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Risk Stratification in Brugada Syndrome
Open accessAbstract
Objectives The PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) prospective registry was designed to assess the predictive accuracy of sustained ventricular tachycardia/ventricular fibrillation (VTs/VF) inducibility and to identify additional predictors of arrhythmic events in Brugada syndrome patients without history of VT/VF.Background Brugada syndrome is a genetic disease associated with increased risk of sudden cardiac death. Even though its value has been questioned, inducibility of VTs/VF is widely used to select candidates to receive a prophylactic implantable defibrillator, and its accuracy has never been addressed in prospective studies with homogeneous enrolling criteria.Methods Patients with a spontaneous or drug-induced type I electrocardiogram (ECG) and without history of cardiac arrest were enrolled. The registry included 308 consecutive individuals (247 men, 80%; median age 44 years, range 18 to 72 years). Programmed electrical stimulation was performed at enrollment, and patients were followed-up every 6 months.Results During a median follow-up of 34 months, 14 arrhythmic events (4.5%) occurred (13 appropriate shocks of the implantable defibrillator, and 1 cardiac arrest). Programmed electrical stimulation performed with a uniform and pre-specified protocol induced ventricular tachyarrhythmias in 40% of patients: arrhythmia inducibility was not a predictor of events at follow-up (9 of 14 events occurred in noninducible patients). History of syncope and spontaneous type I ECG (hazard ratio [HR]: 4.20), ventricular refractory period <200 ms (HR: 3.91), and QRS fragmentation (HR: 4.94) were significant predictors of arrhythmias.Conclusions Our data show that VT/VF inducibility is unable to identify high-risk patients, whereas the presence of a spontaneous type I ECG, history of syncope, ventricular effective refractory period <200 ms, and QRS fragmentation seem useful to identify candidates for prophylactic implantable cardioverter defibrillator.
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“A drug-induced type 1 ECG pattern has a lower risk of sudden death than a spontaneous type 1 response.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [371]
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Brugada, P., & Brugada, J. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90253-j · Cited by 3,344
Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., CHAITMAN, B. R., FROMER, M. A., Gregoratos, G., Klein, G. J., Myerburg, R. J., Quiñones, M. A., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.010 · Cited by 1,975
Self-citationBrugada Syndrome: Report of the Second Consensus Conference
Antzelevitch, C. N., Brugada, P., Borggrefe, M. M., Brugada, J., Brugada, R., Corrado, D., Gussak, I. B., Marec, H. L., Nademanee, K., Pérez‐Riera, A. R., et al. (2005) · Circulation · doi:10.1161/01.cir.0000152479.54298.51 · Cited by 1,807
Natural History of Brugada Syndrome
Priori, S. G., Napolitano, C., Gasparini, M., Pappone, C., Bella, P. E. D., Giordano, U., Bloise, R., Giustetto, C., Nardis, R. D., Grillo, M., et al. (2002) · Circulation · doi:10.1161/hc1102.105288 · Cited by 1,030
Self-citationAntzelevitch, C., Pollevick, G. D., Cordeiro, J. M., Casis, O., Sanguinetti, M. C., Aizawa, Y., Guerchicoff, A., Pfeiffer, R., Oliva, A., Wollnik, B., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.668392 · Cited by 933
Probst, V., Veltmann, C., Eckardt, L., Meregalli, P. G., Gaita, F., Tan, H. L., Babuty, D., Sacher, F., Giustetto, C., Schulze-Bahr, E., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.887026 · Cited by 847
Proposed Diagnostic Criteria for the Brugada Syndrome
Wilde, A. A. M., Antzelevitch, C. N., Borggrefe, M. M., Brugada, J., Brugada, R., Brugada, P., Corrado, D., Hauer, R. N. W., Kass, R. S., Nademanee, K., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034169.45752.4a · Cited by 844
Self-citationBrugada, R., Brugada, J., Antzelevitch, C. N., Kirsch, G. E., Potenza, D. R., Towbin, J. A., & Brugada, P. (2000) · Circulation · doi:10.1161/01.cir.101.5.510 · Cited by 771
Right Bundle-Branch Block and ST-Segment Elevation in Leads V 1 Through V 3
Brugada, J., Brugada, R., & Brugada, P. (1998) · Circulation · doi:10.1161/01.cir.97.5.457 · Cited by 714
Brugada, J., Brugada, R., Antzelevitch, C. N., Towbin, J. A., Nademanee, K., & Brugada, P. (2002) · Circulation · doi:10.1161/hc0102.101354 · Cited by 624
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Yang, Y., Hu, D., Sacher, F., KUSANO, K. F., Li, X., Barajas-Martínez, H., Hocini, M., Li, Y., Gao, Y., Shang, H., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00103 · Cited by 18
Brugada burden in Brugada syndrome: The way to go in risk stratification?
