The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Meta-Analysis of Cardiovascular Outcomes Trials Comparing Intensive Versus Moderate Statin Therapy
Open accessAbstract
Objectives The purpose of this study was to conduct a meta-analysis that compares the reduction of cardiovascular outcomes with high-dose statin therapy versus standard dosing.Background Debate exists regarding the merit of more intensive lipid lowering with high-dose statin therapy as compared with standard-dose therapy.Methods We searched PubMed and article references for randomized controlled trials of intensive versus standard-dose statin therapy enrolling more than 1,000 patients with either stable coronary heart disease or acute coronary syndromes. Four trials were identified: the TNT (Treating to New Targets) and the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid-Lowering) trials involved patients with stable cardiovascular disease, and the PROVE IT-TIMI-22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction-22) and A-to-Z (Aggrastat-to-Zocor) trials involved patients with acute coronary syndromes. We carried out a meta-analysis of the relative odds on the basis of a fixed-effects model using the Mantel-Haenszel method for the major outcomes of death and cardiovascular events.Results A total of 27,548 patients were enrolled in the 4 large trials. The combined analysis yielded a significant 16% odds reduction in coronary death or myocardial infarction (p < 0.00001), as well as a significant 16% odds reduction of coronary death or any cardiovascular event (p < 0.00001). No difference was observed in total or non-cardiovascular mortality, but a trend toward decreased cardiovascular mortality (odds reduction 12%, p = 0.054) was observed.Conclusions Intensive lipid lowering with high-dose statin therapy provides a significant benefit over standard-dose therapy for preventing predominantly non-fatal cardiovascular events.
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In the citing paper
“Such small changes in LDL-C levels do not seem to affect cardiovascular outcomes and serum lipid profiles with statin administration, which can reduce the LDL-C level by approximately 50 mg/dL (40).”
From Saturated Fat Restriction for Cardiovascular Disease Prevention: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2025) · cites this paper as [40]
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In the citing paper
“Such small changes in LDL-C levels do not seem to affect cardiovascular outcomes and serum lipid profiles with statin administration, which can reduce the LDL-C level by approximately 50 mg/dL (40).”
From Saturated Fat Restriction for Cardiovascular Disease Prevention: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2025) · cites this paper as [40]
Experimental — accuracy not yet measuredIn the citing paper
“Importantly, DM confers excess mortality risk following ACS despite modern therapies”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [409]
In the citing paper
“No increases in new-incidence cancer or non-CVD deaths were observed, which reconfirms the safety of long-term LDL-C-lowering therapy using statins.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [629]
In the citing paper
“The long-term follow-up of large clinical trials of statins that were conducted in the 1990s, such as the West of Scotland Coronary Prevention Study (WOSCOPS) and the Heart Protection Study (HPS)628, 629) confirmed that early initiation of LDLC-lowering therapy regardless of the plasma LDL-C level was useful for the long-term prevention of cardiovascular events and all-cause mortality in high-risk”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [629]
In the citing paper
“Large clinical trials investigating the effects of intensive LDL lowering with statins have demonstrated a substantial benefit over standard-dose statin therapy for preventing non-fatal cardiovascular events74.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [74]
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Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Collaboration, A. T. (2002) · BMJ · doi:10.1136/bmj.324.7329.71 · Cited by 6,943
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902
Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes
Cannon, C. P., Braunwald, E., McCabe, C. H., Rader, D. J., Rouleau, J. L., Belder, R., Joyal, S. V., Hill, K. A., Pfeffer, M. A., & Skene, A. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040583 · Cited by 4,938
Self-citationSever, P., Dahlöf, B., Poulter, N. R., Wedel, H., Beevers, G., Caulfield, M. J., Collins, R., Kjeldsen, S. E., Kristinsson, A., McInnes, G. T., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12948-0 · Cited by 3,790
