The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Risk Stratification in Brugada Syndrome
Open accessAbstract
Objectives The PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) prospective registry was designed to assess the predictive accuracy of sustained ventricular tachycardia/ventricular fibrillation (VTs/VF) inducibility and to identify additional predictors of arrhythmic events in Brugada syndrome patients without history of VT/VF.Background Brugada syndrome is a genetic disease associated with increased risk of sudden cardiac death. Even though its value has been questioned, inducibility of VTs/VF is widely used to select candidates to receive a prophylactic implantable defibrillator, and its accuracy has never been addressed in prospective studies with homogeneous enrolling criteria.Methods Patients with a spontaneous or drug-induced type I electrocardiogram (ECG) and without history of cardiac arrest were enrolled. The registry included 308 consecutive individuals (247 men, 80%; median age 44 years, range 18 to 72 years). Programmed electrical stimulation was performed at enrollment, and patients were followed-up every 6 months.Results During a median follow-up of 34 months, 14 arrhythmic events (4.5%) occurred (13 appropriate shocks of the implantable defibrillator, and 1 cardiac arrest). Programmed electrical stimulation performed with a uniform and pre-specified protocol induced ventricular tachyarrhythmias in 40% of patients: arrhythmia inducibility was not a predictor of events at follow-up (9 of 14 events occurred in noninducible patients). History of syncope and spontaneous type I ECG (hazard ratio [HR]: 4.20), ventricular refractory period <200 ms (HR: 3.91), and QRS fragmentation (HR: 4.94) were significant predictors of arrhythmias.Conclusions Our data show that VT/VF inducibility is unable to identify high-risk patients, whereas the presence of a spontaneous type I ECG, history of syncope, ventricular effective refractory period <200 ms, and QRS fragmentation seem useful to identify candidates for prophylactic implantable cardioverter defibrillator.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A drug-induced type 1 ECG pattern has a lower risk of sudden death than a spontaneous type 1 response.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [371]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Brugada, P., & Brugada, J. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90253-j · Cited by 3,344
Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., CHAITMAN, B. R., FROMER, M. A., Gregoratos, G., Klein, G. J., Myerburg, R. J., Quiñones, M. A., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.010 · Cited by 1,975
Self-citationBrugada Syndrome: Report of the Second Consensus Conference
Antzelevitch, C. N., Brugada, P., Borggrefe, M. M., Brugada, J., Brugada, R., Corrado, D., Gussak, I. B., Marec, H. L., Nademanee, K., Pérez‐Riera, A. R., et al. (2005) · Circulation · doi:10.1161/01.cir.0000152479.54298.51 · Cited by 1,807
Natural History of Brugada Syndrome
Priori, S. G., Napolitano, C., Gasparini, M., Pappone, C., Bella, P. E. D., Giordano, U., Bloise, R., Giustetto, C., Nardis, R. D., Grillo, M., et al. (2002) · Circulation · doi:10.1161/hc1102.105288 · Cited by 1,030
Self-citationAntzelevitch, C., Pollevick, G. D., Cordeiro, J. M., Casis, O., Sanguinetti, M. C., Aizawa, Y., Guerchicoff, A., Pfeiffer, R., Oliva, A., Wollnik, B., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.668392 · Cited by 933
Probst, V., Veltmann, C., Eckardt, L., Meregalli, P. G., Gaita, F., Tan, H. L., Babuty, D., Sacher, F., Giustetto, C., Schulze-Bahr, E., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.887026 · Cited by 847
Proposed Diagnostic Criteria for the Brugada Syndrome
Wilde, A. A. M., Antzelevitch, C. N., Borggrefe, M. M., Brugada, J., Brugada, R., Brugada, P., Corrado, D., Hauer, R. N. W., Kass, R. S., Nademanee, K., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034169.45752.4a · Cited by 844
Self-citationBrugada, R., Brugada, J., Antzelevitch, C. N., Kirsch, G. E., Potenza, D. R., Towbin, J. A., & Brugada, P. (2000) · Circulation · doi:10.1161/01.cir.101.5.510 · Cited by 771
Right Bundle-Branch Block and ST-Segment Elevation in Leads V 1 Through V 3
Brugada, J., Brugada, R., & Brugada, P. (1998) · Circulation · doi:10.1161/01.cir.97.5.457 · Cited by 714
Brugada, J., Brugada, R., Antzelevitch, C. N., Towbin, J. A., Nademanee, K., & Brugada, P. (2002) · Circulation · doi:10.1161/hc0102.101354 · Cited by 624
Flagged first, then by citations
Cited by
Sorted by citations
Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893
Self-citationZeppenfeld, K., Tfelt‐Hansen, J., Riva, M., Winkel, B. G., Behr, E. R., Blom, N. A., Charron, P., Corrado, D., Dagres, N., de Chillou, C., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac262 · Cited by 3,432
Self-citation2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951
Priori, S. G., Wilde, A. A., Horie, M., Cho, Y., Behr, E. R., Berul, C., Blom, N., Brugada, J., Chiang, C.-E., Huikuri, H., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.05.014 · Cited by 1,942
“[73]; 6% event rate at 34 ± 44 months by Priori et al.[70]; 1% event rate after 40 ± 50 months and 30 ± 21 months of follow-up, respectively by Eckardt et al.”
