Effect of Intensive Statin Therapy on Regression of Coronary Atherosclerosis in Patients With Acute Coronary Syndrome
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Objectives The objective of this study was to evaluate whether the regressive effects of aggressive lipid-lowering therapy with atorvastatin on coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) are generalized for other statins in multicenter setting.Background A previous single-center study reported beneficial regressive effects of atorvastatin in patients with ACS on PV of the nonculprit site by intravascular ultrasound (IVUS) evaluation. The effect of statins other than atorvastatin on PV has not been evaluated in the setting of ACS.Methods The JAPAN-ACS (Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome) study was a prospective, randomized, open-label, parallel group study with blind end point evaluation conducted at 33 centers in Japan. A total of 307 patients with ACS undergoing IVUS-guided percutaneous coronary intervention were randomized, and 252 patients had evaluable IVUS examinations at baseline and 8 to 12 months' follow-up. Patients were randomly assigned to receive either 4 mg/day of pitavastatin or 20 mg/day of atorvastatin. The primary end point was the percentage change in nonculprit coronary PV.Results The mean percentage change in PV was -16.9 +/- 13.9% and -18.1 +/- 14.2% (p = 0.5) in the pitavastatin and atorvastatin groups, respectively, which was associated with negative vessel remodeling. The upper limit of 95% confidence interval of the mean difference in percentage change in PV between the 2 groups (1.11%, 95% confidence interval: -2.27 to 4.48) did not exceed the pre-defined noninferiority margin of 5%.Conclusions The administration of pitavastatin or atorvastatin in patients with ACS equivalently resulted in significant regression of coronary PV (Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome; NCT00242944).
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The rate of change in plaque (atheroma) volume correlates significantly with cardiovascular event risk.
“The results of one metaanalysis revealed that the rate of change in plaque (atheroma) volume [percent atheroma volume (PAV)] correlates significantly with cardiovascular event risk641).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [641]
Cites
OLSSON, A. G., McMurray, J. J. V., Thorgeirsson, G., Spaulding, C. M., Slattery, J., Pyörälà, K., Færgeman, O., Wright, R. S., Berg, K. M., Wilhelmsen, L., et al. (1994) · The Lancet · Cited by 8,467 · see citing works
Sacks, F. M., Pfeffer, M. A., Moye, L. A., Rouleau, J. L., Rutherford, J. D., Cole, T. G., Brown, L., Warnica, J. W., Arnold, J. M. O., Wun, C.-C., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351401 · Cited by 7,439 · see citing works
(1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391902 · Cited by 5,261 · see citing works
Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes
Cannon, C. P., Braunwald, E., McCabe, C. H., Rader, D. J., Rouleau, J. L., Belder, R., Joyal, S. V., Hill, K. A., Pfeffer, M. A., & Skene, A. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040583 · Cited by 4,938 · see citing works
Falk, E., Shah, P. K., & Fuster, V. (1995) · Circulation · doi:10.1161/01.cir.92.3.657 · Cited by 3,536 · see citing works
Pedersen, T. R. (2004) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2004.08.027 · Cited by 3,104 · see citing works
Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Brown, B. G., Ganz, P., Vogel, R. A., Crowe, T., Howard, G., Cooper, C. J., Brodie, B. R., et al. (2004) · JAMA · doi:10.1001/jama.291.9.1071 · Cited by 2,358 · see citing works
