Cited by 122Peripheral Artery Disease ManagementCardiovascular and exercise physiologyFrailty in Older Adults

Decline in Functional Performance Predicts Later Increased Mobility Loss and Mortality in Peripheral Arterial Disease

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McDermott, Mary M., Liu, Kiang, Ferrucci, Luigi, Tian, Lu, Guralnik, Jack M., Liao, Yihua, Criqui, Michael H.·2011·Journal of the American College of Cardiology

Abstract

Objectives We hypothesized that a greater 2-year decline in office-based functional performance measures would be associated with greater mobility loss and mortality in people with peripheral arterial disease (PAD).Background Associations of decline in functional performance with clinically important outcomes in patients with PAD are unknown.Methods A total of 440 men and women with PAD completed the 6-min walk test and measures of walking velocity at baseline and annually for 2 years. Participants were categorized into tertiles according to their functional decline between baseline and 2-year follow-up and were followed annually after the functional change assessment. Cox proportional hazard models were used to assess relations between the 2-year change in functional performance with later mortality and mobility loss, with adjustments for age, sex, race, ankle brachial index, comorbidities, and other confounders.Results A total of 102 participants (23.2%) died during a median follow-up of 44.5 months after functional change was assessed. Of 319 participants without baseline mobility disability, 60 (18.8%) developed mobility loss after functional change was assessed. Participants in the tertile with the greatest 6-min walk decline had the highest subsequent mobility loss (hazard ratio [HR]: 3.50; 95% confidence interval [CI]: 1.56 to 7.85; p = 0.002), all-cause mortality (HR: 2.16; 95% CI: 1.28 to 3.64; p = 0.004), and cardiovascular disease mortality (HR: 2.45; 95% CI: 1.08 to 5.54; p = 0.031), compared with those with the smallest 6-min walk decline. Greater declines in fastest-paced 4-m walking velocity were associated with higher mobility loss (p trend = 0.018), all-cause mortality (p trend = 0.01), and cardiovascular mortality (p trend = 0.004).Conclusions Participants with PAD with declining functional performance are at increased risk for later mobility loss and mortality.

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Authors
McDermott, M. M., Liu, K., Ferrucci, L., Tian, L., Guralnik, J. M., Liao, Y., & Criqui, M. H.
Affiliations
  • Northwestern University (US)
  • National Institute on Aging (US)
  • University of California San Diego (US)
Corresponding author
McDermott, Mary M.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2011-02
Volume
57
Issue
8
Pages
962-970
ISSN
0735-1097 (ISSN-L)
OpenAlex
W2156171476
Cited by
122
References
22
Citations by year
2026: 2 · 2025: 5 · 2024: 11 · 2023: 10 · 2022: 14 · 2021: 13 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 6
FWCI
8.44
Type
journal article
Language
en
Open access
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL071223, R01HL064739, R01HL076298, R01HL058099)
Topics
  • Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords
peripheral arterial disease, mobility loss, all-cause mortality, cardiovascular mortality, 6-minute walk test, walking speed, functional decline prediction, prognosis
MeSH terms
Age Factors, Aged, Cause of Death, Disability Evaluation, Exercise Test, Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Sex Factors, Time Factors, Cohort Studies, Survival Rate, Proportional Hazards Models, Walking, Exercise Tolerance, Disease Progression, Mobility Limitation, Ankle Brachial Index, Peripheral Arterial Disease

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