The Collapse

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works

Genomewide Association Analysis of Coronary Artery Disease

Samani, N. J., Erdmann, J., Hall, A. S., Hengstenberg, C., Mangino, M., Mayer, B., Dixon, R. J., Meitinger, T., Braund, P., Wichmann, H.-E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072366 · Cited by 2,044 · see citing works

A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

Helgadottir, A., Thorleifsson, G., Manolescu, A., Gretarsdottir, S., Blondal, T., Jonasdottir, A., Jonasdottir, A., Sigurdsson, A., Baker, A., Palsson, A., et al. (2007) · Science · doi:10.1126/science.1142842 · Cited by 1,594 · see citing works

A Common Allele on Chromosome 9 Associated with Coronary Heart Disease

McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A., Roberts, R., Cox, D. R., Hinds, D. A., Pennacchio, L. A., Tybjaerg-Hansen, A., Folsom, A. R., et al. (2007) · Science · doi:10.1126/science.1142447 · Cited by 1,587 · see citing works

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

Willer, C. J., Sanna, S., Jackson, A. U., Scuteri, A., Bonnycastle, L. L., Clarke, R., Heath, S. C., Timpson, N. J., Najjar, S. S., Stringham, H. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.76 · Cited by 1,585 · see citing works

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

Shuldiner, A. R. (2009) · JAMA · doi:10.1001/jama.2009.1232 · Cited by 1,509 · see citing works

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

Myocardial Infarction Genetics Consortium (2009) · Nature Genetics · doi:10.1038/ng.327 · Cited by 1,088 · see citing works

Human genetic variation and its contribution to complex traits

Frazer, K. A., Murray, S. S., Schork, N. J., & Topol, E. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2554 · Cited by 1,073 · see citing works

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

Gudbjartsson, D. F., Björnsdóttir, U. S., Halapi, E. C., Helgadóttir, A., Sulem, P., Jonsdottir, G. M., Þorleifsson, G., Helgadottir, H. T., Steinthórsdóttir, V., Stefánsson, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.323 · Cited by 761 · see citing works

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

Helgadóttir, A., Þorleifsson, G., Magnússon, K. P., Grétarsdóttir, S., Steinthórsdóttir, V., Manolescu, A. R., Jones, G. T., Rinkel, G. J. E., Blankensteijn, J. D., Ronkainen, A., et al. (2008) · Nature Genetics · doi:10.1038/ng.72 · Cited by 724 · see citing works

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

Trégouët, D., König, I. R., Erdmann, J., Munteanu, A., Braund, P. S., Hall, A. S., Großhennig, A., Linsel‐Nitschke, P., Perret, C., DeSuremain, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.314 · Cited by 474 · see citing works

Prediction of Coronary Heart Disease Risk using a Genetic Risk Score: The Atherosclerosis Risk in Communities Study

Morrison, A. C., Bare, L. A., Chambless, L. E., Ellis, S. G., Malloy, M. J., Kane, J. P., Pankow, J. S., Devlin, J. J., Willerson, J. T., & Boerwinkle, E. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm060 · Cited by 280 · see citing works

Nonvalidation of Reported Genetic Risk Factors for Acute Coronary Syndrome in a Large-Scale Replication Study

Morgan, T. M., Krumholz, H. M., Lifton, R. P., & Spertus, J. A. (2007) · JAMA · doi:10.1001/jama.297.14.1551 · Cited by 270 · see citing works

Has the revolution arrived?