Mintz, G. S., Nissen, S. E., Anderson, W. D., Bailey, S. R., Erbel, R. M., Fitzgerald, P. J., Pinto, F. J., Rosenfield, K., Siegel, R. J., Tuzcu, E. M., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01175-5 · Cited by 2,186 · see citing works
Nissen, S. E., Nicholls, S. J., Sipahi, I., Libby, P., Raichlen, J. S., Ballantyne, C. M., Davignon, J., Erbel, R., Fruchart, J. C., Tardif, J.-C., et al. (2006) · JAMA · doi:10.1001/jama.295.13.jpc60002 · Cited by 2,047 · see citing works
Coronary Risk Factors and Plaque Morphology in Men with Coronary Disease Who Died Suddenly
BURKE, A. P., Farb, A. A., Malcom, G. T., Liang, Y.-H., Smialek, J. E., & Virmani, R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705013361802 · Cited by 1,739 · see citing works
Tuomilehto, J., Vidgrén, G., Toivanen, L., Tuomilehto-Wolf, E., Kohtamäki, K., Stengård, J., Zimmet, P., Mackay, I., Rowley, M., & Koskela, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92521-6 · Cited by 1,658 · see citing works
Extent and Direction of Arterial Remodeling in Stable Versus Unstable Coronary Syndromes
Schoenhagen, P., Ziada, K. M., Kapadia, S. R., Crowe, T. D., Nissen, S. E., & Tuzcu, E. M. (2000) · Circulation · doi:10.1161/01.cir.101.6.598 · Cited by 750 · see citing works
Wallentin, L. C., Lagerqvist, B., Husted, S., Kontny, F. P., Ståhle, E., & Swahn, E. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02427-2 · Cited by 674 · see citing works
Early Statin Treatment in Patients With Acute Coronary Syndrome
Okazaki, S., Yokoyama, T., Miyauchi, K., Shimada, K., Kurata, T., Sato, H., & Daida, H. (2004) · Circulation · doi:10.1161/01.cir.0000140261.58966.a4 · Cited by 553 · see citing works
Self-citationAsakura, M., Ueda, Y., Yamaguchi, O., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01135-4 · Cited by 386 · see citing works
Testing Statistical Hypotheses of Equivalence
Wellek, S. (2002) · Chapman & Hall/CRC eBooks · doi:10.1201/9781420035964 · Cited by 323 · see citing works
Brown, G. C. (2004) · Evidence-Based Eye Care · doi:10.1097/01.ieb.0000142773.91809.e5 · Cited by 165 · see citing works
Early Statin Initiation and Outcomes in Patients With Acute Coronary Syndromes
Newby, L. K. (2002) · JAMA · doi:10.1001/jama.287.23.3087 · Cited by 155 · see citing works
Pitavastatin: efficacy and safety in intensive lipid lowering
Hayashi, T., Yokote, K., Saito, Y., & Iguchi, A. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.14.2315 · Cited by 62 · see citing works
Testing statistical hypotheses of equivalence
(2003) · Choice Reviews Online · doi:10.5860/choice.40-5854 · Cited by 62 · see citing works
Chemarin-Alibelli, M.-J., Pieraggi, M. T., Elbaz, M., et al. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89361-7 · Cited by 58 · see citing works
Schoenhagen, P., Sapp, S. K., Tuzcu, E. M., Magyar, W. A., Popovich, J., Boumitri, M., Vince, D. G., Crowe, T., & Nissen, S. E. (2003) · Journal of the American Society of Echocardiography · doi:10.1067/mje.2003.45 · Cited by 53 · see citing works
Takashima, H., Ozaki, Y., Yasukawa, T., Waseda, K., Asai, K., Wakita, Y., Kuroda, Y., Kosaka, T., Kuhara, Y., & Ito, T. (2007) · Circulation Journal · doi:10.1253/circj.71.1678 · Cited by 39 · see citing works
Self-citationMiyauchi, K., Kimura, T., Morimoto, T., Nakagawa, Y., Yamagishi, M., Ozaki, Y., Hiro, T., Daida, H., & Matsuzaki, M. (2006) · Circulation Journal · doi:10.1253/circj.70.1624 · Cited by 35 · see citing works
Self-citationFranzen, D., Sechtem, U., & Höpp, H. W. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00616-x · Cited by 30 · see citing works
Clinical relevance of statins: instituting treatment early in acute coronary syndrome patients
