The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment
Open accessAbstract
Lactic acid production has been regarded as a mechanism by which malignant cells escape immunosurveillance. Recent technological advances in mass spectrometry and the use of cell culture media with a physiological nutrient composition have shed new light on the role of lactic acid and its conjugate lactate in the tumor microenvironment. Here, we review novel work identifying lactate as a physiological carbon source for mammalian tumors and immune cells. We highlight evidence that its use as a substrate is distinct from the immunosuppressive acidification of the extracellular milieu by lactic acid protons. Together, data suggest that neutralizing the effects of intratumoral acidity while maintaining physiological lactate metabolism in cytotoxic CD8+ T cells should be pursued to boost anti-tumor immunity.
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Cites
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Cited by
Lactate and lactylation in cancer
Chen, J., Huang, Z., Chen, Y., Tian, H., Chai, P., Shen, Y., Yao, Y., Xu, S., Ge, S., & Jia, R. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02082-x · Cited by 477
Lactate: A key regulator of the immune response
Llibre, A., Kucuk, S., Gope, A., Certo, M., & Mauro, C. (2025) · Immunity · doi:10.1016/j.immuni.2025.02.008 · Cited by 283
Zhang, W., Jin, C., Liu, S., Wan, X., Li, Y., Liu, J., Duan, Z., Ma, J., & Gao, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1757513 · Cited by 22
Metadata
- Authors
- Apostolova, P., & Pearce, E. L.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 43
- Issue
- 12
- Pages
- 969-977
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W4307515422
- Cited by
- 346
- References
- 51
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Apostolova, P., & Pearce, E. L. (2022). Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment. Trends in Immunology. https://doi.org/10.1016/j.it.2022.10.005
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