CoChat
Sign Up
Cited by 111Blood Pressure and Hypertension StudiesEicosanoids and Hypertension PharmacologyRenin-Angiotensin System Studies

The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.

Aspirin Administered at Bedtime, But Not on Awakening, Has an Effect on Ambulatory Blood Pressure in Hypertensive Patients

Open access
Hermida, Ramón C., Ayala, Diana E., Calvo, Carlos, López, José E.·2005·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2004.08.071
Open this paper in CoChat — free account

Abstract

Objectives The purpose of this research was to investigate in untreated hypertensive patients the effects on ambulatory blood pressure (BP) of aspirin (ASA) administered at different times of the day.Background Previous studies have shown that ASA produces an administration time-dependent inhibition of angiotensin II. Low-dose ASA has also been shown to reduce BP when administered before bedtime, as opposed to upon awakening, in normotensive and hypertensive volunteers, and in pregnant women at high risk for preeclampsia.Methods We studied 328 untreated patients with grade 1 hypertension, 44.0 +/- 12.6 years of age, randomly divided into three groups: nonpharmacological hygienic-dietary recommendations, the same recommendations and ASA (100 mg/day) on awakening, or the same recommendations and ASA before bedtime. Blood pressure was measured every 20 min during the day and every 30 min at night for 48 consecutive h before and after 3 months of intervention.Results After three months of nonpharmacological intervention, there was a small and nonsignificant reduction of BP (<0.2 mm Hg; p = 0.648). Blood pressure was slightly elevated after aspirin on awakening (2.6/1.6 mm Hg in the 24-h mean of systolic/diastolic BP; p = 0.002). A significant BP reduction, however, was observed in the patients who received aspirin before bedtime (6.8/4.6 mm Hg in systolic/diastolic BP; p < 0.001).Conclusions This prospective trial documents a significant administration time-dependent effect of low-dose ASA on BP in untreated hypertensive patients. The timed administration of low-dose ASA could provide a valuable approach, beyond the secondary prevention of cardiovascular disease, in the added BP control of patients with mild essential hypertension.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2004.08.071

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 49 references

1 of the 49 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Items 101–111 of 111

Related

See all

Metadata

Authors
Hermida, R. C., Ayala, D. E., Calvo, C., & López, J. E.
Affiliations
  • Universidade de Vigo (ES)
  • Complejo Hospitalario Universitario de Santiago (ES)
Corresponding author
Hermida, Ramón C.
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2005-09
Volume
46
Issue
6
Pages
975-983
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2004.08.071
OpenAlex
W2055328140
Cited by
111
References
49
Citations by year
2026: 5 · 2025: 5 · 2024: 11 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 7 · 2012: 5
FWCI
3.65
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
aspirin, low-dose aspirin, bedtime administration, timing of drug administration, ambulatory blood pressure, essential hypertension, untreated hypertension, non-pharmacological treatment, blood pressure control
MeSH terms
Adult, Aged, Aspirin, Circadian Rhythm, Female, Humans, Hypertension, Male, Middle Aged, Prospective Studies, Blood Pressure Monitoring, Ambulatory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review