Colhoun, H. M., Betteridge, D. J., Durrington, P. N., Hitman, G. A., W Neil, H. A., Livingstone, S. J., Thomason, M. J., Mackness, M. I., Charlton-Menys, V., & Fuller, J. H. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16895-5 · Cited by 3,755
Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease
LaRosa, J. C., Grundy, S. M., Waters, D. D., Shear, C., Barter, P., Fruchart, J.-C., Gotto, A. M., Greten, H., Kastelein, J. J. P., Shepherd, J., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050461 · Cited by 3,489
Shepherd, J., Blauw, G. J., Murphy, M. B., Bollen, E. L., Buckley, B. M., Cobbe, S. M., Ford, I., Gaw, A., Hyland, M., Jukema, J. W., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11600-x · Cited by 3,378
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- Steinberg, 2006, Statin use and low-density lipoprotein cholesterol goals in 2004, J Am Coll Cardiol, 47, 209A
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Sorted by citations
Items 201–300 of 772
Penno, G., Solini, A., Zoppini, G., Fondelli, C., Trevisan, R., Vedovato, M., Gruden, G., Lamacchia, O., Pontiroli, A. E., Arosio, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125512 · Cited by 43
Relative safety profiles of high dose statin regimens
Barrios, V. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s2048 · Cited by 43
Lipid-lowering therapy: who can benefit
Lewis, S. J. (2011) · Vascular Health and Risk Management · doi:10.2147/vhrm.s23113 · Cited by 44
Nanomedicine in coronary artery disease
Ambesh, P., Campia, U., Obiagwu, C., Bansal, R., Shetty, V., Hollander, G. M., & Shani, J. (2017) · Indian Heart Journal · doi:10.1016/j.ihj.2017.02.007 · Cited by 43
Targeting Inflammation After Myocardial Infarction
Mahtta, D., Sudhakar, D., Koneru, S., Silva, G. V., Alam, M., Virani, S. S., & Jneid, H. M. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-01358-2 · Cited by 43
Insulin Prevents Hypercholesterolemia by Suppressing 12α-Hydroxylated Bile Acids
Semova, I., Levenson, A. E., Krawczyk, J., Bullock, K. H., Gearing, M. E., Ling, A. V., Williams, K., Miao, J., Adamson, S. S., Shin, D., et al. (2022) · Circulation · doi:10.1161/circulationaha.120.045373 · Cited by 43
Lp(a): a New Pathway to Target?
Nurmohamed, N. S., Kraaijenhof, J. M., & Stroes, E. S. G. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01060-4 · Cited by 43
for the BIP Study Group, Arbel, Y., Klempfner, R., Erez, A., Goldenberg, I., Benzekry, S., Shlomo, N., Fisman, E. Z., & Tenenbaum, A. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0332-6 · Cited by 40
Rubenfire, M., Brook, R. D., & Rosenson, R. S. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.03.024 · Cited by 40
Nishikido, T., Oyama, J., Keida, T., Ohira, H., & Node, K. (2015) · Journal of Cardiology · doi:10.1016/j.jjcc.2015.05.017 · Cited by 40
Dose-related Effect of Statins in Venous Thrombosis Risk Reduction
Khemasuwan, D., Chae, Y. K., Gupta, S., Carpio, A., Yun, J. H., Neagu, Ş. I., Bianchi, A. L., Valsecchi, M. E., & Mora, J. I. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.04.019 · Cited by 40
Naci, H., Brugts, J. J., Fleurence, R., & Ades, A. E. (2013) · QJM · doi:10.1093/qjmed/hct041 · Cited by 38
Understanding IMPROVE-IT and the cardinal role of LDL-C lowering in CVD prevention
Laufs, U., Descamps, O. S., Catapano, A. L., & Packard, C. J. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu228 · Cited by 38
Marchioli, R., Levantesi, G., Silletta, M. G., Barlera, S., Bernardinangeli, M., Carbonieri, E., Cosmi, F., Franzosi, M. G., Latini, R., Lucci, D., et al. (2009) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.09.70 · Cited by 40
Secondary prevention after coronary artery bypass graft surgery
Kulik, A. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000331 · Cited by 40
Ara, R., Pandor, A., Stevens, J., Rees, A., & Rafia, R. (2009) · Health Technology Assessment · doi:10.3310/hta13340 · Cited by 40
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Robinson, J. G. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.488219 · Cited by 38
Potentially inappropriate medications and adverse drug effects in elders in the ED
Nixdorff, N., Hustey, F. M., Brady, A. K., Vaji, K., Leonard, M. C., & Messinger‐Rapport, B. J. (2008) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2007.12.007 · Cited by 39
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009) · doi:10.1002/9780470743386.ch1 · Cited by 39
Optimal Management of Combined Dyslipidemia: What Have We Behind Statins Monotherapy?