Collins, F. S. (2010) · Nature · doi:10.1038/464674a · Cited by 248 · see citing works

Association of the Trp719Arg Polymorphism in Kinesin-Like Protein 6 With Myocardial Infarction and Coronary Heart Disease in 2 Prospective Trials

Iakoubova, O. A., Tong, C. H., Rowland, C. M., Kirchgessner, T. G., Young, B. A., Arellano, A. R., Shiffman, D., Sabatine, M. S., Campos, H., Packard, C. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.05.057 · Cited by 170 · see citing works

Association of Gene Variants With Incident Myocardial Infarction in the Cardiovascular Health Study

Shiffman, D., O’Meara, E. S., Bare, L. A., Rowland, C. M., Louie, J. Z., Arellano, A. R., Lumley, T., Rice, K. M., Iakoubova, O. A., Luke, M. M., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.153981 · Cited by 167 · see citing works

Polymorphism in KIF6 Gene and Benefit From Statins After Acute Coronary Syndromes

Iakoubova, O. A., Sabatine, M. S., Rowland, C. M., Tong, C. H., Catanese, J. J., Ranade, K., Simonsen, K. L., Kirchgessner, T. G., Cannon, C. P., Devlin, J. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.017 · Cited by 150 · see citing works

SNPs in BRAP associated with risk of myocardial infarction in Asian populations

Ozaki, K., Sato, H., Inoue, K., Tsunoda, T., Sakata, Y., Mizuno, H., Lin, T., Miyamoto, Y., Aoki, A., Onouchi, Y., et al. (2009) · Nature Genetics · doi:10.1038/ng.326 · Cited by 106 · see citing works

A Kinesin Family Member 6 Variant Is Associated With Coronary Heart Disease in the Women’s Health Study

Shiffman, D., Chasman, D. I., Zee, R. Y. L., Iakoubova, O. A., Louie, J. Z., Devlin, J. J., & Ridker, P. M. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.044 · Cited by 103 · see citing works

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

Assimes, T. L., Hólm, H., Kathiresan, S., Reilly, M. P., Þorleifsson, G., Voight, B. F., Erdmann, J., Willenborg, C., Vaidya, D. M., Xie, C., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.06.022 · Cited by 85 · see citing works

Future Use of Genomics in Coronary Artery Disease

Damani, S. B., & Topol, E. J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.062 · Cited by 64 · see citing works

Surprises of the Genome and “Personalized” Medicine⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

Marian, A. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.020 · Cited by 16 · see citing works

Association of the 719Arg Variant of KIF6 With Both Increased Risk of Coronary Events and With Greater Response to Statin Therapy

Iakoubova, O. A., Shepherd, J., & Sacks, F. M. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.061 · Cited by 13 · see citing works

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

Richards, S., Aziz, N., Bale, S., Bick, D., Das, S., Gastier-Foster, J., Grody, W. W., Hegde, M., Lyon, E., Spector, E., et al. (2015) · Genetics in Medicine · doi:10.1038/gim.2015.30 · Cited by 32,594 · see citing works

Kinesin-Like Protein 6 (KIF6) Polymorphism and the Efficacy of Rosuvastatin in Primary Prevention

Ridker, P. M., MacFadyen, J. G., Glynn, R. J., & Chasman, D. I. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.110.959353 · Cited by 49 · see citing works

Emerging Genomic Applications in Coronary Artery Disease

Damani, S. B., & Topol, E. J. (2011) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2010.12.016 · Cited by 40 · see citing works

FDA Regulation of Laboratory-Developed Diagnostic Tests

Sharfstein, J. M. (2015) · JAMA · doi:10.1001/jama.2014.18135 · Cited by 36 · see citing works

Physician Liability: The Next Big Thing for Personalized Medicine?

Marchant, G. E., Campos-Outcalt, D. E., & Lindor, R. A. (2011) · Personalized Medicine · doi:10.2217/pme.11.33 · Cited by 28 · see citing works

A Common KIF6 Polymorphism Increases Vulnerability to Low-Density Lipoprotein Cholesterol: Two Meta-Analyses and a Meta-Regression Analysis

Ference, B. A., Yoo, W., Flack, J. M., & Clarke, M. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028834 · Cited by 25 · see citing works

Genetics and Personalized Medicine—a Role in Statin Therapy?

