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Cited by 192Cardiovascular Effects of ExerciseCardiomyopathy and Myosin StudiesCardiac Arrhythmias and Treatments

Magnetic Resonance Imaging of Arrhythmogenic Right Ventricular Dysplasia

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Tandri, Harikrishna, Castillo, Ernesto, Ferrari, Victor A., Nasir, Khurram, Dalal, Darshan, Bomma, Chandra, Calkins, Hugh, Bluemke, David A.·2006·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2006.07.051
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Abstract

Objectives The purpose of this study was to determine interobserver agreement for interpretation of magnetic resonance imaging (MRI) examinations of arrhythmogenic right ventricular dysplasia (ARVD) and to determine sensitivity and specificity of fat detection versus functional parameters measured by MRI.Background The interobserver variability of MRI and the relative importance of different MRI parameters (fat detection, regional and global right ventricular [RV] function) for ARVD diagnosis is unknown.Methods Two experienced observers blinded to the clinical history independently analyzed MRI datasets obtained from 40 patients evaluated for ARVD. Twenty normal subjects underwent MRI and served as control subjects. The MRI scans were performed according to a standard protocol on a 1.5-T scanner. The observers reported on fat infiltration, global and regional RV function, myocardial thinning, and chamber dilatation qualitatively. The RV volumes were measured on the cine sequences.Results Interobserver kappa scores for fat infiltration, global and regional RV function, wall thinning, and RV outflow dilatation were 0.74, 0.94, 0.89, 0.93, and 0.93, respectively. Correlation coefficients between observers for RV end-diastolic volume, end-systolic volume, and ejection fraction were 0.93, 0.94, and 0.95, respectively (p < 0.001). Fifteen patients were diagnosed with ARVD using Task Force criteria. Sensitivity of fat infiltration, RV enlargement, and regional RV dysfunction for diagnosing ARVD was 84%, 68%, and 78%, and specificity was 79%, 96%, and 94%, respectively.Conclusions Qualitative assessment of RV structure and function is highly reproducible for experienced observers. Among the qualitative parameters, fat infiltration is less reproducible and lacks specificity compared with RV kinetic abnormalities.

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  • Epicardial fat anterior to the right ventricle is extremely common, and epicardial fat commonly interpolates into the RV free wall.

    “However, widespread use of cardiac MRI and computed tomography, particularly when evaluating for possible arrhythmogenic right ventricular dysplasia, have revealed that epicardial fat anterior to the right ventricle is extremely common (178, 342, 344). Moreover, epicardial fat commonly interpolates into the RV free wall.”

    From Cardiac remodeling in obesity (2008) · cites this paper as [342]

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  1. [10]10. Pennell D.: Cardiovascular magnetic resonance. Heart 2001; 85: 581. Crossref PubMed Google Scholar

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Authors
Tandri, H., Castillo, E., Ferrari, V. A., Nasir, K., Dalal, D., Bomma, C., Calkins, H., & Bluemke, D. A.
Affiliations
  • Johns Hopkins University (US)
  • University of Pennsylvania (US)
Corresponding author
Bluemke, David A.
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2006-12
Volume
48
Issue
11
Pages
2277-2284
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2006.07.051
OpenAlex
W164944859
Cited by
192
References
24
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 9 · 2018: 3 · 2017: 10 · 2016: 7 · 2015: 13 · 2014: 14 · 2013: 13 · 2012: 9
FWCI
12.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (U01HL065594, 1 UO1 HL65594-01A1)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords
arrhythmogenic right ventricular cardiomyopathy, interobserver agreement, right ventricular function, right ventricular ejection fraction, right ventricular volume, sensitivity and specificity, Task Force Criteria
MeSH terms
Adipose Tissue, Adolescent, Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Sensitivity and Specificity, Observer Variation, Ventricular Function, Right, Arrhythmogenic Right Ventricular Dysplasia

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