BackgroundResultInfluentialSelf-citationAl‐Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T. M., Field, M. E., Fonarow, G. C., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.054 · Cited by 1,902
Authors Task Force Members, Priori, S. G., Blomström‐Lundqvist, C., Mazzanti, A., Blom, N. A., Borggrefe, M., Camm, J. A., Elliot, P. M., Fitzsimons, D., Hatala, R., et al. (2015) · EP Europace · doi:10.1093/europace/euv319 · Cited by 1,671
Self-citationAl‐Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T. M., Field, M. E., Fonarow, G. C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000549 · Cited by 771
Al‐Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T. M., Field, M. E., Fonarow, G. C., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.10.035 · Cited by 743
Al‐Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T. M., Field, M. E., Fonarow, G. C., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.053 · Cited by 689
J Wave Syndromes Consensus Conference: Emerging Concepts & Gaps in Knowledge
Antzelevitch, C., Yan, G.-X., Ackerman, M., Borggrefe, M., Corrado, D., Guo, J.-H., Gussak, I., Hasdemir, C., Horie, M., Huikuri, H., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.024 · Cited by 239
Al‐Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T. M., Field, M. E., Fonarow, G. C., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.10.036 · Cited by 644
Priori, S. G., Wilde, A. A. M., Horie, M., Cho, Y., Behr, E. R., Berul, C. I., Blom, N. A., Brugada, J., Chiang, C., Huikuri, H. V., et al. (2013) · EP Europace · doi:10.1093/europace/eut272 · Cited by 626
Self-citation2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 478
“B-NR Invasive EPS may be considered in patients wi etiology (297,301,302).”
Background2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya‐Mitjans, À., de Lange, F. J., Deharo, J., Elliot, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martiın, A., et al. (2018) · Kardiologia Polska · doi:10.5603/kp.2018.0161 · Cited by 475
Outcome After Implantation of a Cardioverter-Defibrillator in Patients With Brugada Syndrome
Sacher, F., Probst, V., Maury, P., Babuty, D., Mansourati, J., Komatsu, Y., Marquié, C., Rosa, A., Diallo, A., Cassagneau, R., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.001941 · Cited by 442
“Lead failure, n (%) 3 (10) 29 (16) 28 (17) 0.”
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000499 · Cited by 463
“2012 22192666 (172) Study type: Registry”
Present Status of Brugada Syndrome
Brugada, J., Campuzano, Ó., Arbelo, E., Sarquella‐Brugada, G., & Brugada, R. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.06.037 · Cited by 450
“Syncope is an indisputable risk factor and recognized by all studies, and between 17% and 62% of BrS patients will have a new arrhythmic event 48 to 84 months after diagnosis, which might lead to sudden death (10,58).”
BackgroundAl-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000548 · Cited by 412
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000498 · Cited by 411
“IIb B-NR Invasive EPS may be considered in patients with Brugada ECG pattern and syncope of suspected arrhythmic etiology (199,203,204).”
Background2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.003 · Cited by 327
Outcome After Implantation of a Cardioverter-Defibrillator in Patients With Brugada Syndrome
Sacher, F., Probst, V., Iesaka, Y., Jacon, P., Laborderie, J., Mizon-Gérard, F., Mabo, P., Reuter, S., LAMAISON, D., Takahashi, Y., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.628537 · Cited by 290
Mizusawa, Y., & Wilde, A. A. M. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.111.964577 · Cited by 281
Priori, S. G., Wilde, A. A. M., Horie, M., Cho, Y., Behr, E. R., Berul, C. I., Blom, N. A., Brugada, J., Chiang, C., Huikuri, H. V., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.07.021 · Cited by 272
Self-citationPriori, S. G., Wilde, A. A. M., Horie, M., Cho, Y., Behr, E. R., Berul, C. I., Blom, N. A., Brugada, J., Chiang, C., Huikuri, H. V., et al. (2013) · Journal of Arrhythmia · doi:10.1016/j.joa.2013.07.002 · Cited by 244
“Presence of first-degree AV block and left-axis deviation of the QRS. 3.”