Tenenbaum, A., Fisman, E. Z., Motro, M., & Adler, Y. (2008) · Advances in cardiology · doi:10.1159/000115192 · Cited by 38
Fuentes, F. J., Alcala-Diaz, J. F., Watts, G. F., Rodrigo Alonso, K., Muñiz-Grijalvo, O., Díaz-Díaz, J. L., Mata, N., Muñoz-Torrero, J. F. S., Brea, Á., Galiana, J., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.07.107 · Cited by 38
Choi, J. Y., Choi, C. U., Hwang, S.-Y., Choi, B. G., Jang, W. Y., Kim, D. Y., Kim, W., Park, E. J., Lee, S., Na, J. O., et al. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.06.017 · Cited by 37
Pastori, D., Baratta, F., Rocco, A. D., Farcomeni, A., Ben, M. D., Angelico, F., Violi, F., Pignatelli, P., & Lip, G. Y. H. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105418 · Cited by 37
Chan, D. C., Pang, J., & Watts, G. F. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-014-0472-7 · Cited by 38
Agouridis, A. P., Rizos, C. V., Elisaf, M., & Filippatos, T. D. (2013) · The Review of Diabetic Studies · doi:10.1900/rds.2013.10.171 · Cited by 36
Rockberg, J., Jørgensen, L., Taylor, B., Sobocki, P., & Johansson, G. (2017) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2017.03.001 · Cited by 35
Cardiovascular Benefit of Magnitude of Low-Density Lipoprotein Cholesterol Reduction
Rahilly‐Tierney, C. R., Lawler, E. V., Scranton, R. E., & Gaziano, J. M. (2009) · Circulation · doi:10.1161/circulationaha.108.846931 · Cited by 35
Slipczuk, L. N., Blankstein, R., Bucciarelli‐Ducci, C., Braun, L. T., Phillips, L. M., Piña, P., Shaw, L. J., Tamis‐Holland, J. E., Williamson, E. E., & Virani, S. S. (2025) · Circulation · doi:10.1161/cir.0000000000001394 · Cited by 38
Mark, D. B., Knight, J. D., Cowper, P. A., Davidson-Ray, L. D., & Anstrom, K. J. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.05.032 · Cited by 34
Primary and Secondary Prevention of Coronary Heart Disease
Gaziano, J. M., Ridker, P. M., & Libby, P. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00049-4 · Cited by 34
Thalmann, I., Preiss, D., Schlackow, I., Gray, A. M., & Mihaylova, B. (2022) · Heart · doi:10.1136/heartjnl-2022-321452 · Cited by 36
Residual risks and evolving atherosclerotic plaques
Noothi, S. K., Ahmed, M. R., & Agrawal, D. K. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04689-0 · Cited by 37
Statins in Acute Coronary Syndromes
Morrissey, R. P., Diamond, G. A., & Kaul, S. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.093 · Cited by 35
Dyslipidemia: Management Using Optimal Lipid-Lowering Therapy
Ito, M. K. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1r127 · Cited by 34
Lipid-lowering therapy and coronary artery bypass graft surgery
Kulik, A., & Ruel, M. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32834b9fb1 · Cited by 33
Prevalence and types of persistent dyslipidemia in patients treated with statins
Reiner, Ž., & Tedeschi-Reiner, E. (2013) · Croatian Medical Journal · doi:10.3325/cmj.2013.54.339 · Cited by 33
Vimalananda, V. G., Miller, D. R., Hofer, T. P., Holleman, R. G., Klamerus, M. L., & Kerr, E. A. (2013) · Journal of General Internal Medicine · doi:10.1007/s11606-013-2340-5 · Cited by 34
Robinson, J. G. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.11.060 · Cited by 33
Lenglet, S., Quercioli, A., Fabre, M., Galan, K., Pelli, G., Nencioni, A., Bauer, I., Pende, A., Python, M., Bertolotto, M. B., et al. (2014) · Mediators of Inflammation · doi:10.1155/2014/720987 · Cited by 32
The Effect of Simvastatin on Glucose Homeostasis in Streptozotocin Induced Type 2 Diabetic Rats
