The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Measures of Obesity and Cardiovascular Risk Among Men and Women
Open accessAbstract
Objectives We examined associations between anthropometric measures (body mass index [BMI], waist circumference [WC], waist-to-hip ratio [WHR], waist-to-height ratio [WHtR]) and risk of incident cardiovascular disease (CVD, including nonfatal myocardial infarction, nonfatal ischemic stroke, cardiovascular death). Background Controversy exists regarding the optimal approach to measure adiposity, and the utility of BMI has been questioned. Methods Participants included 16,332 men in the Physicians’ Health Study (mean age 61, 1991) and 32,700 women in the Women’s Health Study (mean age 61, 1999). We used Cox proportional hazards models to determine relative risks (RR) and 95% confidence intervals (CI) for developing CVD according to self-reported anthropometric indices. Results A total of 1505 CVD cases occurred in men, and 414 occurred in women (median follow-up, 14.2 and 5.5 years, respectively). While WHtR demonstrated statistically the strongest associations with CVD and best model fit, CVD risk increased linearly and significantly with higher levels of all indices. Adjusting for confounders, the RR (CI) for CVD was 0.58 (0.32–1.05) for men with the lowest WHtR (<0.45) and 2.36 (1.61–3.47) for the highest WHtR (≥0.69; versus WHtR 0.49-<0.53). Among women, the RR (95% CI) was 0.65 (0.33– 1.31) for those with the lowest WHtR (<0.42) and 2.33 (1.66–3.28) for the highest WHtR (≥0.68; versus WHtR 0.47- <0.52). Conclusions WHtR demonstrated statistically the best model fit and strongest associations with CVD. However, as compared to BMI, differences in cardiovascular risk assessment using other indices were small and likely not clinically consequential. Our findings emphasize that higher levels of adiposity, however measured, confer increased risk of CVD.
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Self-citationLee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137
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Self-citationTest of the National Death Index and Equifax Nationwide Death Search
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Cited by
Obesity and Cardiovascular Disease
Lavie, C. J., Milani, R. V., & Ventura, H. O. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.068 · Cited by 2,326
Ashwell, M., Gunn, P., & Gibson, S. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00952.x · Cited by 2,130
Browning, L. M., Hsieh, S. D., & Ashwell, M. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000144 · Cited by 1,400
Assessing Adiposity: A Scientific Statement From the American Heart Association
Cornier, M.-A., Després, J.-P., Davis, N., Grossniklaus, D. A., Klein, S., Lamarche, B., Lopez-Jimenez, F., Rao, G., St-Onge, M.-P., Towfighi, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318233bc6a · Cited by 945
Neeland, I. J., Ayers, C. R., Rohatgi, A. K., Turer, A. T., Berry, J. D., Das, S. R., Vega, G. L., Khera, A., McGuire, D. K., Grundy, S. M., et al. (2013) · Obesity · doi:10.1002/oby.20135 · Cited by 497
Metadata
- Authors
- Gelber, R. P., Gaziano, J. M., Orav, E. J., Manson, J. E., Buring, J. E., & Kurth, T.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 52
- Issue
- 8
- Pages
- 605-615
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2015453495
- Cited by
- 357
- References
- 9
- FWCI
- 23.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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