. Q., Rohamare, M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.114566 · Cited by 1 · see citing works

Role of neddylation in diabetes metabolism: potential therapeutic target

Li, H., Zeng, R., Liu, J., & Wang, H. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01837-9 · Cited by 1 · see citing works

NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke via mediating neddylation of NRF2

Rao, W., Huang, Y., Li, J., Chen, Q., Sun, J., & Huang, L. (2026) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2026.108582 · Cited by 2 · see citing works

UFMylation: biological mechanisms, functions, and clinical implications

Wu, X., Yuan, Q., & Yin, Q. (2026) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2026.02.014 · Cited by 1 · see citing works

Neddylation-Mediated hnRNPA2B1 Degradation Aggravates Retinal Endothelial Cell Dysfunction in Diabetic Retinopathy by Regulating miR-93-5p/VEGFA

Chen, T., Zhou, J.-X., Hou, Y.-R., Zhang, Y.-N., Li, C., Zhu, J., Guo, Z., & Cui, Y. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.3.5 · Cited by 1 · see citing works

A guide to mapping ubiquitin and ubiquitin‐like E3 ligases to their substrates

Merino‐Cacho, L., Guinea-Pérez, C., Pozo-Rodríguez, M., Cano-López, S., Ramírez, J., Barroso‐Gomila, O., Mayor, U., Sutherland, J. D., & Barrio, R. (2026) · FEBS Journal · doi:10.1111/febs.70479 · Cited by 3 · see citing works

UBE2M promotes malignant phenotypes of prostate cancer through mediating NAA10 neddylation

Wang, Q., Zhang, J. L., Lin, X., Shi, R., Pan, C., Hu, Q., Xu, L., Chen, Q., Xue, D., Yin, J., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08001-8 · Cited by 1 · see citing works

Ubiquitin-like modifications in adipose tissue development and obesity: New insights

Chakraborty, S., & Chen, W. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168234 · Cited by 1 · see citing works

A universal strategy based on a multifunctional DNAzyme biomineralized nanodevice for imaging low-abundance proteins

Guo, W., Fan, M., Sun, Z., Huang, H., Mo, G., Luo, Z., Xu, J., Liang, L., & Wang, S. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152019 · Cited by 1 · see citing works

Neddylation of STAT3 is a potential therapeutic target for MASLD

Liu, F., Zhao, F., Du, M., Ma, J., Shang, Y., Liu, Z., Zhu, Y., Zhang, Z., & Xie, P. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168261 · Cited by 1 · see citing works

NSUN2/ALYREF stabilizes m5C-modified circCEP70 to enhance radioresistance in rectal cancer through NEDD8-dependent neddylation and ubiquitination regulation

Hu, Y., Shan, Z., Sun, X., Liang, J., Wang, L., Zhou, X., & Chen, X. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152388 · Cited by 1 · see citing works

UBE2M-mediated neddylation modification stabilizes VEGFR2 to delay pulmonary vascular endothelial cell senescence

Chang, Y., Qiao, C., Xu, X., Lyu, X., Xu, L., Hu, Q., Han, Y., Wu, Y., Zhang, X., Li, Q., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08881-0 · Cited by 1 · see citing works

Post-translational modifications as hubs of amino acid metabolism in cancer: From oncogenic signaling to therapeutic targeting

Xu, N., Shao, J., Jiang, L., Zhao, H., & Zheng, W. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189653 · Cited by 1 · see citing works

Protein neddylation as a therapeutic target: challenges and opportunities

Zhang, S., Lan, H., & Sun, Y. (2026) · Journal of Clinical Investigation · doi:10.1172/jci206924 · Cited by 1 · see citing works

Neddylation E2 enzyme UBE2M inhibits inflammatory lung tumor microenvironment by blocking the cGAS-STING signal upon KrasG12D activation

Zheng, Y., Chen, C. F., Li, X., Li, Z., Li, H., Tan, M., Zhai, D., Zhang, F., Lü, W., 陈志华, et al. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.08.050 · Cited by 1 · see citing works

Gill regeneration in the mayfly Cloeon uncovers new molecular pathways in insect regeneration

Martín-Blanco, C. A., Navarro, P., Esteban-Collado, J., Serras, F., Almudí, I., & Casares, F. (2024) · Open Biology · doi:10.1098/rsob.240118 · Cited by 1 · see citing works

NAE1 protein: a prognostic, immunomodulatory, and therapeutic biomarker associated with neddylation in hepatocellular carcinoma

Pan, Y., Dai, J., Liu, Y., Wang, Y., Zhang, Q., Lou, Y., & Qiu, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143539 · Cited by 1 · see citing works

Neddylation Regulates Mitochondrial Dynamics and Turnover in the Adult HeartPreprint

Zou, J., Wang, W., Chen, Q., Zhang, L., Zambrano-Carrasco, J., Li, Y., Lu, Y., Zhou, H., Dong, K., Fukai, T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.03.692150 · Cited by 1 · see citing works

Protein neddylation: substrate landscape and target modulators

Jing, Z., Wang, F., Li, H., Lu, B., Li, Z., Hu, W., Liang, S., 梁武龙, Fu, X., & Wang, X. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-09076-z

Protein neddylation: beyond cullin–RING ligases

Enchev, R. I., Schulman, B. A., & Peter, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3919 · Cited by 622 · see citing works

Introduction

Sun, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1025-0_1 · Cited by 13 · see citing works

Protein neddylation and its alterations in human cancers for targeted therapy

Zhou, L., Zhang, W., Sun, Y., & Jia, L. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.01.009 · Cited by 227 · see citing works

Anticancer drug discovery by targeting cullin neddylation

Yu, Q., Jiang, Y., & Sun, Y. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.09.005 · Cited by 77 · see citing works