Wang, L., Duan, G., Lu, Y., Pang, S., Huang, X., Jiang, Q., & Dang, N. (2013) · Journal of Diabetes Research · doi:10.1155/2013/274986 · Cited by 32
Ohno, Y., Miyoshi, T., Noda, Y., Oe, H., Toh, N., Nakamura, K., Kohno, K., Morita, H., & Ito, H. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-71 · Cited by 31
Rinfret, S., Behlouli, H., Eisenberg, M. J., Humphries, K. H., Tu, J. V., & Pilote, L. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.09.004 · Cited by 31
Mok, T. (2010) · The HKU Scholars Hub (University of Hong Kong) · Cited by 31
Colivicchi, F., Marco Tubaro, U., & Santini, M. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.07.006 · Cited by 30
Constance, C. M., Ben‐Yehuda, O., WENGER, N. K., Zieve, F. J., Lin, J., Hanson, M. E., Lowe, R. S., & Tershakovec, A. M. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-13 · Cited by 30
Padala, S. K., Sidhu, M. S., & Boden, W. E. (2016) · Springer eBooks · doi:10.1007/978-3-642-37393-0_70-2 · Cited by 30
Zhang, T., Shi, H., Liu, N., Tian, J., Zhao, X., Steer, C. J., Han, Q., & Song, G. (2020) · Theranostics · doi:10.7150/thno.39578 · Cited by 31
Dyslipidemia and prevention of atherosclerotic cardiovascular disease in the elderly
LUCCHI, T. (2022) · Minerva Medica · doi:10.23736/s0026-4806.21.07347-x · Cited by 33
Pharmacotherapy of Diabetes: New Developments
Mogensen, C. E. (2007) · Springer eBooks · doi:10.1007/978-0-387-69737-6 · Cited by 30
Soran, H., Adam, S., & Durrington, P. N. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316667785 · Cited by 29
von Eckardstein, A. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.6 · Cited by 30
Frishman, W. H. (2007) · Yearbook of Medicine · doi:10.1016/s0084-3873(08)70201-3 · Cited by 29
Morrow, D. A., & Boden, W. E. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00057-3 · Cited by 28
HDL metabolism in context: looking on the bright side
Watts, G. F., Barrett, P. H. R., & Chan, D. C. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328306596d · Cited by 30
Kajinami, K., & Yasusyuki, K. (2011) · Drug Design Development and Therapy · doi:10.2147/dddt.s13492 · Cited by 28
Zannad, F. M., Dallongeville, J., MacFadyen, R. J., Ruilope, L. M., Wilhelmsen, L., Backer, G. D., Graham, I. M., Lorenz, M., Mancia, G., Morrow, D. A., et al. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711424873 · Cited by 28
Yu, S., Jin, J., Chen, Z., & Luo, X. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01369-6 · Cited by 28
The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Hyperlipidemia
Farnier, M. (2011) · American Journal of Cardiovascular Drugs · doi:10.2165/11590330-000000000-00000 · Cited by 29
Non-ST Elevation Acute Coronary Syndromes: A Comprehensive Review
Bob‐Manuel, T., Ifedili, I., Reed, G. L., Ibebuogu, U. N., & Khouzam, R. N. (2017) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2017.04.006 · Cited by 33
Simvastatin: present and future perspectives
Robinson, J. G. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.13.2159 · Cited by 32
Lee, Y., Hong, B., Yun, K. H., Kang, W. C., Hong, S. J., Lee, S., Lee, S., Hong, S., Ahn, C., Kim, J., et al. (2024) · JAMA Cardiology · doi:10.1001/jamacardio.2024.3911 · Cited by 27
Cykert, S., Keyserling, T. C., Pignone, M. P., DeWalt, D. A., Weiner, B. J., Trogdon, J. G., Wroth, T. H., Halladay, J. R., Mackey, M., Fine, J. P., et al. (2020) · Health Services Research · doi:10.1111/1475-6773.13571 · Cited by 27