InfluentialSelf-citationNovel Insight Into the Natural History of Short QT Syndrome
Mazzanti, A., Kanthan, A., Monteforte, N., Memmi, M., Bloise, R., Novelli, V., Miceli, C., O’Rourke, S., Borio, G., Zienciuk-Krajka, A., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.078 · Cited by 220
“Interestingly, analogous with what is seen in BrS (20), inducibility of VT/VF at PES is not an independent predictor of risk in SQTS.”
BackgroundInfluentialSelf-citationSroubek, J., Probst, V., Mazzanti, A., Delise, P., Hevia, J. C., Ohkubo, K., Zorzi, A., Champagne, J., Kostopoulou, A., Yin, X., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.017885 · Cited by 242
“Arrhythmia induction may not be reproducible with repeated attempts, potentially limiting the reliability of the technique.(9) As with most studies of Brugada syndrome, follow-up remains limited to several years despite data pooling.”
BackgroundSelf-citationJ-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.
Antzelevitch, C., Yan, G.-X., Ackerman, M., Borggrefe, M., Corrado, D., Guo, J.-H., Gussak, I., Hasdemir, C., Horie, M., Huikuri, H., et al. (2016) · Europace · doi:10.1093/europace/euw235 · Cited by 155
“as well as for patients who present with syncope [49,247,251,263]”
BackgroundA score model to predict risk of events in patients with Brugada Syndrome
Sieira, J. A., Conte, G., Ciconte, G., Chierchia, G., Casado-Arroyo, R., Baltogiannis, G., Giovanni, G. D., Saitoh, Y., Calvo, J. J. C. J., Mugnai, G., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx119 · Cited by 218
“5%, respectively).(2,3) Amongst risk factors, familial history of SCD, EPS inducibility and SND merit special consideration.”
BackgroundMethodInfluentialJCS/JHRS 2019 Guideline on Non-Pharmacotherapy of Cardiac Arrhythmias
Nogami, A., Kurita, T., Abe, H., Andò, K., Ishikawa, T., Imai, K., Usui, A., Okishige, K., Kusano, K., Kumagai, K., et al. (2021) · Circulation Journal · doi:10.1253/circj.cj-20-0637 · Cited by 205
Implantable Cardioverter-Defibrillator Therapy in Brugada Syndrome
Conte, G., Sieira, J., Ciconte, G., de Asmundis, C., Chierchia, G.-B., Baltogiannis, G., Di Giovanni, G., La Meir, M., Wellens, F., Czapla, J., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.12.031 · Cited by 199
“Conversely, the presence of VT or VF inducibility on EPS failed to identify patients at risk for developing arrhythmic events during follow-up (13).”
BackgroundInherited calcium channelopathies in the pathophysiology of arrhythmias
Venetucci, L. A., Denegri, M., Napolitano, C., & Priori, S. G. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.93 · Cited by 187
Self-citationYamagata, K., Horie, M., Aiba, T., Ogawa, S., Aizawa, Y., Ohe, T., Yamagishi, M., Makita, N., Sakurada, H., Tanaka, T., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.027983 · Cited by 181
J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge
Antzelevitch, C., Yan, G.-X., Ackerman, M., Borggrefe, M., Corrado, D., Guo, J.-H., Gussak, I., Hasdemir, C., Horie, M., Huikuri, H., et al. (2016) · Journal of Arrhythmia · doi:10.1016/j.joa.2016.07.002 · Cited by 462
“as well as for patients who present with syncope [49,247,251,263]”
Arrhythmogenic Right Ventricular Cardiomyopathy
Mazzanti, A., Ng, K. K., Faragli, A., Maragna, R., Chiodaroli, E., Orphanou, N., Monteforte, N., Memmi, M., Gambelli, P., Novelli, V., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.09.951 · Cited by 177
“The occurrence of syncope is a common risk predictor in all inherited arrhythmias spanning from long-QT syndrome (20), to Brugada syndrome (21), and to catecholaminergic polymorphic VT (22).”