Viskin, S., Adler, A., & Rosso, R. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.04.010 · Cited by 18
JCS / JHRS 2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia
Takase, B., Ikeda, T., Shimizu, W., Abe, H., Aiba, T., Chinushi, M., Koba, S., KUSANO, K. F., Niwano, S., Takahashi, N., et al. (2024) · Journal of Arrhythmia · doi:10.1002/joa3.13052 · Cited by 19
Baranchuk, A. M., Femenía, F., Diez, J. C. L., Muratore, C. A., Valentino, M., Retyk, E., Galizio, N. O., Toro, D. D., Alonso, K., Hopman, W. M., et al. (2013) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12077 · Cited by 17
Risk Stratification and Treatment of Brugada Syndrome
Arbelo, E., & Brugada, J. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0508-1 · Cited by 22
Lombardi, R. (2013) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32835fb7f3 · Cited by 17
Béhar, N., Petit, B., Probst, V., Sacher, F., Kervio, G., Mansourati, J., Bru, P., Hernandez, A. I., & Mabo, P. (2016) · EP Europace · doi:10.1093/europace/euw224 · Cited by 17
The Brugada Syndrome – Diagnosis, Clinical Implications and Risk Stratification
Batchvarov, V. N. (2014) · European Cardiology Review · doi:10.15420/ecr.2014.9.2.82 · Cited by 17
“9 %).(85) Currently its role of EPS for risk stratification is accepted only as a Class IIb (“may be considered”) indication.”
BackgroundLi, X., Sacher, F., KUSANO, K. F., Barajas-Martínez, H., Liu, N., Li, Y., Gao, Y., Liu, T., Shang, H., Antzelevitch, C. N., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01951 · Cited by 17
Sakhi, R., Assaf, A., Theuns, D. A. M. J., Verhagen, J. M. A., Szili‐Törok, T., Roos‐Hesselink, J. W., & Yap, S. (2020) · Cardiology · doi:10.1159/000507075 · Cited by 17
Ajmaline Testing and the Brugada Syndrome
Rizzo, A., Borio, G., Sieira, J. A., Dooren, S. V., Overeinder, I., Bala, G., Pappaert, G., Maj, R., Osório, T. G., Terasawa, M., et al. (2020) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2020.08.024 · Cited by 17
Cardiac arrest and Brugada syndrome: Is drug-induced type 1 ECG pattern always a marker of low risk?
Delise, P., Allocca, G., Sitta, N., Migliore, F., Dagradi, F., Spazzolini, C., Sciarra, L., Carinci, V., Corrado, D., Calò, L., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.10.118 · Cited by 16
Single Oral Flecainide Dose to Unmask Type 1 Brugada Syndrome Electrocardiographic Pattern
Dubner, S., Azocar, D., Gallino, S., CERANTONIO, A., Muryán, S., Medrano, J., & Bruno, C. (2013) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12052 · Cited by 16
Incidence and Clinical Significance of Brugada Syndrome Masked by Complete Right Bundle-Branch Block
Wada, T., Nagase, S., Morita, H., Nakagawa, K., Nishii, N., Nakamura, K., Kohno, K., Ito, H., KUSANO, K. F., & Ohe, T. (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0618 · Cited by 14
Martin, C., Orini, M., Srinivasan, N. T., Bhar-Amato, J., Honarbakhsh, S., CHOW, A. W. C., LOWE, M. D., Simón, R., Elliot, P. M., Taggart, P. I., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.05.063 · Cited by 16
Shinohara, T., Takagi, M., Kamakura, T., Sekiguchi, Y., Yokoyama, Y., Aihara, N., Hiraoka, M., Aonuma, K., & for the Japan Idiopathic Ventricular Fibrillation Study (J‐IVFS) Investigators (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14848 · Cited by 16
“Although a small cohort may limit result interpretation, results in the present study are similar to those described in previous research.(2,8) Second, a different stimulation protocol for PES may result in a different conclusion.”
BackgroundMethodResultInfluentialRandazzo, V., Caligari, S., Pasero, E. G. A., Giustetto, C., Saglietto, A., Bertarello, W., Averbuch, A., Marcus-Kalish, M., Zheludev, V. A., & Gaïta, F. (2025) · Sensors · doi:10.3390/s25030824 · Cited by 16
Brugada syndrome: Clinical features, risk stratification, and management
Hayat, S. A., Malik, B., Rudwan, A. A., Abdelghani, M., Mohsen, M., Khan, S. A., Al-Jefairi, N., Mahmoud, E., & Asaad, N. (2020) · Heart Views · doi:10.4103/heartviews.heartviews_44_20 · Cited by 15
“Several studies have demonstrated a positive association between induced PMVT/VF during EPS and the future risk of ventricular arrhythmias, while many have not.[39,42,50,51] An important limitation and bias of studies in this area is that patients with a positive EPS are more likely to proceed to ICD implantation.”