Plaisance, E. P., Grandjean, P. W., & Mahurin, A. J. (2009) · The Physician and Sportsmedicine · doi:10.3810/psm.2009.04.1678 · Cited by 27
Wiviott, S. D., & Cannon, C. P. (2006) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328010872d · Cited by 27
Self-citationFang, J., Wang, E.-Q., Wang, W., Liu, Y., & Cheng, G. (2017) · Internal and Emergency Medicine · doi:10.1007/s11739-017-1650-8 · Cited by 27
Statins in the spectrum of neurologic disease
Orr, J. D. (2008) · Current Atherosclerosis Reports · doi:10.1007/s11883-008-0003-5 · Cited by 27
Kang, S., Liu, Y., & Liu, X. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.06.006 · Cited by 26
Zhong, P., Wu, D., Ye, X., Wu, Y., Li, T., Tong, S., & Liu, X. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s135785 · Cited by 27
Miyauchi, K., & Daida, H. (2010) · Circulation Journal · doi:10.1253/circj.cj-10-0565 · Cited by 26
Geographic Variation in Statin Use for Complex Acute Myocardial Infarction Patients
Brooks, J. M., Cook, E. A., Chapman, C. G., Kulchaitanaroaj, P., Chrischilles, E. A., Welch, S., & Robinson, J. G. (2014) · Medical Care · doi:10.1097/mlr.0b013e3182a7fc3d · Cited by 26
Clinical review: Impact of statin substitution policies on patient outcomes
Atar, D., Carmena, R., Clemmensen, P. M., Laflamme, A. K., Waßmann, S., Lansberg, P. J., & Hobbs, R. F. (2009) · Annals of Medicine · doi:10.1080/07853890902729786 · Cited by 26
The Science of Ischemic Stroke: Pathophysiology & Pharmacological Treatment
Kanyal, N. (2015) · International journal of pharma research and review · Cited by 26
Are post-treatment low-density lipoprotein subclass pattern analyses potentially misleading?
Bays, H. E., Conard, S. E., Leiter, L. A., Bird, S. R., Jensen, E. H., Hanson, M. E., Shah, A. K., & Tershakovec, A. M. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-136 · Cited by 25
Sakuma, M., Iimuro, S., Shinozaki, T., Kimura, T., Nakagawa, Y., Ozaki, Y., Iwata, H., Miyauchi, K., Daida, H., Suwa, S., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02633-5 · Cited by 25
Makam, R. C. P., Erskine, N. A. K., McManus, D. D., Lessard, D., Gore, J. M., Yarzebski, J., & Goldberg, R. J. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.08.065 · Cited by 25
The Effect of July Admission in the Process of Care of Patients with Acute Cardiovascular Conditions
Garcia, S. A., Canoniero, M. J., & Young, L. (2009) · Southern Medical Journal · doi:10.1097/smj.0b013e3181a2f8ca · Cited by 25
Pepine, C. J. (2010) · Annals of Medicine · doi:10.3109/07853890903260898 · Cited by 25
Moschovitis, A., Simon, R., Seidenstücker, A., Klauß, V., Baylacher, M., Lüscher, T. F., Moccetti, T., Windecker, S., Meier, B., & Hess, O. M. (2010) · EuroIntervention · doi:10.4244/eijv6i1a10 · Cited by 26
Robinson, J. G., Davidson, M. H., Shah, A. K., Lin, J., Neff, D., DeLucca, P. T., Tomassini, J. E., Veltri, E. P., & Tershakovec, A. M. (2007) · Aging Health · doi:10.2217/1745509x.3.6.691 · Cited by 25
Frota, K. D. M. G., Matias, A. C. G., & Arêas, J. A. G. (2010) · Food Science and Technology · doi:10.1590/s0101-20612010000500002 · Cited by 25
O'Brien, E. C., Wu, J., Schulte, P. J., Christian, A., Laskey, W. K., Bhatt, D. L., Peterson, E. D., Hernandez, A. F., & Fonarow, G. C. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.11.014 · Cited by 24
Brown, R., Welsh, P. I., & Logue, J. (2020) · Open Heart · doi:10.1136/openhrt-2020-001396 · Cited by 24
The Unhidden Cost of Noncompliance
