The DOI matches its Crossref record, with a small difference in title or year; 67 of the 67 references it cites were found in a registry or an index.
Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death
Open accessAbstract
Objectives The purpose of this research was to assess the association between the metabolic syndrome (MetSyn) and cardiovascular events and mortality by meta-analyses of longitudinal studies.Background Controversy exists regarding the cardiovascular risk associated with MetSyn.Methods We searched electronic reference databases through March 2005, studies that referenced Reaven's seminal article, abstracts presented at meetings in 2003 to 2004, and queried experts. Two reviewers independently assessed eligibility. Longitudinal studies reporting associations between MetSyn and cardiovascular events or mortality were eligible. Two reviewers independently used a standardized form to collect data from published reports. Authors were contacted. Study quality was assessed by the control of selection, detection, and attrition biases.Results We found 37 eligible studies that included 43 cohorts (inception 1971 to 1997) and 172,573 individuals. Random effects meta-analyses showed MetSyn had a relative risk (RR) of cardiovascular events and death of 1.78 (95% confidence interval [CI] 1.58 to 2.00). The association was stronger in women (RR 2.63 vs. 1.98, p = 0.09), in studies enrolling lower risk (<10%) individuals (RR 1.96 vs. 1.43, p = 0.04), and in studies using factor analysis or the World Health Organization definition (RR 2.68 and 2.06 vs. 1.67 for National Cholesterol Education Program definition and 1.35 for other definitions; p = 0.005). The association remained after adjusting for traditional cardiovascular risk factors (RR 1.54, 95% CI 1.32 to 1.79).Conclusions The best available evidence suggests that people with MetSyn are at increased risk of cardiovascular events. These results can help clinicians counsel patients to consider lifestyle interventions, and should fuel research of other preventive interventions.
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“It is imperative to recognize that MetS is not just a repackaging of its individual risk components, but, as demonstrated in at least 1 analysis, is a clinical entity associated with an increased risk of ASCVD or death, even after controlling for its component risk factors (risk ratio: 1.54; 95% confidence interval: 1.32 to 1.79) (39).”
From The CardioMetabolic Health Alliance (2015) · cites this paper as [39]
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Metadata
- Authors
- Gami, A. S., Witt, B. J., Howard, D. E., Erwin, P. J., Gami, L. A., Somers, V. K., & Montori, V. M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Gami, Apoor S.
- ORCID
- Somers, Virend K.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 49
- Issue
- 4
- Pages
- 403-414
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W74340591
- Cited by
- 1,888
- References
- 67
- Citations by year
- 2026: 31 · 2025: 38 · 2024: 70 · 2023: 58 · 2022: 76 · 2021: 91 · 2020: 87 · 2019: 99 · 2018: 103 · 2017: 84 · 2016: 113 · 2015: 125 · 2014: 131 · 2013: 140 · 2012: 122
- FWCI
- 91.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- metabolic syndrome, cardiovascular events, cardiovascular mortality, cardiovascular risk, sex differences, metabolic syndrome definitions, traditional cardiovascular risk factors, lifestyle intervention
- MeSH terms
- Cardiovascular Diseases, Humans, Longitudinal Studies, Risk Factors, Metabolic Syndrome
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