BackgroundSelf-citationJCS/JHRS 2019 guideline on non‐pharmacotherapy of cardiac arrhythmias
Nogami, A., Kurita, T., Abe, H., Andò, K., Ishikawa, T., Imai, K., Usui, A., Okishige, K., Kusano, K., Kumagai, K., et al. (2021) · Journal of Arrhythmia · doi:10.1002/joa3.12491 · Cited by 166
Genetic, Molecular and Cellular Mechanisms Underlying the J Wave Syndromes
Antzelevitch, C. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-0284 · Cited by 168
Berne, P., & Brugada, J. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-0717 · Cited by 167
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.002 · Cited by 155
“The role of inducibility of VA in identify ng high-risk patients remains controversial (301,302).”
BackgroundA New Electrocardiographic Marker of Sudden Death in Brugada Syndrome
Calò, L., Giustetto, C., Martino, A., Sciarra, L., Cerrato, N., Marziali, M., Rauzino, J., Carlino, G., Ruvo, E. D., Guerra, F., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.01.024 · Cited by 154
Sudden Cardiac Death and Genetic Ion Channelopathies
Napolitano, C., Bloise, R., Monteforte, N., & Priori, S. G. (2012) · Circulation · doi:10.1161/circulationaha.111.055947 · Cited by 152
Self-citationBrugada syndrome: clinical and genetic findings
Sarquella-Brugada, G., Campuzano, Ó., Arbelo, E., Brugada, J., & Brugada, R. (2015) · Genetics in Medicine · doi:10.1038/gim.2015.35 · Cited by 143
J Wave syndromes: Brugada and Early Repolarization Syndromes
Antzelevitch, C., & Yan, G.-X. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.04.014 · Cited by 139
Cardiac Involvement in Sarcoidosis: Evolving Concepts in Diagnosis and Treatment
Hwang, J. D., Bradfield, J. S., Fishbein, M. C., Shivkumar, K., Tung, R. H., & Lynch, J. P. (2014) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0034-1376889 · Cited by 143
“When the clinical presentation is isolated conduction system disease (1st, 2nd, or 3rd degree HB or BBB), the differential includes age-related conduction system disease, Lyme disease, Brugada syndrome, and myocarditis [178,188].”
BackgroundElectrocardiographic Parameters and Fatal Arrhythmic Events in Patients With Brugada Syndrome
Tokioka, K., KUSANO, K. F., Morita, H., Miura, D., Nishii, N., Nagase, S., Nakamura, K., Kohno, K., Ito, H., & Ohe, T. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.072 · Cited by 140
“A recent study showed that f-QRS is the strongest predictor of VF development in BrS (20).”
Krahn, A. D., Behr, E. R., Hamilton, R. M., Probst, V., Laksman, Z., & Han, H. (2022) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2021.12.001 · Cited by 155
Pathogenesis and management of Brugada syndrome
Sieira, J. A., Dendramis, G., & Brugada, P. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.143 · Cited by 131
Kawata, H., Morita, H., Yamada, Y., Noda, T., Satomi, K., Aiba, T., Isobe, M., Nagase, S., Nakamura, K., KUSANO, K. F., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.04.009 · Cited by 131
Brugada Syndrome: Clinical, Genetic, Molecular, Cellular, and Ionic Aspects.
Antzelevitch, C., & Patocskai, B. (2016) · Current problems in cardiology · doi:10.1016/j.cpcardiol.2015.06.002 · Cited by 118
Priori, S. G., Blomström‐Lundqvist, C., Mazzanti, A., Blom, N. A., Borggrefe, M., Camm, A. J., Elliot, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2016) · Revista Española de Cardiología · doi:10.1016/j.recesp.2016.01.001 · Cited by 138
Self-citationManagement of Brugada Syndrome
Belhassen, B., Rahkovich, M., Michowitz, Y., Glick, A., & Viskin, S. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003109 · Cited by 118
Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome
Sieira, J. A., Conte, G., Ciconte, G., de Asmundis, C., Chierchia, G., Baltogiannis, G., Giovanni, G. D., Saitoh, Y., Irfan, G., Casado-Arroyo, R., et al. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.114.002647 · Cited by 113
“A recent metaanalysis found a relation with events in asymptomatic and patients presenting with syncope but great controversy still exists around this topic.(8,14,15) Furthermore, as the risk of SD in BS patients persists lifelong, extended long-term follow-up is of great importance.”
