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Cited by 270Acne and Rosacea Treatments and EffectsNutritional Studies and DietDermatology and Skin Diseases

Milk consumption and acne in teenaged boys

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Adebamowo, Clement A., Spiegelman, Donna, Berkey, Catherine S., Danby, F. William, Rockett, Helaine H., Colditz, Graham A., Willett, Walter C., Holmes, Michelle D.·2008·Journal of the American Academy of Dermatology
DOI 10.1016/j.jaad.2007.08.049PMC PMC4391699
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Abstract

Objective We sought to examine the association between dietary dairy intake and teenaged acne among boys. Methods This was a prospective cohort study. We studied 4273 boys, members of a prospective cohort study of youths and of lifestyle factors, who reported dietary intake on up to 3 food frequency questionnaires from 1996 to 1998 and teenaged acne in 1999. We computed multivariate prevalence ratios and 95% confidence intervals for acne. Results After adjusting for age at baseline, height, and energy intake, the multivariate prevalence ratios (95% confidence interval; P value for test of trend) for acne comparing highest (>2 servings/d) with lowest (<1/wk) intake categories in 1996 were 1.16 (1.01, 1.34; 0.77) for total milk, 1.10 (0.94, 1.28; 0.83) for whole/2% milk, 1.17 (0.99, 1.39; 0.08) for low-fat (1%) milk, and 1.19 (1.01, 1.40; 0.02) for skim milk. Limitations Not all members of the cohort responded to the questionnaire. Acne assessment was by self-report and boys whose symptoms might have been part of an underlying disorder were not excluded. We did not adjust for steroid use and other lifestyle factors that may affect occurrence of acne. Conclusion We found a positive association between intake of skim milk and acne. This finding suggests that skim milk contains hormonal constituents, or factors that influence endogenous hormones, in sufficient quantities to have biological effects in consumers.

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  • 35.7% (10/28) of observational studies exclusively commented on the association between dairy and acne.

    “Overall, 35.7% (10/28) exclusively commented on the association between dairy and acne (Table II),24, 25, 26, 27, 28, 29, 30, 31, 32, 33”

    From Diet and acne: A systematic review (2022) · cites this paper as [26]

  • Adebamowo et al found a significant association between skim milk and acne but not between total milk, whole milk, 2% milk, or low-fat milk and acne.

    “One notable example is that Adebamowo et al26 found a significant association between skim milk and acne but not between total milk, whole milk, 2% milk, or low-fat milk and acne.”

    From Diet and acne: A systematic review (2022) · cites this paper as [26]

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Research works printed but not linked: 40