BackgroundClinical Management of Brugada Syndrome: Commentary From the Experts
Cutler, M. J., Eckhardt, L. L., Kaufman, E. S., Arbelo, E., Behr, E. R., Brugada, P., Cerrone, M., Crotti, L., de Asmundis, C., Gollob, M. H., et al. (2023) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.123.012072 · Cited by 15
“11,26,30,31 In particular, the incremental value of VF inducibility is questionable in the present case if the patient is deemed to have arrhythmic syncope because a negative test would be insufficient to withhold recommending an ICD.”
BackgroundPredicting and Recognizing Drug‐Induced Type I Brugada Pattern Using ECG‐Based Deep Learning
Călburean, P., Pannone, L., Monaco, C., Rocca, D. G. D., Sorgente, A., Almorad, A., Bala, G., Aglietti, F., Ramak, R., Overeinder, I., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.033148 · Cited by 15
Clinical importance of lead aVR in arrhythmogenic cardiomyopathy
Peters, S. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.07.053 · Cited by 15
“QRS fragmentation is a prognostic criterion in hypertrophic cardiomyopathy [9], dilated cardiomyopathy [10], Brugada syndrome [11], Ebstein anomaly [12] and coronary artery disease [13].”
BackgroundMultiple serial ECGs aid with the diagnosis and prognosis of Brugada syndrome
Hevia, J. C., Sánchez, M. D., López, F. M., Chirino, O. C., Rodríguez, R. F., Bravo, M. V. P., Galguera, J. D. Z., & Antzelevitch, C. N. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.08.089 · Cited by 15
“A spontaneous coved-type ST segment elevation in the electrocardiogram (ECG) has long been recognized as a risk stratification tool in patients with Brugada syndrome (BrS), particularly in asymptomatic cases or following syncope of doubtful arrhythmic cause [1-3].”
BackgroundLow‐Voltage Type 1 ECG Is Associated With Fatal Ventricular Tachyarrhythmia in Brugada Syndrome
Nagase, S., Kamakura, T., Kataoka, N., Wada, M., Yamagata, K., Ishibashi, K., Inoue, Y. Y., Miyamoto, K., Noda, T., Aiba, T., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009713 · Cited by 15
“The results of our study did not elucidate the mechanisms of ECGs exhibiting type 1 and the occurrence of polymorphic ventricular tachycardia and VF in BrS.”
BackgroundInfluentialBrugada Syndrome: Progress in Genetics, Risk Stratification and Management
Romero, J. E., Li, D. ‘., Avendaño, R., Díaz, J. C., Tung, R. H., & Biase, L. D. (2019) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2018.66.2 · Cited by 15
Insights for Stratification of Risk in Brugada Syndrome
Iglesias, D. G., Rubín, J. M., Pérez, D., Morı́s, C., & Calvo, D. (2019) · European Cardiology Review · doi:10.15420/ecr.2018.31.2 · Cited by 15
Asada, S., Morita, H., Watanabe, A., Nakagawa, K., Nagase, S., Miyamoto, M., Morimoto, Y., Kawada, S., Nishii, N., & Ito, H. (2020) · EP Europace · doi:10.1093/europace/euaa003 · Cited by 15
Iacopino, S., Chierchia, G., Sorrenti, P. F., Pesce, F., Colella, J., Fabiano, G., Campagna, G., Petretta, A., Placentino, F., Filannino, P., et al. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.08.014 · Cited by 15
Özyılmaz, S. (2017) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2017.7593 · Cited by 15
“On the other hand, fQRS is not specific for coronary artery disease and has also been observed in other myocardial diseases associated with arrhythmias, such as dilated cardiomyopathy (16, 17), Chagas’ disease (18), ion channel disease such as Brugada (19) and long QT syndrome (20), some congenital heart diseases such…”
BackgroundA novel prediction model for risk stratification in patients with a type 1 Brugada ECG pattern
Subramanian, M., Prabhu, M. A., Rai, M., Harikrishnan, M. S., Sekhar, S., Pai, P. G., & Natarajan, K. U. (2019) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2019.04.006 · Cited by 15
The utility of drug challenge testing in Brugada syndrome: A systematic review and meta‐analysis
Rattanawong, P., Kewcharoen, J., Kanitsoraphan, C., Vutthikraivit, W., Putthapiban, P., Prasitlumkum, N., Mekraksakit, P., Mekritthikrai, R., & Chung, E. H. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14631 · Cited by 17
Sen, F., Yılmaz, S., Kuyumcu, M. S., Özeke, Ö., Balcı, M. M., & Aydoğdu, S. (2014) · Korean Circulation Journal · doi:10.4070/kcj.2014.44.5.307 · Cited by 14
ECG interpretation in Brugada syndrome
Nishizaki, M., Yamawake, N., Sakurada, H., & Hiraoka, M. (2013) · Journal of Arrhythmia · doi:10.1016/j.joa.2013.01.001 · Cited by 11
“Moreover, multiple spikes within the QRS complex (fragmented QRS) in leads V1–V3 are known to be a marker of conduction abnormality and a reliable predictor of prognosis [12,25].”
