The DOI matches its Crossref record; 227 of the 227 references it cites were found in a registry or an index.
Endothelial Dysfunction, Arterial Stiffness, and Heart Failure
Open accessAbstract
Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results have been negative or neutral. Improvement in surrogate markers has not necessarily translated into better outcomes. To translate breakthroughs with potential therapies into clinical benefit, a better understanding of the pathophysiology establishing the foundation of benefit is necessary. Vascular function plays a central role in the development and progression of HF. Endothelial function and nitric oxide availability affect myocardial function, systemic and pulmonary hemodynamics, and coronary and renal circulation. Arterial stiffness modulates ventricular loading conditions and diastolic function, key components of HF with preserved ejection. Endothelial function and arterial stiffness may therefore serve as important physiological targets for new HF therapies and facilitate patient selection for improved application of existing agents.
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Vascular Endothelial Cell Biology: An Update
Krüger-Genge, A., Blocki, A., Franke, R.-P., & Jung, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184411 · Cited by 1,163
Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus: Results From the CANVAS Program
Rådholm, K., Figtree, G., Perkovic, V., Solomon, S. D., Mahaffey, K. W., de Zeeuw, D., Fulcher, G., Barrett, T. D., Shaw, W., Desai, M., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.034222 · Cited by 488
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Leveraging Physiology for Precision Drug Delivery
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Metadata
- Authors
- Marti, C. N., Gheorghiade, M., Kalogeropoulos, A. P., Georgiopoulou, V. V., Quyyumi, A. A., & Butler, J.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 60
- Issue
- 16
- Pages
- 1455-1469
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2049978396
- Cited by
- 488
- References
- 227
- FWCI
- 18.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Marti, C. N., Gheorghiade, M., Kalogeropoulos, A. P., Georgiopoulou, V. V., Quyyumi, A. A., & Butler, J. (2012). Endothelial Dysfunction, Arterial Stiffness, and Heart Failure. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2011.11.082
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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