The DOI matches its Crossref record; 87 of the 88 references it cites were found in a registry or an index.
Use of Herbal Products and Potential Interactions in Patients With Cardiovascular Diseases
Open accessAbstract
More than 15 million people in the U.S. consume herbal remedies or high-dose vitamins. The number of visits to providers of complementary and alternative medicine exceeds those to primary care physicians, for annual out-of-pocket costs of $30 billion. Use of herbal products forms the bulk of treatments, particularly by elderly people who also consume multiple prescription medications for comorbid conditions, which increases the risk of adverse herb-drug-disease interactions. Despite the paucity of scientific evidence supporting the safety or efficacy of herbal products, their widespread promotion in the popular media and the unsubstantiated health care claims about their efficacy drive consumer demand. In this review, we highlight commonly used herbs and their interactions with cardiovascular drugs. We also discuss health-related issues of herbal products and suggest ways to improve their safety to better protect the public from untoward effects.
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“Interactions between foods or dietary supplements and drugs are an underappreciated source of therapeutic variability and iatrogenic risk [1,2].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [1]
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“The failure of patient–clinician communication about supplement use amplifies this risk, as physicians rarely initiate the discussion [1,3].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Unlike drug–drug interactions, those involving “natural” products are frequently omitted at history taking, because of the perception that what is natural is harmless [1,3].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [1]
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Citations
Cites
Trends in Alternative Medicine Use in the United States, 1990-1997
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Unconventional medicine in the United States-Prevalence, costs, and patterns of use
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“(1,3) ound an increased number of visits to CAM providers from 27 million to 629 million, whereas the number of visits o primary physicians remained, in essence, unchanged Fig.”
BackgroundComplementary and alternative medicine use among adults: United States, 2002
Barnes, P. M., Powell‐Griner, E., McFann, K., & Nahin, R. L. (2004) · Seminars in Integrative Medicine · doi:10.1016/j.sigm.2004.07.003 · Cited by 2,183
Urothelial Carcinoma Associated with the Use of a Chinese Herb (Aristolochia fangchi)
Nortier, J., Martinez, M.-C. M., Schmeiser, H. H., Arlt, V. M., Bieler, C. A., Pétein, M., Depierreux, M. F., Pauw, L. D., Abramowicz, D., Vereerstraeten, P., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006083422301 · Cited by 979
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UROTHELIAL CARCINOMA ASSOCIATED WITH THE USE OF A CHINESE HERB ( ARISTOLOCHIA FANGCHI )
Ortier, L. N., Arie, M., Chmeiser, H. S., Rlt, V. O. M. A., Ieler, H. A. B., Etein, M. I. P., Epierreux, M. I. F. D., Auw, L., Bramowicz, D. A. A., & Ereerstraeten, P. I. V. (2014) · Cited by 814
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Grapefruit juice–drug interactions
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Cited by
Sorted by citations
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000596 · Cited by 1,127
Izzo, A. A., Hoon‐Kim, S., Radhakrishnan, R., & Williamson, E. M. (2016) · Phytotherapy Research · doi:10.1002/ptr.5591 · Cited by 535
Drugs That May Cause or Exacerbate Heart Failure
Page, R. L., II, O’Bryant, C. L., Cheng, D., Dow, T. J., Ky, B., Stein, C. M., Spencer, A. P., Trupp, R. J., & Lindenfeld, J. M. (2016) · Circulation · doi:10.1161/cir.0000000000000426 · Cited by 495
Metadata
- Authors
- Tachjian, A., Maria, V., & Jahangir, A.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Jahangir, Arshad
- ORCID
- Jahangir, Arshad
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 55
- Issue
- 6
- Pages
- 515-525
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC2831618
- OpenAlex
- W2151268696
- Cited by
- 426
- References
- 88
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 26 · 2023: 19 · 2022: 35 · 2021: 23 · 2020: 38 · 2019: 25 · 2018: 30 · 2017: 28 · 2016: 34 · 2015: 39 · 2014: 23 · 2013: 30 · 2012: 25
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG021201, AG-21201)
- National Heart, Lung, and Blood Institute (R01HL089542, HL089542)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Health Sciences › Medicine › Nephrology › Nephrotoxicity and Medicinal Plants
- Keywords
- herbal products, complementary and alternative medicine, herb-drug interactions, cardiovascular disease, cardiovascular drugs, elderly patients, polypharmacy, herbal medicine safety
- MeSH terms
- Cardiovascular Agents, Cardiovascular Diseases, Humans, Phytotherapy, Plants, Medicinal, Treatment Outcome, Herb-Drug Interactions
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