BackgroundResultLeong, K. M. W., Ng, F. S., Jones, S., Chow, J., Qureshi, N. A., Koa‐Wing, M., Linton, N. W. F., Whinnett, Z. I., Lefroy, D. C., Davies, D. W., et al. (2018) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13587 · Cited by 14
Priori, S. G., & Napolitano, C. (2018) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2018.02.009 · Cited by 14
Self-citationYonezu, K., Shinohara, T., Sato, H., Hirota, K., Kondo, H., Fukui, A., Teshima, Y., Yufu, K., Nakagawa, M., & Takahashi, N. (2021) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12873 · Cited by 13
“Our findings are consistent with previous reports (Morita et al., 2008; Tokioka et al., 2014) that fQRS and not positive late potential can predict VF events in BrS patients.”
BackgroundInfluentialZhang, Z., Chen, P., Weiss, J. N., & Qu, Z. (2021) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.121.010365 · Cited by 12
High‐risk atrioventricular block in Brugada syndrome patients with a history of syncope
Kamakura, T., Sacher, F., Katayama, K., Ueda, N., Nakajima, K., Wada, M., Yamagata, K., Ishibashi, K., Inoue, Y. Y., Miyamoto, K., et al. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14876 · Cited by 12
“First‐degree AVB is known to be associated with the occurrence of ventricular arrhythmias in BrS.14,16 No significant difference was found in the incidence of VF between patients with and without high‐ risk AVB, despite the high incidence of first‐degree AVB in patients with high‐risk AVB.”
ResultInfluentialControversies in Brugada syndrome
Cerrone, M. (2017) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2017.11.003 · Cited by 13
“In the PRELUDE study [41], QRS fragmentation was a novel risk indicator, then confirmed by additional series [44].”
BackgroundRighi, D., Porco, L., Calvieri, C., Tamborrino, P. P., Mambro, C. D., Paglia, S., Baban, A., Silvetti, M. S., Gnazzo, M., Novelli, A., et al. (2021) · Heart Rhythm · doi:10.1016/j.hrthm.2021.06.1177 · Cited by 12
The Brugada syndrome: risk stratification
Gaïta, F., Cerrato, N., Saglietto, A., Caponi, D., Calò, L., & Giustetto, C. (2023) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suad035 · Cited by 13
The role of ion channelopathies in sudden cardiac death: Implications for clinical practice
Martin, C., Huang, C. L.-H., & Matthews, G. D. K. (2013) · Annals of Medicine · doi:10.3109/07853890.2013.783994 · Cited by 11
Sacilotto, L., Scanavacca, M., Olivetti, N., Lemes, C. I. S., Pessente, G. D., Wulkan, F., HACHUL, D. T., Krieger, J. E., Pereira, A. C., & Darrieux, F. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14732 · Cited by 12
Role of Catheter Ablation for Ventricular Arrhythmias in Brugada Syndrome
Chokesuwattanaskul, R., & Nademanee, K. (2021) · Current Cardiology Reports · doi:10.1007/s11886-021-01479-2 · Cited by 12
Ageing and Brugada syndrome: considerations and recommendations.