Mahoney, J. J., Ansell, B. J., Fleming, W. K., & Butterworth, S. W. (2008) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2008.14.s6-b.1 · Cited by 24
Rodríguez, F., Olufade, T. O., Heithoff, K. A., Friedman, H. S., Navaratnam, P., & Foody, J. M. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.10.021 · Cited by 23
Agouridis, A. P., Tsimihodimos, V., Filippatos, T. D., Tselepis, A. D., & Elisaf, M. (2011) · Lipids · doi:10.1007/s11745-011-3538-0 · Cited by 23
Statins in acute coronary syndrome: very early initiation and benefits
Angeli, F., Reboldi, G., Mazzotta, G., Garofoli, M., Cerasa, M. F., & Verdecchia, P. (2012) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944712452463 · Cited by 23
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Scarpioni, R., Ricardi, M., Melfa, L., & Cristinelli, L. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00182.x · Cited by 24
Mansi, I. A., Mortensen, E. M., Pugh, M. J., Wegner, M., & Frei, C. R. (2012) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31825b8edf · Cited by 22
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Kahn, M. R., Kosmas, C. E., Wagman, G., Serrao, G. W., Fallahi, A., Grady, K. M., & Vittorio, T. J. (2012) · Congestive Heart Failure · doi:10.1111/chf.12006 · Cited by 21
Kitkungvan, D., Fillipon, N. M. L., Dani, S. S., & Downey, B. C. (2010) · Journal of clinical lipidology · doi:10.1016/j.jacl.2010.06.003 · Cited by 21
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Béliard, S., Bonnet, F., Bouhanick, B., Bruckert, É., Cariou, B., Charrière, S., Durlach, V., Moulin, P., Valéro, R., & Vergès, B. L. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.07.033 · Cited by 21
Blazing, M. A., Giugliano, R. P., de Lemos, J. A., Cannon, C. P., Tonkin, A. M., Ballantyne, C. M., Lewis, B. S., Musliner, T. A., Tershakovec, A. M., Lokhnygina, Y. V., et al. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.09.004 · Cited by 21
Self-citationWawruch, M., Zatko, D., Wimmer, G., Luha, J., Hricak, V., Murín, J., Kukumberg, P., Tesař, T., Hloska, A., & Shah, R. R. (2016) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4148 · Cited by 21
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Candrilli, S. D., Manjunath, R., Davis, K. L., & Gidal, B. E. (2010) · Epilepsy Research · doi:10.1016/j.eplepsyres.2010.07.021 · Cited by 21
Metadata
- Authors
- Cannon, C. P., Steinberg, B. A., Murphy, S. A., Mega, J. L., & Braunwald, E.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Cannon, Christopher P.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 48
- Issue
- 3
- Pages
- 438-445
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2040462758
- Cited by
- 770
- References
- 27
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 20 · 2023: 24 · 2022: 22 · 2021: 23 · 2020: 36 · 2019: 26 · 2018: 30 · 2017: 36 · 2016: 35 · 2015: 28 · 2014: 43 · 2013: 46 · 2012: 48
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- high-intensity statin therapy, intensive lipid lowering, statin therapy, cardiovascular outcomes, coronary artery disease, acute coronary syndrome, myocardial infarction, coronary death, cardiovascular mortality, TNT trial, IDEAL trial, PROVE IT-TIMI 22, pravastatin, atorvastatin
- MeSH terms
- Cardiovascular Diseases, Coronary Disease, Dose-Response Relationship, Drug, Humans, Syndrome, Randomized Controlled Trials as Topic, Treatment Outcome, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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