  1. Purvis D, Robinson E, Merry S, Watson P. Acne, anxiety, depression and suicide in teenagers: a cross-sectional survey of New Zealand secondary school students. J Paediatr Child Health. 2006; 42:793-6. [PubMed: 17096715]
  2. White GM. Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol. 1998; 39(Suppl):S34-7. [PubMed: 9703121]
  3. Chan JJ, Rohr JB. Acne vulgaris: yesterday, today and tomorrow. Australas J Dermatol. 2000; 41(Suppl):S69-72. [PubMed: 11105385]
  4. Smith RN, Mann NJ, Braue A, Makelainen H, Varigos GA. The effect of a high-protein, low glycemic load diet versus a conventional, high-glycemic load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial. J Am Acad Dermatol. 2007; 57:247-56. [PubMed: 17448569]
  5. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: a disease of Western civilization. Arch Dermatol. 2002; 138:1584-90. [PubMed: 12472346]
  6. Robinson HM. The acne problem. South Med J. 1949; 42:1050-60. [PubMed: 15394875]
  7. Adebamowo CA, Spiegelman D, Danby FW, Frazier AL, Willett WC, Holmes MD. High school dietary dairy intake and teenage acne. J Am Acad Dermatol. 2005; 52:207-14. [PubMed: 15692464]
  8. Adebamowo CA, Spiegelman D, Berkey CS, Danby FW, Rockett HH, Colditz GA, et al. Milk consumption and acne in adolescent girls. Dermatol Online J. 2006; 12:1. [PubMed: 17083856]
  9. Berkey CS, Rockett HR, Field AE, Gillman MW, Frazier AL, Camargo CA Jr, et al. Activity, dietary intake, and weight changes in a longitudinal study of preadolescent and adolescent boys and girls. Pediatrics. 2000; 105:E56. [PubMed: 10742377]
  10. Rockett HR, Wolf AM, Colditz GA. Development and reproducibility of a food frequency questionnaire to assess diets of older children and adolescents. J Am Diet Assoc. 1995; 95:336-40. [PubMed: 7860946]
  11. Rockett HR, Breitenbach M, Frazier AL, Witschi J, Wolf AM, Field AE, et al. Validation of a youth/adolescent food frequency questionnaire. Prev Med. 1997; 26:808-16. [PubMed: 9388792]
  12. Huberman M, Langholz B. Application of the missing-indicator method in matched case-control studies with incomplete data. Am J Epidemiol. 1999; 150:1340-5. [PubMed: 10604777]
  13. Miettinen, OS. Theoretical epidemiology. New York: Wiley; 1985. p. 231-3.
  14. Hartmann S, Lacorn M, Steinhart H. Natural occurrence of steroid hormones in food. Food Chem. 1998; 62:7-20.
  15. Donnet-Hughes A, Duc N, Serrant P, Vidal K, Schiffrin EJ. Bioactive molecules in milk and their role in health and disease: the role of transforming growth factor-beta. Immunol Cell Biol. 2000; 78:74-9. [PubMed: 10651932]
  16. Cordain L. Implications for the role of diet in acne. Semin Cutan Med Surg. 2005; 24:84-91. [PubMed: 16092796]
  17. Hoyt G, Hickey MS, Cordain L. Dissociation of the glycemic and insulinemic responses to whole and skimmed milk. Br J Nutr. 2005; 93:175-7. [PubMed: 15788109]
  18. de Wit JN. Nutritional and functional characteristics of whey proteins in food products. J Dairy Sci. 1998; 81:597-608. [PubMed: 9565865]
  19. Larsen, PR.; William, I.; Hardin, RI. Williams textbook of endocrinology. 10. Philadelphia: WB Saunders; 2003.
  20. Bouthegourd JC, Roseau SM, Makarios-Lahham L, Leruyet PM, Tome DG, Even PC. A preexercise alpha-lactalbumin-enriched whey protein meal preserves lipid oxidation and decreases adiposity in rats. Am J Physiol Endocrinol Metab. 2002; 283:E565-72. [PubMed: 12169450]
  21. Bouthegourd JC, Even PC, Gripois D, Tiffon B, Blouquit MF, Roseau S, et al. A CLA mixture prevents body triglyceride accumulation without affecting energy expenditure in Syrian hamsters. J Nutr. 2002; 132:2682-9. [PubMed: 12221229]
  22. Lassalle MW, Li H, Yamada H, Akasaka K, Redfield C. Pressure-induced unfolding of the molten globule of all-Ala alpha-lactalbumin. Protein Sci. 2003; 12:66-72. [PubMed: 12493829]
  23. Andersson AM, Skakkebaek NE. Exposure to exogenous estrogens in food: possible impact on human development and health. Eur J Endocrinol. 1999; 140:477-85. [PubMed: 10366402]
  24. Klein KO, Baron J, Colli MJ, McDonnell DP, Cutler GB Jr. Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. J Clin Invest. 1994; 94:2475-80. [PubMed: 7989605]
  25. Deplewski D, Rosenfield RL. Role of hormones in pilosebaceous unit development. Endocr Rev. 2000; 21:363-92. [PubMed: 10950157]
  26. Holmes MD, Pollak MN, Willett WC, Hankinson SE. Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev. 2002; 11:852-61. [PubMed: 12223429]
  27. Giovannucci E, Pollak M, Liu Y, Platz EA, Majeed N, Rimm EB, et al. Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men. Cancer Epidemiol Bio- markers Prev. 2003; 12:84-9.
  28. Cordain L, Eades MR, Eades MD. Hyperinsulinemic diseases of civilization: more than just syndrome X. Comp Biochem Physiol A Mol Integr Physiol. 2003; 136:95-112. [PubMed: 14527633]
  29. Heaney RP, McCarron DA, Dawson-Hughes B, Oparil S, Berga SL, Stern JS, et al. Dietary changes favorably affect bone remodeling in older adults. J Am Diet Assoc. 1999; 99:1228-33. [PubMed: 10524386]
  30. Nilsson M, Stenberg M, Frid AH, Holst JJ, Bjorck IM. Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: the role of plasma amino acids and incretins. Am J Clin Nutr. 2004; 80:1246-53. [PubMed: 15531672]
  31. Honegger A, Humbel RE. Insulin-like growth factors I and II in fetal and adult bovine serum: purification, primary structures, and immunological cross-reactivities. J Biol Chem. 1986; 261:569-75. [PubMed: 3941093]
  32. Xian CJ, Shoubridge CA, Read LC. Degradation of IGF-I in the adult rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein. J Endocrinol. 1995; 146:215-25. [PubMed: 7561632]
  33. Philipps AF, Dvorak B, Kling PJ, Grille JG, Koldovsky O. Absorption of milk-borne insulin-like growth factor-I into portal blood of suckling rats. J Pediatr Gastroenterol Nutr. 2000; 31:128-35. [PubMed: 10941963]
  34. Sorensen S, Solvsten H, Politi Y, Kragballe K. Effects of vitamin D3 on keratinocyte proliferation and differentiation in vitro: modulation by ligands for retinoic acid and retinoid X receptors. Skin Pharmacol. 1997; 10:144-52. [PubMed: 9287395]
  35. Otremski I, Lev-Ran M, Salama R, Edelstein S. The metabolism of vitamin D3 in response to testosterone. Calcif Tissue Int. 1997; 60:485-7. [PubMed: 9115169]
  36. Pearl A, Arroll B, Lello J, Birchall NM. The impact of acne: a study of adolescents' attitudes, perception and knowledge. N Z Med J. 1998; 111:269-71. [PubMed: 9734528]
  37. Ebling, FJG.; Cunliffe, WJ. Disorders of the sebaceous gland. 5. Oxford: Blackwell Scientific Publications; 1992.
  38. McNutt LA, Wu C, Xue X, Hafner JP. Estimating the relative risk in cohort studies and clinical trials of common outcomes. Am J Epidemiol. 2003; 157:940-3. [PubMed: 12746247]
  39. Barros AJD, Hirakata VN. Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol. 2003; 3:21. [PubMed: 14567763]
  40. Greenland, S.; Rothman, KJ. Introduction to stratified analysis. In: Rothman, KJ.; Greenland, S., editors. Modern epidemiology. 2. Philadelphia: Lippincott-Raven Publishers; 1998. p. 253-79.