BackgroundMethodMaury, P., Rollin, A., Sacher, F., Gourraud, J.-B., Raczka, F., Pasquié, J.-L., Duparc, A., Mondoly, P., Cardin, C., Delay, M., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.06.033 · Cited by 111
“The presence of fragmented QRS as a marker for altered intraventricular conduction has been shown to be a reliable marker for future major cardiac events.(17,29) Prevalence of fragmented QRS in our population was much lower than reported, probably reflecting differences in populations and/ or electrocardiographic reco…”
BackgroundAdler, A., Rosso, R., Chorin, E., Havakuk, O., Antzelevitch, C. N., & Viskin, S. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.08.038 · Cited by 113
Fragmented QRS: What Is The Meaning?
Take, Y., & Morita, H. (2012) · Indian Pacing and Electrophysiology Journal · doi:10.1016/s0972-6292(16)30544-7 · Cited by 111
“902) as well as spontaneous type 1 ECG, history of syncope, and short ventricular refractory periods [36].”
BackgroundAge of First Arrhythmic Event in Brugada Syndrome
Milman, A., Andorin, A., Gourraud, J., Sacher, F., Mabo, P., Kim, S., Maeda, S., Takahashi, Y., Kamakura, T., Aiba, T., et al. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005222 · Cited by 108
Self-citationFragmented ECG as a Risk Marker in Cardiovascular Diseases
Jain, R., Singh, R., Yamini, S., & Das, M. K. (2014) · Current Cardiology Reviews · doi:10.2174/1573403x10666140514103451 · Cited by 102
“It is to be emphasized that fQRS is a nonspecific finding and should only be interpreted in the presence of pertinent clinical evidence of myocardial scar as in CAD or primary electrical abnormalities of depolarization.”
A Primary Prevention Clinical Risk Score Model for Patients With Brugada Syndrome (BRUGADA-RISK)
Honarbakhsh, S., Providencia, R. A., García-Hernández, J., Martin, C. A., Hunter, R. J., Lim, W. Y., Kirkby, C., Graham, A. J., Sharifzadehgan, A., Waldmann, V., et al. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2020.08.032 · Cited by 101
“Due to the controversial nature of programmed ventricular stimulation as a risk factor for VA/SCD in BrS (2,6,18,20,24), it is not strongly recommended in clinical guidelines (10); only 406 patients (37%) in the current cohort underwent programmed ventricular stimulation as in other published studies (24), and 66% und…”
ResultBrugada syndrome: Diagnosis, risk stratification and management
Gourraud, J., Barc, J., Thollet, A., Marec, H. L., & Probst, V. (2017) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2016.09.009 · Cited by 94
“QRS fragmentation At least four spikes in one or at least eight spikes in all of the precordial leads Increased risk, but needs to be confirmedb [10,40]”
BackgroundInfluentialThe ICD for Primary Prevention in Patients With Inherited Cardiac Diseases
Nordkamp, L. R. A. O., Wilde, A. A. M., Tijssen, J. G. P., Knops, R. E., van Dessel, P. F. H. M., & de Groot, J. R. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.112.975268 · Cited by 94
“Asymptomatic patients with BrS and inducible VT/VF with EPS and LQTS patients with only a family history of SCD are not considered for ICD implantation anymore.(24) The absence of prospective randomized studies makes it difficult to identify patients at risk, and risk factors for SCD and ICD indications have been deri…”
BackgroundGiustetto, C., Cerrato, N., Gribaudo, E., Scrocco, C., Castagno, D., Richiardi, E., Giachino, D. F., Bianchi, F., Barbonaglia, L., Ferraro, A., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.10.043 · Cited by 95
Priori, S. G., Wilde, A. A. M., Horie, M., Cho, Y., Behr, E. R., Berul, C. I., Blom, N. A., Brugada, J., Chiang, C., Huikuri, H. V., et al. (2013) · Journal of Arrhythmia · doi:10.1016/j.joa.2013.08.001 · Cited by 90
“Since the first reporting, the reported annual rate of events has decreased.(27) –34 Several clinical variables have been demonstrated to predict a worse outcome in patients with BrS.”