Postema, P. G., Tan, H. L., & Wilde, A. A. M. (2013) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1671-5411.2013.01.012 · Cited by 12
Eranti, A., Aro, A. L., Kenttä, T. V., Holkeri, A., Tikkanen, J. T., Junttila, J. M., & Huikuri, H. V. (2016) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2016.1215520 · Cited by 12
“right precordial leads.[45,46] Subsequent ER pattern in”
Ragab, A. A. Y., Houck, C. A., van der Does, L. J. M. E., Lanters, E. A. H., Muskens, A. J. Q. M., & de Groot, N. M. S. (2018) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13496 · Cited by 12
Current Controversies and Challenges in Brugada Syndrome
Snir, A. D., & Raju, H. (2019) · European Cardiology Review · doi:10.15420/ecr.2019.12.2 · Cited by 11
“Several investigations have demonstrated a positive association between the induction of VT/VF during EPS and the risk of future ventricular arrhythmias, while others have failed to do so.(19,21,24,32,33)”
BackgroundPrognosis after Implantation of Cardioverter-Defibrillators in Korean Patients with Brugada Syndrome
Son, M. K., Byeon, K., Park, S., Kim, J. S., Nam, G., Choi, K., Kim, Y., Park, S. W., Kim, Y., Park, H. W., et al. (2013) · Yonsei Medical Journal · doi:10.3349/ymj.2014.55.1.37 · Cited by 12
(2020) · Annaly aritmologii · doi:10.15275/annaritmol · Cited by 12
The natural history of CVB3 myocarditis in C57BL/6J mice: an extended in-depth characterization
Favere, K., Hecke, M. V., Eens, S., Bosman, M., Stobbelaar, K., Hotterbeekx, A., Kumar‐Singh, S., Delputte, P., Fransén, E., SUTTER, J. D., et al. (2024) · Cardiovascular Pathology · doi:10.1016/j.carpath.2024.107652 · Cited by 11
Sudden cardiac death in the young: the bogeyman
Durante, A., Laforgia, P. L., Aurelio, A., Foglia-Manzillo, G., Bronzato, S., Santarone, M., & Corrado, G. (2014) · Cardiology in the Young · doi:10.1017/s1047951114001723 · Cited by 11
“Moreover, male gender, typical electrocardiogram features at rest, and previous symptoms associate with higher risk for sudden arrhythmic death.(103,113) Nowadays, the only effective preventive strategy in high-risk patients or in secondary prevention is implantable cardioverter–defibrillator implantation.”
BackgroundBrugada Syndrome:Risk Stratification And Management
Aizawa, Y. (2016) · Journal of Atrial Fibrillation · doi:10.4022/jafib.1507 · Cited by 11
Management of Brugada Syndrome 2016: Should All High Risk Patients Receive an ICD?
Sieira, J. A., & Brugada, P. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.116.004195 · Cited by 11
von Hafe, P., Faria, B., Dias, G., Cardoso, F., Alves, M. J., Alves, A., Rodrigues, B., Ribeiro, S., Sanfins, V. M., & Lourenço, A. (2021) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2020.05.013 · Cited by 11
“Brugada syndrome (BrS) is a genetic disease associated with ventricular arrhythmias (VA) and is responsible for 4-12% of cases of sudden cardiac death (SCD).(1) It is characterized by an electrocardiographic (ECG) pattern of ST-segment elevation with type 1 morphology in the right precordial leads V1-V3.”
BackgroundVyas, V. S., & Lambiase, P. D. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00199 · Cited by 11
“However, recent large series have shown that this is not consistent, meaning it has dropped to a class IIb level of evidence in the recent HRS/EHRA Consensus Statement on the assessment of ion channel disorders (Eckardt et al., 2002; Tester and Ackerman, 2011; Priori et al., 2012).”
BackgroundTemız, A., Gazı, E., Altun, B., Güngör, Ö., Barutçu, A., Bekler, A., Tan, Y. Z., Yener, A., Saçar, M., & Çölkesen, Y. (2014) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2014.5467 · Cited by 11
“Secondly, fQRS was found to be associated with ventricular arrhythmias in various conditions, such as ischemic and nonischemic cardiomyopathy (23), hypertrophic cardiomyopathy (15), Brugada syndrome (24), acquired long QT syndrome (25), and arrhythmogenic right ventricular dysplasia (26, 27).”
BackgroundCalvo, D., Flórez, J. P., Valverde, I., Rubín, J. M., Pérez, D., Vasserot, M. G., Rodríguez-Reguero, J., y, P. A., de la Hera, J. M., Gómez, J., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.05.018 · Cited by 11
Brugada Syndrome: Clinical Care Amidst Pathophysiological Uncertainty
Isbister, J. C., Krahn, A. D., Semsarian, C., & Sy, R. W. (2019) · Heart Lung and Circulation · doi:10.1016/j.hlc.2019.11.016 · Cited by 10
“No definitive correlation has been shown between family history of sudden cardiac death (SCD) or SCN5A mutation and an individual’s risk of suffering an arrhythmic event in the future [5,31,33].”
