The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Does Microvolt T-Wave Alternans Testing Predict Ventricular Tachyarrhythmias in Patients With Ischemic Cardiomyopathy and Prophylactic Defibrillators?
Open accessAbstract
Objectives The purpose of this trial was to determine whether microvolt T-wave alternans (MTWA) predicts ventricular tachyarrhythmic events (VTEs) in post-myocardial infarction patients with left ventricular ejection fraction (LVEF) < or =30%.Background Previous studies have established MTWA as a predictor for total and arrhythmic mortality, but its ability to identify prophylactic implantable cardioverter-defibrillator (ICD) recipients most likely to experience VTEs remains uncertain.Methods This prospective trial was conducted at 50 U.S. centers. Patients were eligible if they met MADIT-II (Multicenter Automatic Defibrillator Implantation Trial II) indications for device implant. All patients underwent MTWA testing followed by ICD implantation, with pre-specified programming to minimize the likelihood of therapies for non-life-threatening VTE. Minimum follow-up was 2 years with annual MTWA testing. Initially indeterminate MTWA tests were repeated.Results Analyses were conducted on 575 patients (84% male; average age +/- SD = 65 +/- 11 years; average LVEF +/- SD = 0.24 +/- 0.05). The final distribution of MTWA results were: MTWA positive in 293 (51%), MTWA negative in 214 (37%), and indeterminate in 68 patients (12%). Over an average follow-up of 2.1 +/- 0.9 years, there were 70 VTEs. A VTE occurred in 48 of 361 (13%, 6.3%/year) MTWA non-negative and 22 of 214 (10%, 5.0%/year) MTWA negative patients. A non-negative MTWA test result was not associated with VTE (hazard ratio: 1.26; 95% confidence interval: 0.76 to 2.09; p = 0.37), although total mortality was significantly increased (hazard ratio: 2.04; 95% confidence interval: 1.10 to 3.78; p = 0.02).Conclusions In MADIT-II-indicated ICD-treated patients, the risk of VTE does not differ according to MTWA classification, despite differences in total mortality. (MASTER I-Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients; NCT00305240).
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“Microvolt T-wave alternans (MTWA) classification did not predict the risk of ventricular tachyarrhythmic events in ICD treated patients, although total mortality was significantly increased if MTWA was positive.20”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [20]
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Self-citationAmiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure
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1 of the 30 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Gold, 2006, T-wave alternans SCD HeFT study: primary endpoint analysis, Circulation, 114, II428
- Costantini, 2006, The Alternans Before Cardioverter Defibrillator (ABCD) Trial: a noninvasive strategy for primary prevention of sudden cardiac death using T-wave alternans, Circulation, 114, 2426
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The Prognostic Power of the Clinical Exercise Test
Leino, J. (2011) · Tampere University Institutional Repository (Tampere University)
Metadata
- Authors
- Chow, T., Kereiakes, D. J., Onufer, J., Woelfel, A., Gursoy, S., Peterson, B. J., Brown, M. L., Pu, W., & Benditt, D. G.
- Affiliations
- Christ Hospital (US)
- Medtronic (United States) (US)
- University of Minnesota (US)
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 52
- Issue
- 20
- Pages
- 1607-1615
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W84927980
- Cited by
- 201
- References
- 30
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 12 · 2014: 11 · 2013: 21 · 2012: 23
- FWCI
- 18.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medtronic
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- microvolt T-wave alternans, ventricular tachyarrhythmia, ischemic cardiomyopathy, implantable cardioverter-defibrillator, MADIT II, myocardial infarction, left ventricular ejection fraction, arrhythmia risk prediction, all-cause mortality
- MeSH terms
- Aged, Female, Heart Function Tests, Humans, Male, Middle Aged, Cardiomyopathies, Prospective Studies, Defibrillators, Implantable, Tachycardia, Ventricular, Myocardial Ischemia
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