Patel, J., Abd, T., Blumenthal, R. S., Nasir, K., & Superko, H. R. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0384-y · Cited by 21 · see citing works

Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men

Hubacek, J. A., Vrablı́k, M., Dlouhá, D., Staněk, V., Gebauerova, M., Adámková, V., Češka, R., Dostálová, G., Linhart, A., Vı́tek, L., et al. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.01.005 · Cited by 20 · see citing works

Interpreting the clinical utility of a pharmacogenomic marker based on observational association studies

Sorich, M. J., & Coory, M. D. (2013) · The Pharmacogenomics Journal · doi:10.1038/tpj.2013.35 · Cited by 17 · see citing works

Statin Pharmacogenomics: Opportunities to Improve Patient Outcomes and Healthcare Costs with Genetic Testing

Canestaro, W. J., Brooks, D. G., Chaplin, D., Choudhry, N. K., Lawler, E. V., Martell, L. A., Brennan, T. A., & Wassman, E. R. (2012) · Journal of Personalized Medicine · doi:10.3390/jpm2040158 · Cited by 17 · see citing works

Association of KIF6 Variant with Lipid Level and Angiographic Coronary Artery Disease Events Risk in the Han Chinese Population

Wu, G., Li, G.-B., & Dai, B. (2012) · Molecules · doi:10.3390/molecules170911269 · Cited by 14 · see citing works

No Evidence for Cardiac Dysfunction in Kif6 Mutant Mice

Hameed, A. G., Bennett, E., Ciani, B., Hoebers, L. P. C., Milner, R. D. B., Lawrie, A., Francis, S., & Grierson, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054636 · Cited by 8 · see citing works

Are KIF6 and APOE polymorphisms associated with power and endurance athletes?

Wojciechowicz, B., Laguette, M.-J. N., Sawczuk, M., Humińska‐Lisowska, K., Maciejewska, A., Ficek, K., Michałowska‐Sawczyn, M., Leońska‐Duniec, A., Kaczmarczyk, M., Chycki, J., et al. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2020.1817983 · Cited by 6 · see citing works

Developing context-specific next-generation sequencing policy

Curnutte, M., Frumovitz, K. L., Bollinger, J. M., Cook-Deegan, R. M., McGuire, A. L., & Majumder, M. A. (2016) · Nature Biotechnology · doi:10.1038/nbt.3545 · Cited by 4 · see citing works

Investigation ofKIF6Trp719Arg gene polymorphism in a case-control study of coronary artery disease and non-fatal myocardial infarction in the Eastern Province of Saudi Arabia

Vatte, C., Cyrus, C., Shehri, A. M. A., Chathoth, S., Almansori, M., Al-Nafaie, A., Alali, R. A., Al‐Muhanna, F., Asselbergs, F. W., & Ali, A. A. (2016) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2016.21.3.1140 · Cited by 3 · see citing works

FDA oversight of laboratory‐developed tests will facilitate adoption of pharmacogenetic testing into routine clinical care

Hillebrenner, E., Litwack, E. D., Bradley, P., Donigan, K., Lowe, T., Serrano, K., Kelm, K. B., Mansfield, E. A., & Gutierrez, A. (2015) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.521 · Cited by 3 · see citing works

Current Role of Pharmacogenomics in Cardiovascular Medicine

Musunuru, K. (2011) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-011-0129-6 · Cited by 1 · see citing works

KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection

Velasco, J., Li, Y., Ziganshin, B. A., Zafar, M. A., Rizzo, J. A., Ma, D., Zang, H., Kalyanasundaram, A., & Elefteriades, J. A. (2023) · Genes · doi:10.3390/genes14020252 · Cited by 1 · see citing works

Collapse

Harmelin, D. (2002) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2002.tb04602.x

Collapse Therapy

Roberts, L. (1943) · BMJ · doi:10.1136/bmj.1.4298.648-b

Cardiovascular Collapse

Potier, J. C. (2021) · Springer eBooks · doi:10.1007/978-3-319-19650-3_300617

I. The Collapse of American Banking

Willis, H. P. (1934) · Columbia University Press eBooks · doi:10.7312/will93128-004

Television Collapse

Maxwell, J. (1958) · BMJ · doi:10.1136/bmj.1.5083.1352-a