Self-citationRelationship Between Arrhythmogenic Right Ventricular Cardiomyopathy and Brugada Syndrome
Corrado, D., Zorzi, A., Cerrone, M., Rigato, I., Mongillo, M., Bauce, B., & Delmar, M. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003631 · Cited by 91
“tively investigated in the Programmed Electrical Stimulation Predictive Value (PRELUDE) study.(43)”
BackgroundAssessing the Malignant Ventricular Arrhythmic Substrate in Patients With Brugada Syndrome
Pappone, C., Ciconte, G., Manguso, F., Vicedomini, G., Mecarocci, V., Conti, M. A., Giannelli, L., Pozzi, P., Borrelli, V., Menicanti, L., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.02.022 · Cited by 86
Self-citationLong-Term Trends in Newly Diagnosed Brugada Syndrome
Casado-Arroyo, R., Berne, P., Rao, J. Y., Rodríguez‐Mañero, M., Moisés Levinstein, J., Conte, G., Sieira, J. A., Namdar, M., Ricciardi, D., Chierchia, G., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.05.073 · Cited by 85
“, 2002 (3) PRELUDE Registry, 2012 (10) Delise et al.”
BackgroundMilman, A., Gourraud, J., Andorin, A., Postema, P. G., Sacher, F., Mabo, P., Conte, G., Giustetto, C., Sarquella‐Brugada, G., Hochstadt, A., et al. (2018) · Heart Rhythm · doi:10.1016/j.hrthm.2018.06.019 · Cited by 82
Self-citationSieira, J. A., Ciconte, G., Conte, G., Chierchia, G., de Asmundis, C., Baltogiannis, G., Giovanni, G. D., Saitoh, Y., Irfan, G., Casado-Arroyo, R., et al. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.114.003044 · Cited by 82
“infrequent; none of the major BS registries have a mean follow-up >40 months.(10,11) As the risk of sudden death in patients”
BackgroundMilman, A., Andorin, A., Gourraud, J., Postema, P. G., Sacher, F., Mabo, P., Kim, S., Juang, J. J., Maeda, S., Takahashi, Y., et al. (2018) · Heart Rhythm · doi:10.1016/j.hrthm.2018.01.014 · Cited by 75
Self-citationPrognostic significance of fever-induced Brugada syndrome
Mizusawa, Y., Morita, H., Adler, A., Havakuk, O., Thollet, A., Maury, P., Wang, D. W., Hong, K., Gandjbakhch, E., Sacher, F., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.03.044 · Cited by 76
Veerakul, G., & Nademanee, K. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-1352 · Cited by 75
Ventricular Arrhythmias and Sudden Cardiac Death
Tang, P., Shenasa, M., & Boyle, N. G. (2017) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2017.08.004 · Cited by 76
Asymptomatic Patients With Brugada ECG Pattern: Long-Term Prognosis From a Large Prospective Study
Gaïta, F., Cerrato, N., Giustetto, C., Martino, A., Bergamasco, L., Millesimo, M., Barbonaglia, L., Carvalho, P., Caponi, D., Saglietto, A., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.064689 · Cited by 75
“23,26 More recently, the metanalysis from Sroubek et al 27 demonstrated that induction of VT or VF at EPS was a marker of arrhythmic risk in the overall Brugada population; however, a consensus has not yet been reached.”
Li, K. H. C., Lee, S.-R., Yin, C.-S., Liu, T., Ngarmukos, T., Conte, G., Yan, G.-X., Sy, R., Letsas, K., & Tse, G. (2020) · International Journal of Cardiology: Heart & Vasculature · doi:10.1016/j.ijcha.2020.100468 · Cited by 69
Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome
Michowitz, Y., Milman, A., Andorin, A., Sarquella‐Brugada, G., Corcia, M. C. G., Gourraud, J., Conte, G., Sacher, F., Juang, J. J., Kim, S., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.01.048 · Cited by 72
“5%) children (2), reports have mainly focused on adults who constitute the majority of symptomatic patients (3,4).”
BackgroundSelf-citationRisk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest
Okamura, H., Kamakura, T., Morita, H., Tokioka, K., Nakajima, I., Wada, M., Ishibashi, K., Miyamoto, K., Noda, T., Aiba, T., et al. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-1059 · Cited by 70
About Brugada syndrome and its prevalence
Postema, P. G. (2012) · EP Europace · doi:10.1093/europace/eus042 · Cited by 69
“The most recent evidence in this debate comes from the Italian PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) study.(5) In this large prospective study, inducibility of arrhythmias had no additive value in asymptomatic patients—an important message to the community.”
