Longitudinal and Circumferential Strain Rate, Left Ventricular Remodeling, and Prognosis After Myocardial Infarction
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Objectives We sought to investigate the clinical prognostic value of longitudinal and circumferential strain (S) and strain rate (SR) in patients after high-risk myocardial infarction (MI).Background Left ventricular (LV) contractile performance after MI is an important predictor of long-term outcome. Tissue deformation imaging might more closely reflect myocardial contractility than traditional measures of systolic functions.Methods The VALIANT (Valsartan in Acute Myocardial Infarction Trial) Echo study enrolled 603 patients with LV dysfunction, heart failure, or both 5 days after MI. We measured global peak longitudinal S and systolic SR (SRs) from apical 4- and 2-chamber views and global circumferential S and SRs from parasternal short-axis view with speckle tracking software (Velocity Vector Imaging, Siemens, Inc., Mountain View, California). We related global S and SRs to LV remodeling at 20-month follow-up and to clinical outcomes.Results Both longitudinal (mean: -5.1 ± 1.6 100/ms) and circumferential SRs (mean: -8.0 ± 2.8 100/ms) were predictive of death or hospital stay for heart failure (hazard ratio: 2.4, 95% confidence interval [CI]: 2.0 to 3.1, p < 0.001; hazard ratio: 1.3, 95% CI: 1.2 to 1.4, p < 0.001, respectively) after adjustment for clinical covariates by Cox proportional hazards, and longitudinal SRs further improved in predicting 18-month survivor on a model based on clinical and standard echocardiographic measures (increase in area under the receiver-operator characteristic curve: 0.13, p = 0.009). With multivariable logistic regression, circumferential SRs, but not longitudinal SRs, was strongly predictive of remodeling (odds ratio: 1.3, 95% CI: 1.1 to 1.4, p < 0.001).Conclusions Both longitudinal and circumferential SRs were independent predictors of outcomes after MI, whereas only circumferential SRs was predictive of remodeling, suggesting that preserved circumferential function might serve to restrain ventricular enlargement after MI.
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Some cardiomyopathies can exhibit maladaptive tissue remodeling that may result in more circumferential alignments of the musculature.
“some cardiomyopathies can exhibit maladaptive tissue remodeling (14, 15), which may result in more circumferential alignments of the musculature (12, 13, 15).”
From Recreating the heart's helical structure-function relationship with focused rotary jet spinning (2022) · cites this paper as [15]
The Discussion describes adverse left-ventricular remodeling after myocardial infarction and relates it to circumferential function. It does not report that remodeling causes the musculature to become more circumferentially aligned; strain and function are not measures of fiber alignment. Page numbers are unavailable in our copy. (LLM, conf=0.82)
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Self-citation
- Authors
- Hung, C.-L., Verma, A., Uno, H., Shin, S.-H., Bourgoun, M., Hassanein, A. H., McMurray, J. J., Velazquez, E. J., Kober, L., Pfeffer, M. A., & Solomon, S. D.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Western Infirmary (GB)
- Duke Medical Center (US)
- Corresponding author
- Solomon, Scott D.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 56
- Issue
- 22
- Pages
- 1812-1822
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2082997321
- Cited by
- 305
- References
- 40
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 13 · 2023: 11 · 2022: 24 · 2021: 26 · 2020: 22 · 2019: 18 · 2018: 26 · 2017: 26 · 2016: 26 · 2015: 18 · 2014: 23 · 2013: 28 · 2012: 15
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- Novartis and Boehringer Ingelheim
- Amgen, Baxter, Bristol-Myers Squibb, Celladon, Novartis, and Sanofi-Aventis
- Novartis
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- strain rate, longitudinal strain, circumferential strain, left ventricular remodeling, prognosis, speckle tracking echocardiography, cardiac contractility, heart failure, mortality
- MeSH terms
- Aged, Biomechanical Phenomena, Female, Humans, Male, Middle Aged, Myocardial Infarction, Prognosis, Ultrasonography, Ventricular Remodeling
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