Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system
Open accessAbstract
Single-cell technologies have recently allowed the identification of multiple lymphatic endothelial cell (LEC) subsets in subcapsular, paracortical, medullary, and other lymph node (LN) sinus systems in mice and humans. New analyses show that LECs serve key immunological functions in the LN stroma during immune responses. We discuss the roles of different LEC types in guiding leukocyte and cancer cell trafficking to and from the LN parenchyma, in capturing microbes, and in transporting, presenting, and storing lymph-borne antigens in distinct types of lymphatic sinuses. We underscore specific adaptations of human LECs and raise unanswered questions concerning LEC functions in human disease. Despite our limited understanding of human lymphatics - hampering clinical translation in inflammation and metastasis - we support the potential of LN LECs as putative targets for boosting/inhibiting immunoreactivity.
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The lymph node subcapsular sinus is lined by floor and ceiling LECs that are transcriptionally distinct.
“which is lined by floor and ceiling LECs that are transcriptionally distinct (88).”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [88]
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Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes
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Transport and Immune Functions of the Lymphatic System.
Davis, M. J., Zawieja, S. D., & King, P. D. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022724-104908 · Cited by 42 · see citing works
- Authors
- Takeda, A., Salmi, M., & Jalkanen, S.
- Affiliations
- University of Turku (FI)
- Corresponding author
- Jalkanen, Sirpa
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2023-01
- Volume
- 44
- Issue
- 1
- Pages
- 72-86
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W4310668394
- Cited by
- 48
- References
- 4
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 13 · 2023: 5
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Immunology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UTUPub (University of Turku) (submittedVersion, other-oa)
- Funders
- Jane ja Aatos Erkon Säätiö
- Sigrid Juséliuksen Säätiö
- Academy of Finland
- Syöpäjärjestöt
- Topics
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- lymphatic endothelial cells, lymph nodes, lymphatic sinuses, lymph node stroma, leukocyte migration, antigen capture, antigen transport, antigen presentation, inflammation, metastasis, immunotherapy targets
- MeSH terms
- Animals, Humans, Inflammation, Lymph Nodes, Lymphatic System, Lymphatic Vessels, Endothelial Cells, Mice
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