BackgroundECG Features that suggest a potentially life-threatening arrhythmia as the cause for syncope
Marine, J. E. (2013) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2013.07.008 · Cited by 11
New approaches to predicting the risk of sudden death
Behr, E. R., & Ensam, B. (2016) · Clinical Medicine · doi:10.7861/clinmedicine.16-3-283 · Cited by 9
Syncope in patients with inherited arrhythmias
Nakano, Y., & Shimizu, W. (2017) · Journal of Arrhythmia · doi:10.1016/j.joa.2017.07.007 · Cited by 11
Probst, V., & Gourraud, J. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003576 · Cited by 11
Clinical aspects of inherited J-wave syndromes
Huikuri, H. V., & Junttila, J. M. (2014) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.08.008 · Cited by 10
Lozano, I. F. (2016) · Revista Española de Cardiología · doi:10.1016/j.recesp.2015.12.006 · Cited by 10
Chow, J., Leong, K. M. W., Yazdani, M. F., Huzaien, H., Jones, S., Shun-Shin, M. J., Koa‐Wing, M., Lefroy, D. C., Lim, P. B., Linton, N., et al. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.08.035 · Cited by 11
Migliore, F., Martini, N., Calò, L., Martino, A., Winnicki, G., Vio, R., Condello, C., Rizzo, A., Zorzi, A., Pannone, L., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.964694 · Cited by 10
Bernardo, M., & Tiyyagura, S. R. (2018) · American Journal of Case Reports · doi:10.12659/ajcr.906464 · Cited by 10
“In patients with documented ventricular fibrillation, polymorphic ventricular tachycardia, or aborted cardiac death, ICD placement is the only management that decreases mortality [12,13].”
Pranata, R., Yonas, E., Vania, R., & Huang, I. (2019) · Indian Pacing and Electrophysiology Journal · doi:10.1016/j.ipej.2019.06.003 · Cited by 10
Rossi, A., Giannoni, A., Nesti, M., Notarstefano, P., Castiglione, V., Solarino, G., Teresi, L., Mirizzi, G., Russo, V., Panchetti, L., et al. (2022) · EP Europace · doi:10.1093/europace/euac168 · Cited by 10
“559 Dyslipidaemia 35 (9) 11 (6) 24 (12) 0.”
Brugada syndrome: Recent understanding of pathophysiological mechanism and treatment
Kusano, K. (2013) · Journal of Arrhythmia · doi:10.1016/j.joa.2012.12.009 · Cited by 11
“after a large meal [34], abnormal restitution properties [35], effective refractory period in the right ventricle (o200 ms) [36], ST-segment elevation after exercise [37], QT prolongation or shortening, and early repolarization pattern in the inferolateral leads [38].”
BackgroundUnmasking Brugada-Type Electrocardiogram on Deep Inspiration
Yamawake, N., Nishizaki, M., Shimizu, M., Fujii, H., Sakurada, H., & Hiraoka, M. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0576 · Cited by 10
Long-term prognosis of patients with Brugada syndrome and an implanted cardioverter-defibrillator
Dores, H., Santos, K. R., Adragão, P., Costa, F. M., Santos, P. G., Carmo, P., Cavaco, D., Morgado, F. B., & Mendes, M. (2015) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2014.12.006 · Cited by 10
“A positive provocative pharmacological test with flecainide also failed to identify patients with increased risk of appropriate shocks, as described in the PRELUDE Registry.(18) Our results support both the importance of ICD implantation in SCD survivors and the current non-invasive strategy of close follow-up, withou…”
BackgroundResultUpdates on inherited arrhythmia syndromes (Brugada syndrome, long QT syndrome, CPVT, ARVC)
Moore, B. M., Roston, T. M., Laksman, Z., & Krahn, A. D. (2025) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2025.06.002 · Cited by 9
Nagayama, T., Nagase, S., Kamakura, T., Wada, M., Ishibashi, K., Inoue, Y. Y., Miyamoto, K., Noda, T., Aiba, T., Takaki, H., et al. (2019) · Circulation Journal · doi:10.1253/circj.cj-18-0643 · Cited by 9
More than 30 years of Brugada syndrome: a critical appraisal of achievements and open issues
Eckardt, L., & Veltmann, C. (2023) · Herzschrittmachertherapie + Elektrophysiologie · doi:10.1007/s00399-023-00983-y · Cited by 9
Peters, S. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.04.080 · Cited by 9
Fever-induced type 1 Brugada pattern
Madeira, M., Caetano, F., Providencia, R. A., Almeida, I. G., Trigo, J., Nascimento, J., Costa, M. A. D. S., & Marques, A. L. (2015) · Revista Portuguesa de Cardiologia (English Edition) · doi:10.1016/j.repce.2015.03.001 · Cited by 9
Inferolateral early repolarization among non-ischaemic sudden cardiac death victims
Holmström, L. T. A., Haukilahti, M. A. E., Tikkanen, J. T., Aro, A. L., Kenttä, T. V., Kortelainen, M., Huikuri, H. V., & Junttila, J. M. (2017) · EP Europace · doi:10.1093/europace/eux122 · Cited by 9
Brugada type 1 electrocardiogram: Should we treat the electrocardiogram or the patient?