BackgroundRollin, A., Sacher, F., Gourraud, J., Pasquié, J., Raczka, F., Duparc, A., Mondoly, P., Cardin, C., Delay, M., Chatel, S., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.03.001 · Cited by 68
Mahida, S., Derval, N., Sacher, F., Leenhardt, A., Deisenhofer, I., Babuty, D., Schläpfer, J., Roy, L. D., Frank, R., Yli‐Mäyry, S., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.10.043 · Cited by 67
“Age at first VF, yrs 36 13 Male/female 60/21 Family history of SCD 18/81 (22)”
BackgroundClinical characterisation and long-term prognosis of women with Brugada syndrome
Sieira, J. A., Conte, G., Ciconte, G., de Asmundis, C., Chierchia, G., Baltogiannis, G., Giovanni, G. D., Saitoh, Y., Irfan, G., Casado-Arroyo, R., et al. (2016) · Heart · doi:10.1136/heartjnl-2015-308556 · Cited by 67
Epidemiology of inherited arrhythmias
Offerhaus, J. A., Bezzina, C. R., & Wilde, A. A. M. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0266-2 · Cited by 66
Inherited arrhythmias: The cardiac channelopathies
Behere, S. P., & Weindling, S. (2015) · Annals of Pediatric Cardiology · doi:10.4103/0974-2069.164695 · Cited by 66
“[15] Additionally, there are nontrivial false positive and false negative rates with EPT, as well as poor reproducibility.[17]”
BackgroundSingh, M., Morin, D. P., & Link, M. S. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2019.05.006 · Cited by 66
JCS/JHRS 2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia
Takase, B., Ikeda, T., Shimizu, W., Abe, H., Aiba, T., Chinushi, M., Koba, S., KUSANO, K. F., Niwano, S., Takahashi, N., et al. (2023) · Circulation Journal · doi:10.1253/circj.cj-22-0827 · Cited by 68
Gray, B. R., Kirby, A. C., Kabunga, P., Freedman, S. B., Yeates, L., Kanthan, A., MEDI, C., KEECH, A. C., Semsarian, C., & Sy, R. W. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.02.026 · Cited by 62
Kawazoe, H., Nakano, Y., Ochi, H., Takagi, M., Hayashi, Y., Uchimura, Y., Tokuyama, T., Watanabe, Y., Matsumura, H., Tomomori, S., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.07.009 · Cited by 60
The Brugada Syndrome: A Rare Arrhythmia Disorder with Complex Inheritance
Gourraud, J., Barc, J., Thollet, A., Scouarnec, S. L., Marec, H. L., Schott, J., Redon, R., & Probst, V. (2016) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2016.00009 · Cited by 62
Kusumoto, F. M., Bailey, K. R., Chaouki, A. S., Deshmukh, A. J., Gautam, S., Kim, R. J., Kramer, D. B., Lambrakos, L. K., Nasser, N. H., & Sorajja, D. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.10.037 · Cited by 59
Update on the Diagnosis and Management of Brugada Syndrome.
Vohra, J., & Rajagopalan, S. (2015) · Heart, Lung and Circulation · doi:10.1016/j.hlc.2015.07.020 · Cited by 56
“History of syncope, spontaneous Type 1 Brugada pattern, ERP <200msec and QRS fragmentation were predictive of increased risk [42].”
BackgroundTpeak–Tendinterval and Tpeak–Tend/QT ratio in patients with Brugada syndrome
Zumhagen, S., Zeidler, E. M., Stallmeyer, B., Ernsting, M., Eckardt, L., & Schulze‐Bahr, E. (2016) · EP Europace · doi:10.1093/europace/euw033 · Cited by 54
Kusumoto, F. M., Bailey, K. R., Chaouki, A. S., Deshmukh, A. J., Gautam, S., Kim, R. J., Kramer, D. B., Lambrakos, L. K., Nasser, N. H., & Sorajja, D. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.052 · Cited by 52
Cerrato, N., Giustetto, C., Gribaudo, E., Richiardi, E., Barbonaglia, L., Scrocco, C., Zema, D., & Gaita, F. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.10.007 · Cited by 48
on behalf of Fragmented QRS in Hypertrophic Obstructive Cardiomyopathy (FHOCM) Study Investigators, Femenía, F., Arce, M. A., Grieken, J. V., Trucco, E., Mont, L., Abello, M., Merino, J. L., Rivero‐Ayerza, M., Görenek, B., et al. (2013) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-013-9829-z · Cited by 49
Genetics of ion-channel disorders
Cerrone, M., Napolitano, C., & Priori, S. G. (2012) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328352429d · Cited by 49
Self-citationAge at diagnosis of Brugada syndrome: Influence on clinical characteristics and risk of arrhythmia
Minier, M., Probst, V., Berthome, P., Tixier, R., Briand, J., Geoffroy, O., Clémenty, N., Mansourati, J., Jesel, L., Dupuis, J., et al. (2019) · Heart Rhythm · doi:10.1016/j.hrthm.2019.11.027 · Cited by 49
Brugada syndrome: A general cardiologist's perspective
Polovina, M. M., VUKIĆEVIĆ, M., Banko, B., Lip, G. Y. H., & Potpara, T. (2017) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2017.06.019 · Cited by 49
Letsas, K., Asvestas, D., Baranchuk, A., Liu, T., Georgopoulos, S., Efremidis, M., Korantzopoulos, P., Bazoukis, G., Tse, G., Sideris, A., et al. (2017) · Pacing and clinical electrophysiology : PACE · doi:10.1111/pace.13214 · Cited by 46
Kamakura, T., Wada, M., Nakajima, I., Ishibashi, K., Miyamoto, K., Okamura, H., Noda, T., Aiba, T., Takaki, H., Yasuda, S., et al. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.114.002705 · Cited by 47
“At the time of diagnosis (%) 3 (8) 5 (9) 3 (10) 0.”
