The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Noninvasive Quantification and Optimization of Acute Cell Retention by In Vivo Positron Emission Tomography After Intramyocardial Cardiac-Derived Stem Cell Delivery
Open accessAbstract
Objectives To quantify acute myocardial retention of cardiac-derived stem cells (CDCs) and evaluate different delivery methods using Positron Emission Tomography (PET). Background Success of stem cell transplantation for cardiac regeneration is partially limited by low retention/engraftment of the delivered cells. A clinically applicable method for accurate quantification of cell retention would enable optimization of cell delivery. Methods CDCs derived from syngeneic, male Wistar Kyoto (WK) rats were labeled with 18FDG and injected intramyocardially into the ischemic region of female WK rats following permanent left coronary artery ligation. The effects of fibrin glue, bradycardia (adenosine) and cardiac arrest were examined. 18FDG PET was performed for quantification of cell retention. Quantitative PCR for the male-specific SRY gene was performed to validate the PET results. Results Myocardial retention of cells suspended in PBS 1 hr after delivery was 17.6±11.5% by PCR and 17.8±7.3% by PET. When CDCs were injected immediately following induction of cardiac arrest, retention was increased to 75.6±18.6%. Adenosine slowed the ventricular rate and doubled CDC retention (35.4±5.3%). A similar increase in CDC retention was observed following epicardial application of fibrin glue at the injection site (37.5±8.2%). PCR revealed a significant increase in 3 week cell engraftment in the fibrin glue animals (22.1±18.6% vs 5.3±3.1%, for fibrin glue and PBS respectively). Conclusions In vivo PET permits accurate measurement of CDC retention early after intramyocardial delivery. Sealing injection sites with fibrin glue or lowering ventricular rate by adenosine may be clinically translatable methods for improving stem cell engraftment in a beating heart.
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Isolation and Expansion of Adult Cardiac Stem Cells From Human and Murine Heart
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Stem-cell therapy for cardiac disease
Segers, V. F. M., & Lee, R. T. (2008) · Nature · doi:10.1038/nature06800 · Cited by 1,179
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Self-citationAMIDE: A Free Software Tool for Multimodality Medical Image Analysis
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Fibrin: A versatile scaffold for tissue engineering applications
Ahmed, T. A. E., Dare, E. V., & Hincke, M. (2008) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2007.0435 · Cited by 994
Monitoring of Bone Marrow Cell Homing Into the Infarcted Human Myocardium
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Dynamic Imaging of Allogeneic Mesenchymal Stem Cells Trafficking to Myocardial Infarction
Kraitchman, D. L., Tatsumi, M., Gilson, W. D., Ishimori, T., Kedziorek, D., Walczak, P., Segars, W. P., H. Chen, H., Fritzges, D., Izbudak, I., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.537480 · Cited by 602
Self-citationAicher, A., Brenner, W., Zuhayra, M., Badorff, C., Massoudi, S., Assmus, B., Eckey, T., Henze, E., Zeiher, A. M., & Dimmeler, S. (2003) · Circulation · doi:10.1161/01.cir.0000062649.63838.c9 · Cited by 559
Christman, K. L., Vardanian, A. J., Fang, Q., Sievers, R. E., Fok, H. H., & Lee, R. J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.04.040 · Cited by 545
Cited by
Gaetani, R., Feyen, D. A. M., Verhage, V., Slaats, R., Messina, E., Christman, K. L., Giacomello, A., Doevendans, P. A. F. M., & Sluijter, J. P. G. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.05.005 · Cited by 307
Sekine, H., Shimizu, T., Dobashi, I., Matsuura, K., Hagiwara, N., Takahashi, M., Kobayashi, E., Yamato, M., & Okano, T. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0659 · Cited by 276
Imaging challenges in biomaterials and tissue engineering
Appel, A. A., Anastasio, M. A., Larson, J. C., & Brey, E. M. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.033 · Cited by 273
Metadata
- Authors
- Terrovitis, J., Lautamäki, R., Bonios, M., Fox, J., Engles, J. M., Yu, J., Leppo, M. K., Pomper, M. G., Wahl, R. L., Seidel, J., Tsui, B. M., Bengel, F. M., Abraham, M. R., & Marbán, E.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 54
- Issue
- 17
- Pages
- 1619-1626
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1980917009
- Cited by
- 268
- References
- 31
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Terrovitis, J., Lautamäki, R., Bonios, M., Fox, J., Engles, J. M., Yu, J., Leppo, M. K., Pomper, M. G., Wahl, R. L., Seidel, J., Tsui, B. M., Bengel, F. M., Abraham, M. R., & Marbán, E. (2009). Noninvasive Quantification and Optimization of Acute Cell Retention by In Vivo Positron Emission Tomography After Intramyocardial Cardiac-Derived Stem Cell Delivery. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2009.04.097
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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