Delise, P., Allocca, G., & Sitta, N. (2017) · World Journal of Cardiology · doi:10.4330/wjc.v9.i9.737 · Cited by 9
Yoon, N., Hong, S. N., Glass, A. M., Kim, S. S., Kim, M. C., Cho, J. Y., Lee, K. H., Sim, D. S., Yoon, H. J., Kim, K. H., et al. (2017) · EP Europace · doi:10.1093/europace/eux281 · Cited by 9
Drago, F., Bloise, R., Bronzetti, G., Leoni, L., Porcedda, G., Sarubbi, B., Filippo, P. D., Gulletta, S., & Scaglione, M. (2020) · Minerva Pediatrics · doi:10.23736/s0026-4946.19.05759-1 · Cited by 10
Common variants in SCN10A gene associated with Brugada syndrome
Huang, Y., Chen, X., Barajas-Martínez, H., Jiang, H., Antzelevitch, C. N., & Hu, D. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab217 · Cited by 9
Genotype–phenotype relationship and risk stratification in loss‐of‐function SCN 5A mutation carriers
Robyns, T., Nuyens, D., Vandenberk, B., Kuipéri, C., Corveleyn, A., Breckpot, J., Garweg, C., Ector, J., & Willems, R. (2018) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12548 · Cited by 8
“Compared to LP, fQRS has consistently been shown to be a strong predictor of arrhythmic events in BrS (de Asmundis et al., 2017; Maury et al., 2013; Morita et al., 2008; Priori et al., 2012; Take et al., 2012; Tokioka et al., 2014).”
BackgroundResultSubcutaneous implantable cardioverter defibrillator in cardiomyopathies and channelopathies
Migliore, F., Pelliccia, F., Autore, C., Bertaglia, E., Cecchi, F., Curcio, A., Bontempi, L., Curnis, A., Filippo, P. D., D’Onofrio, A., et al. (2018) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000712 · Cited by 9
Chen, X., Zhao, H., Sun, L. V., Zhu, W., & Zhang, F. (2020) · Cardiology · doi:10.1159/000505642 · Cited by 9
Hohneck, A. L., Overhoff, D., Rutsch, M., Rudic, B., Tülümen, E., Wolpert, C., Hetjens, S., Akın, İ., Borggrefe, M. M., & Papavassiliu, T. (2021) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2021.05.003 · Cited by 9
Mascia, G., Brugada, J., Barca, L., Benenati, S., Bona, R. D., Scarà, A., Russo, V., Arbelo, E., Donna, P. D., & Porto, I. (2024) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001665 · Cited by 8
Contemporary Perspectives on J‐Wave Syndromes: An Expert Consensus Statement
Nademanee, K., Wilde, A. A. M., Ackerman, M. J., Behr, E. R., Bezzina, C. R., Chen, P., Chung, F., Coronel, R., Haı̈ssaguerre, M., Jiang, C., et al. (2026) · Journal of Arrhythmia · doi:10.1002/joa3.70284 · Cited by 8
“For symptomatic patients, the risk ranges from 3% to 15% [77, 78].”
InfluentialSelf-citationImplantable Cardioverter-Defibrillator for Primary Prevention in Asia
Younis, A., & Wilkoff, B. L. (2023) · JACC Asia · doi:10.1016/j.jacasi.2022.11.014 · Cited by 8
Scrocco, C., Ben‐Haim, Y., Ensam, B., Aldous, R. G., Tome, M., Specterman, M. J., Papadakis, M., Sharma, S., & Behr, E. R. (2024) · EP Europace · doi:10.1093/europace/euae091 · Cited by 8
“…4 Several clinical and ECG parameters have been proposed to identify subjects at risk of experiencing life-threatening arrhythmias during follow-up 5–7 ; a spT1 pattern at presentation has consistently been associated with increased risk, whereas a diT1 confers a better prognosis; however, the…”
BackgroundPredicting Sudden Cardiac Death in Genetic Heart Disease
Cadrin‐Tourigny, J., & Tadros, R. (2022) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2022.01.025 · Cited by 8
Risk stratification of sudden cardiac death in Brugada syndrome: an updated review of literature
Darar, C., El-Azrak, M., Boutaybi, M., Noha, E. O., & Bazid, Z. (2022) · The Egyptian Heart Journal · doi:10.1186/s43044-022-00267-9 · Cited by 10
“Then the prospective American PRELUDE registry, which involved 308 patients, 80% of whom were men and in whom a programed stimulation was performed with an average follow-up of 34 months, had shown that the inducibility of VT/VF did not make it possible to identify high-risk patients [5].”