Brugada Syndrome: Progress in Diagnosis and Management
Pappone, C., & Santinelli, V. (2019) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2018.73.2 · Cited by 46
“Data suggest this latter group is at very low risk and that the presumed false-positive rate of pharmacological challenge is not trivial.(14) ECG should thus be routinely performed when a diagnosis of BrS is suspected but is uncertain on a standard ECG, and in screening family members of BrS patients (Figure 1).”
BackgroundSelf-citationUpdate on Brugada Syndrome 2019
Coppola, G., Corrado, E., Curnis, A., Maglia, G., Oriente, D., Mignano, A., & Brugada, P. (2019) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2019.100454 · Cited by 48
Lee, S., Zhou, J., Li, K. H. C., Leung, K. S. K., Lakhani, I., Liu, T., Wong, I. C. K., Mok, N. S., Mak, C. M., Jeevaratnam, K., et al. (2021) · Open Heart · doi:10.1136/openhrt-2020-001505 · Cited by 45
Mazzanti, A., O’Rourke, S., Ng, K. K., Miceli, C., Borio, G., Curcio, A., Esposito, F., Napolitano, C., & Priori, S. G. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.894884 · Cited by 46
“The combined presence of a spontaneous type 1 ECG at baseline and a history of syncope identify subjects at risk of CA [46,48].”
BackgroundSelf-citation
Metadata
- Authors
- Priori, S. G., Gasparini, M., Napolitano, C., Della Bella, P., Ottonelli, A. G., Sassone, B., Giordano, U., Pappone, C., Mascioli, G., Rossetti, G., De Nardis, R., & Colombo, M.
- Affiliations
- University of Pavia (IT)
- IRCCS Humanitas Research Hospital (IT)
- NYU Langone Health (US)
- Ospedale Versilia (IT)
- Azienda USL di Bologna (IT)
- Maria Cecilia Hospital (IT)
- Humanitas Gavazzeni (IT)
- Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT)
- Corresponding author
- Priori, Silvia G.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 59
- Issue
- 1
- Pages
- 37-45
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W140924846
- Cited by
- 581
- References
- 26
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 26 · 2023: 25 · 2022: 26 · 2021: 44 · 2020: 43 · 2019: 44 · 2018: 44 · 2017: 68 · 2016: 60 · 2015: 45 · 2014: 31 · 2013: 66 · 2012: 30
- FWCI
- 28.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Medtronic
- Boston Scientific Corporation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- Brugada syndrome, risk stratification, programmed electrical stimulation, implantable cardioverter-defibrillator, sudden cardiac death, syncope, ventricular effective refractory period, QRS fragmentation, arrhythmic events
- MeSH terms
- Adolescent, Adult, Aged, Cause of Death, Electric Stimulation, Electrocardiography, Female, Humans, Male, Middle Aged, Registries, Severity of Illness Index, Ventricular Fibrillation, Cohort Studies, Incidence, Survival Rate, Confidence Intervals, Defibrillators, Implantable, Tachycardia, Ventricular, Age Distribution, Sex Distribution, Risk Assessment, Patient Selection, Statistics, Nonparametric, Kaplan-Meier Estimate, Brugada Syndrome, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
