Acute heart failure syndromes

Gheorghiade, Mihai; Pang, Peter S.

doi:10.1016/j.jacc.2008.10.041

Cited by 600Heart Failure Treatment and ManagementCardiovascular Function and Risk FactorsCardiac Fibrosis and Remodeling

Acute heart failure syndromes

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Gheorghiade, Mihai, Pang, Peter S.·2009·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2008.10.041

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Abstract

Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes.

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A significant number of patients hospitalized for HFrEF have worsening hemodynamics and/or worsening renal function, which might lead to reluctance with initiating or continuing hemodynamically active therapies.
“Nevertheless, a significant number of patients hospitalized for HFrEF have worsening hemodynamics and/or worsening renal function, which might lead to reluctance with initiating or continuing hemodynamically active therapies.14-16”
From CCS/CHFS Heart Failure Guidelines Update: Defining a New Pharmacologic Standard of Care for Heart Failure With Reduced Ejection Fraction (2021) · cites this paper as [14]
The Prognostic Factors section reports worsening renal function during hospitalization in approximately 30% of patients with acute heart failure syndromes (AHFS). The Clinical Trials section describes worsening hemodynamics in the weeks after discharge, not during hospitalization. The paper does not establish these findings specifically for HFrEF or say that they cause reluctance to initiate or continue hemodynamically active therapies. Page numbers were not available for these passages. (LLM, conf=0.86)
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Authors: Gheorghiade, M., & Pang, P. S.
Affiliations: Northwestern University (US)
Corresponding author: Gheorghiade, Mihai
ORCID: Gheorghiade, Mihai
Pang, Peter S.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2009-02
Volume: 53
Issue: 7
Pages: 557-573
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2008.10.041
OpenAlex: W2050481558
Cited by: 600
References: 180
Citations by year: 2026: 11 · 2025: 14 · 2024: 22 · 2023: 23 · 2022: 22 · 2021: 30 · 2020: 20 · 2019: 24 · 2018: 26 · 2017: 47 · 2016: 35 · 2015: 48 · 2014: 45 · 2013: 53 · 2012: 42
FWCI: 8.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1626 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: acute heart failure, hospitalization, post-discharge outcomes, hospital readmission, mortality, renal dysfunction, prognosis, clinical trial design, pathophysiology
MeSH terms: Acute Disease, Heart Failure, Humans, Patient Readmission, Treatment Outcome, Health Care Costs

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