BackgroundSp, G., Kostyukevich, M. V., Laiovich, L. I., Mironov, N. Y., Миронова, Н. А., Utsumueva, M. D., Khusyainova, D. R., Шлевков, Н. Б., Bazarov, B. C., Азизов, В. А., et al. (2022) · Eurasian heart journal · doi:10.38109/2225-1685-2022-4-6-67 · Cited by 10
García‐Izquierdo, E., Scrocco, C., Palacios-Rubio, J., Assaf, A., Ripoll‐Vera, T., Hernández-Betancor, I., Ramos-Ruiz, P., Melero-Pita, A., Segura-Domínguez, M., Jiménez‐Sánchez, D., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.03.003 · Cited by 8
Novel SCN5A p.W697X Nonsense Mutation Segregation in a Family with Brugada Syndrome
Micaglio, E., Monasky, M. M., Resta, N., Bagnulo, R., Ciconte, G., Giannelli, L., Locati, E. H., Vicedomini, G., Borrelli, V., Ghiroldi, A., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194920 · Cited by 8
“The presence of both syncope and a spontaneous type 1 ECG pattern has been described as a strong indicator of poor prognosis during follow-up (6% to 19% of patients will have an arrhythmic event within 24 to 39 months of follow-up) [9,30].”
BackgroundSelf-citationBrugada syndrome clinical update
Rojas, R., Kaul, R., Frenkel, D., Hoch, E. G., Iwai, S., Jacobson, J. T., & Aronow, W. S. (2021) · Hospital Practice · doi:10.1080/21548331.2021.1906012 · Cited by 8
Rodríguez‐Mañero, M., Baluja, A., Hernández, J., Muñoz‐Esparza, C., Calvo, D., Fernández‐Armenta, J., García-Fernández, A., Zorio, E., Arce‐León, Á., Sánchez‐Gómez, J. M., et al. (2021) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2021.07.007 · Cited by 8
Refaat, M., Hotait, M., & Scheinman, M. (2016) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2015.10.036 · Cited by 5
Overlapping Risks of Early Repolarization and Brugada Syndrome
Nademanee, K., & Veerakul, G. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.585 · Cited by 8
Arrhythmic Risk Stratification by Programmed Ventricular Stimulation in Brugada Syndrome
Belhassen, B., & Michowitz, Y. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003138 · Cited by 8
Metadata
- Authors
- Priori, S. G., Gasparini, M., Napolitano, C., Della Bella, P., Ottonelli, A. G., Sassone, B., Giordano, U., Pappone, C., Mascioli, G., Rossetti, G., De Nardis, R., & Colombo, M.
- Affiliations
- University of Pavia (IT)
- IRCCS Humanitas Research Hospital (IT)
- NYU Langone Health (US)
- Ospedale Versilia (IT)
- Azienda USL di Bologna (IT)
- Maria Cecilia Hospital (IT)
- Humanitas Gavazzeni (IT)
- Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT)
- Corresponding author
- Priori, Silvia G.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 59
- Issue
- 1
- Pages
- 37-45
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W140924846
- Cited by
- 581
- References
- 26
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 26 · 2023: 25 · 2022: 26 · 2021: 44 · 2020: 43 · 2019: 44 · 2018: 44 · 2017: 68 · 2016: 60 · 2015: 45 · 2014: 31 · 2013: 66 · 2012: 30
- FWCI
- 28.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Medtronic
- Boston Scientific Corporation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- Brugada syndrome, risk stratification, programmed electrical stimulation, implantable cardioverter-defibrillator, sudden cardiac death, syncope, ventricular effective refractory period, QRS fragmentation, arrhythmic events
- MeSH terms
- Adolescent, Adult, Aged, Cause of Death, Electric Stimulation, Electrocardiography, Female, Humans, Male, Middle Aged, Registries, Severity of Illness Index, Ventricular Fibrillation, Cohort Studies, Incidence, Survival Rate, Confidence Intervals, Defibrillators, Implantable, Tachycardia, Ventricular, Age Distribution, Sex Distribution, Risk Assessment, Patient Selection, Statistics, Nonparametric, Kaplan-Meier Estimate, Brugada Syndrome, Young Adult
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