Thompson, P. L. (2001) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(00)00005-2 · Cited by 16 · see citing works
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Oesterle, A., Laufs, U., & Liao, J. K. (2017) · Circulation Research · doi:10.1161/circresaha.116.308537 · Cited by 1,247 · see citing works
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Self-citationTsujita, K., Sugiyama, S., Sumida, H., Shimomura, H., Yamashita, T., Yamanaga, K., Komura, N., Sakamoto, K., Oka, H., Nakao, K., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.05.065 · Cited by 459 · see citing works
Watanabe, T., Ando, K., Daidoji, H., Otaki, Y., Sugawara, S., Matsui, M., Ikeno, E., Hirono, O., Miyawaki, H., Yashiro, Y., et al. (2017) · Journal of Cardiology · doi:10.1016/j.jjcc.2017.07.007 · Cited by 177 · see citing works
Hagiwara, N., Kawada-Watanabe, E., Koyanagi, R., Arashi, H., Yamaguchi, J., Nakao, K., Tobaru, T., Tanaka, H., Oka, T., Endoh, Y., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx162 · Cited by 136 · see citing works
Hiro, T., Kimura, T., Morimoto, T., Miyauchi, K., Nakagawa, Y., Yamagishi, M., Ozaki, Y., Kimura, K., Saito, S., Yamaguchi, T., et al. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0766 · Cited by 94 · see citing works
Self-citationLaufs, U., Karmann, B., & Pittrow, D. (2016) · Clinical Research in Cardiology · doi:10.1007/s00392-016-0991-z · Cited by 59 · see citing works
Natsuaki, M., Furukawa, Y., Morimoto, T., Nakagawa, Y., Ono, K., Kaburagi, S., Inada, T., Mitsuoka, H., Taniguchi, R., Nakano, A., et al. (2012) · Circulation Journal · doi:10.1253/circj.cj-11-1356 · Cited by 49 · see citing works
Self-citationNakajima, N., Miyauchi, K., Yokoyama, T., Ogita, M., Miyazaki, T., Tamura, H., Nishino, A., Yokoyama, K., Okazaki, S., Kurata, T., et al. (2014) · IJC Metabolic & Endocrine · doi:10.1016/j.ijcme.2014.03.001 · Cited by 37 · see citing works
Self-citationIto, T., Fujita, H., Tani, T., & Ohte, N. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.026 · Cited by 30 · see citing works
Tang, X., Yang, Y., Luo, S., Zhao, Y., Lu, C., Luo, Y., Zhang, F., & Xiao, H. (2016) · Coronary Artery Disease · doi:10.1097/mca.0000000000000403 · Cited by 20 · see citing works
- Authors
- Hiro, T., Kimura, T., Morimoto, T., Miyauchi, K., Nakagawa, Y., Yamagishi, M., Ozaki, Y., Kimura, K., Saito, S., Yamaguchi, T., Daida, H., & Matsuzaki, M.
- Affiliations
- Yamaguchi University (JP)
- Kyoto University (JP)
- Juntendo University (JP)
- Tenri Hospital (JP)
- Kanazawa University (JP)
- Fujita Health University (JP)
- Yokohama City University Medical Center (JP)
- Nihon University (JP)
- Toranomon Hospital (JP)
- Corresponding author
- Matsuzaki, Masunori
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 54
- Issue
- 4
- Pages
- 293-302
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W110324665
- Cited by
- 358
- References
- 27
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 15 · 2021: 22 · 2020: 12 · 2019: 10 · 2018: 19 · 2017: 24 · 2016: 17 · 2015: 20 · 2014: 23 · 2013: 28 · 2012: 42
- FWCI
- 42.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- acute coronary syndrome, statin therapy, atorvastatin, pitavastatin, coronary plaque volume, plaque regression, intravascular ultrasound, percutaneous coronary intervention, lipid-lowering therapy, vascular remodeling, non-inferiority
- MeSH terms
- Atorvastatin, Aged, Coronary Artery Disease, Coronary Vessels, Female, Heptanoic Acids, Humans, Male, Middle Aged, Pyrroles, Quinolines, Treatment Outcome, Ultrasonography, Interventional, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Acute Coronary Syndrome
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