Biomaterials for the Treatment of Myocardial Infarction
Open accessAbstract
The first review on biomaterials for the treatment of myocardial infarction (MI) was written in 2006. In the last 5 years, the general approaches for biomaterial treatment of MI and subsequent left ventricular remodeling remain the same, namely, left ventricular restraints, epicardial patches, and injectable therapies. Nonetheless, there have been significant developments in this field, including advancement of biomaterial therapies to large animal pre-clinical studies and, more recently, to clinical trials. This review focuses on the progress made in the field of cardiac biomaterial treatments for MI over the last 5 years.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Heart patch needs dynamic mechanical properties similar to elastic modulus and flexibility of myocardial tissue to withstand mechanical stress caused by heart beating.
“The heart patch needs to have dynamic mechanical properties, similar to the elastic modulus and flexibility of myocardial tissue, in order to withstand the mechanical stress caused by the beating of the heart.”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [163]
The Future Directions section says synthetic scaffold materials can be given elastic properties suitable for the heart’s dynamic environment and may reduce wall stress. It does not specify that a patch must match myocardial elastic modulus and flexibility, or establish that such matching is necessary to withstand the stress of each heartbeat. Page numbers are unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredHeart patch should have long-term mechanical stability and provide sufficient mechanical strength and integrity for extended period after implantation until formation of new tissue.
“Furthermore, the patch should have long-term mechanical stability and provide sufficient mechanical strength and integrity for an extended period after implantation, until the formation of new tissue [163].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [163]
The Future Directions section says a degradable scaffold provides temporary support until cells integrate into the host myocardium, supporting the idea of support during tissue development. It does not say a patch must retain long-term mechanical stability, strength, and integrity for an extended period; the same section discusses timely degradation instead. Page numbers were not available in our copy. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 89 · Cited by 226
- Authors
- Rane, A. A., & Christman, K. L.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Christman, Karen L.
- ORCID
- Christman, Karen L.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 58
- Issue
- 25
- Pages
- 2615-2629
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W177050335
- Cited by
- 226
- References
- 89
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 1 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 14 · 2019: 21 · 2018: 10 · 2017: 25 · 2016: 21 · 2015: 32 · 2014: 24 · 2013: 23 · 2012: 15
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Surgery › Cardiac Structural Anomalies and Repair
- Keywords
- myocardial infarction, left ventricular remodeling, epicardial patch, injectable therapy, clinical trials
- MeSH terms
- Biocompatible Materials, Humans, Myocardial Infarction, Treatment Outcome, Ventricular Remodeling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