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Authors
Adebamowo, C. A., Spiegelman, D., Berkey, C. S., Danby, F. W., Rockett, H. H., Colditz, G. A., Willett, W. C., & Holmes, M. D.
Affiliations
  • Harvard University (US)
  • Brigham and Women's Hospital (US)
  • Dartmouth College (US)
Corresponding author
Danby, F. William
ORCID
Venue
Journal of the American Academy of Dermatology
Publisher
Elsevier BV
Published
2008-05
Volume
58
Issue
5
Pages
787-793
ISSN
0190-9622 (ISSN-L)
DOI
10.1016/j.jaad.2007.08.049
PMC
PMC4391699
OpenAlex
W2058748486
Cited by
270
References
0
Citations by year
2026: 3 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 15 · 2020: 15 · 2019: 17 · 2018: 20 · 2017: 14 · 2016: 17 · 2015: 13 · 2014: 22 · 2013: 18 · 2012: 21
FWCI
20.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American Academy of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • Breast Cancer Research Foundation
  • Kellogg's
  • National Institutes of Health (46200, DK46200)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-46834, P30DK046200, R01DK046834, DK46200.)
Topics
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
acne, milk consumption, skim milk, dairy consumption, adolescent boys, dietary fat, endogenous hormones, acne prevalence
MeSH terms
Acne Vulgaris, Adolescent, Animals, Child, Diet Surveys, Humans, Male, Milk, Prospective Studies, Cohort Studies, Prevalence

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