The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Long-Term Clinical Consequences of Intense, Uninterrupted Endurance Training in Olympic Athletes
Open accessAbstract
Objectives The aim of this study was to assess incidence of cardiac events and/or left ventricular (LV) dysfunction in athletes exposed to strenuous and uninterrupted training for extended periods of time. Background Whether highly intensive and uninterrupted athletic conditioning over a long period of time might be responsible for cardiac events and/or LV dysfunction is unresolved. Methods We assessed clinical profile and cardiac dimensions and function in 114 Olympic athletes (78% male; mean age 22 +/- 4 years), free of cardiovascular disease, participating in endurance disciplines, who experienced particularly intensive and uninterrupted training for 2 to 5 consecutive Olympic Games (total, 344 Olympic events), over a 4- to 17-year-period (mean 8.6 +/- 3 years). Results Over the extended period of training and competition, no cardiac events or new diagnoses of cardiomyopathies occurred in the 114 Olympic athletes. Global LV systolic function was unchanged (ejection fraction: 62 +/- 5% to 63 +/- 5%; p = NS), and wall motion abnormalities were absent. In addition, LV volumes (142 +/- 26 ml to 144 +/- 25 ml; p = 0.52) and LV mass index (109 +/- 21 g/m(2) to 110 +/- 22 g/m(2); p = 0.74) were unchanged, and LV filling patterns remained within normal limits, although left atrial dimension showed a mild increase (37.8 +/- 3.7 mm to 38.9 +/- 3.2 mm; p < 0.001). Conclusions In young Olympic athletes, extreme and uninterrupted endurance training over long periods of time (up to 17 years) was not associated with deterioration in LV function, significant changes in LV morphology, or occurrence of cardiovascular symptoms or events.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Exercise is a powerful intervention in the prevention and treatment of cardiovascular disease for which compelling evidence exists across a wide range of exercise volumes and intensities, including among competitive athletes.4,26,37”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [4]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
Schiller, N. B., Shah, P. M., Crawford, M., DeMaria, A. N., Devereux, R. B., Feigenbaum, H., Gutgesell, H. P., Reichek, N., Sahn, D. J., Schnittger, I., et al. (1989) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(89)80014-8 · Cited by 8,110
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226
Statistical Methods in Medical Research.
Armitage, P. (1972) · Biometrics · doi:10.2307/2556182 · Cited by 5,383
Pluim, B. M., Zwinderman, A. H., van der Laarse, A., & van der Wall, E. E. (2000) · Circulation · doi:10.1161/01.cir.101.3.336 · Cited by 1,141
The Upper Limit of Physiologic Cardiac Hypertrophy in Highly Trained Elite Athletes
Pelliccia, A., Maron, B. J., Spataro, A., Proschan, M. A., & Spirito, P. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101313240504 · Cited by 1,014
Self-citationMaron, B. J., & Pelliccia, A. (2006) · Circulation · doi:10.1161/circulationaha.106.613562 · Cited by 758
Self-citationPhysiologic Left Ventricular Cavity Dilatation in Elite Athletes
Pelliccia, A., Culasso, F., Paolo, F. M. D., & Maron, B. J. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-1-199901050-00005 · Cited by 581
Self-citationScharhag, J., Schneider, G. K., Urhausen, A. J. P., Rochette, V., Kramann, B. H., & Kindermann, W. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02478-6 · Cited by 525
Neilan, T. G., Januzzi, J. L., Lee-Lewandrowski, E., Ton-Nu, T.-T., Yoerger, D. M., Jassal, D. S., Lewandrowski, K. B., Siegel, A. J., Marshall, J. E., Douglas, P. S., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.647461 · Cited by 519
Cited by
Sorted by citations
2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy
Gersh, B. J., Maron, B. J., Bonow, R. O., Dearani, J. A., Fifer, M. A., Link, M. S., Naidu, S. S., Nishimura, R. A., Ommen, S. R., Rakowski, H., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318223e2bd · Cited by 2,116
Self-citation2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy
Gersh, B. J., Maron, B. J., Bonow, R. O., Dearani, J. A., Fifer, M. A., Link, M. S., Naidu, S. S., Nishimura, R. A., Ommen, S. R., Rakowski, H., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.011 · Cited by 1,276
Self-citationGersh, B. J., Maron, B. J., Bonow, R. O., Dearani, J. A., Fifer, M. A., Link, M. S., Naidu, S. S., Nishimura, R. A., Ommen, S. R., Rakowski, H., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318223e230 · Cited by 825
Self-citationExercise-induced right ventricular dysfunction and structural remodelling in endurance athletes
La Gerche, A., Burns, A. T., Mooney, D. J., Inder, W. J., Taylor, A. J., Bogaert, J., MacIsaac, A. I., Heidbüchel, H., & Prior, D. L. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr397 · Cited by 776
Left Ventricular Structural Remodeling in Health and Disease
Gaasch, W. H., & Zile, M. R. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.07.022 · Cited by 430
Metadata
- Authors
- Pelliccia, A., Kinoshita, N., Pisicchio, C., Quattrini, F., DiPaolo, F. M., Ciardo, R., Di Giacinto, B., Guerra, E., De Blasiis, E., Casasco, M., Culasso, F., & Maron, B. J.
- Affiliations
- National Research Council (IT)
- Keio University (JP)
- Sapienza University of Rome (IT)
- Minneapolis Heart Institute Foundation (US)
- Corresponding author
- Pelliccia, Antonio
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 55
- Issue
- 15
- Pages
- 1619-1625
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2104680346
- Cited by
- 159
- References
- 32
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 13 · 2017: 3 · 2016: 8 · 2015: 22 · 2014: 15 · 2013: 5 · 2012: 17
- FWCI
- 10.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- endurance training, Olympic athletes, left ventricular dysfunction, left ventricular hypertrophy, left atrial enlargement, left ventricular ejection fraction, left ventricular mass, left ventricular filling, cardiomyopathy, cardiovascular events
- MeSH terms
- Echocardiography, Electrocardiography, Female, Follow-Up Studies, Humans, Italy, Male, Motor Activity, Cardiomyopathies, Physical Endurance, Reference Values, Risk Factors, Sports, Stroke Volume, Time Factors, Incidence, Ventricular Function, Left, Ventricular Dysfunction, Left, Young Adult, Athletes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
